149 Results for "

protease substrates

" in MedChemExpress (MCE) Product Catalog:
Products (149)

149 Results for "protease substrates" in MCE Product Catalog:

Cat. No.: HY-P2630
CAS No.: 208264-84-0
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Suc-YVAD-pNA is a substrate of ICE. Interleukin-1β-converting enzyme (ICE) is a cysteine protease responsible for the cleavage of pre-interleukin-1β (pre-IL-1β) to the mature cytokine and a member of a family of related proteases (the caspases) .
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Cat. No.: HY-171045
CAS No.: 249618-84-6
Research Areas:  

Others

Abz-FRF(4NO2) is an Abz-tripeptide substrate commonly used for studying the activity of enzymes, especially cysteine proteases such as Cathepsin X .
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Cat. No.: HY-P5415
CAS No.: 127134-13-8
Target:  

HIV

Research Areas:  

Others

DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is a biological active peptide. (DABCYL-GABA-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-EDANS is also called HIV protease substrate I in some literature. It is widely used for the continuous assay for HIV protease activity. The 11-Kd protease (PR) encoded by the human immunodeficiency virus 1 (HIV-1) is essential for the correct processing of viral polyproteins and the maturation of infectious virus, and is therefore a target for the design of selective acquired immunodeficiency syndrome (AIDS) therapeutics. The FRET-based fluorogenic substrate is derived from a natural processing site for HIV-1 PR. Incubation of recombinant HIV-1 PR with the fluorogenic substrate resulted in specific cleavage at the Tyr-Pro bond and a time-dependent increase in fluorescence intensity that is linearly related to the extent of substrate hydrolysis. The fluorescence quantum yields of the HIV-1 PR substrate in the FRET assay increased by 40.0- and 34.4-fold, respectively, per mole of substrate cleaved. Because of its simplicity and precision in the determination of reaction rates required for kinetic analysis, this substrate offers many advantages over the commonly used HPLC or electrophoresis-based assays for peptide substrate hydrolysis by retroviral PRs. Abs/Em = 340nm/490nm.)
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Cat. No.: HY-P4466
CAS No.: 130877-92-8
Target:  

HIV Protease

Research Areas:  

Infection

Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 is a fluorogenic substrate of HIV-1 protease. Arg-Val-(Nle-p-nitro)-Phe-Glu-Ala-Nle-NH2 can be used to test HIV-1 protease activity .
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Cat. No.: HY-E70568
Target:  

Ser/Thr Protease

Research Areas:  

Others

Protease (O-glycan Cleaving) is recombinantly expressed from E.coli and contains a His tag. Protease (O-glycan Cleaving) is an O-glycan-dependent protease that digests proteins carrying mucin-type O-glycans, including sialylated substrates, glycosylated Ser and Thr residues at the N terminus. Protease (O-glycan Cleaving) digests a variety of O-glycan structures, including sialylated glycosylated core 1 and core 2 structures and Tn antigen. Protease (O-glycan Cleaving) does not digest terminally modified serine or threonine residues, nor does it digest N-glycosylation sites on glycoproteins.
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Cat. No.: HY-P5312A
Target:  

Virus Protease

Research Areas:  

Infection

Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate is the acetate salt form of Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr. Abz-Gly-Leu-Lys-Arg-Gly-Gly-3-(NO2)Tyr acetate is the substrate for WNV NS2B NS3 protease, which is utilized for the development of WNV protease substrate peptide selective inhibitor .
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Cat. No.: HY-P2296
Target:  

Fluorescent Dye

Research Areas:  

Others

Abz-FRLKGGAPIKGV-EDDNP TFA is a fluorogenic substrate used to measure the enzymatic activities of protease forms, such as papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV). Abz-FRLKGGAPIKGV-EDDNP TFA has the potential for study 2019-nCoV (COVID-19) infection .
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Cat. No.: HY-P2628
CAS No.: 161877-70-9
Target:  

Fluorescent Dye

Research Areas:  

Others

Dabcyl-YVADAPV-EDANS is a fluorogenic interleukin-1β converting enzyme (ICE) substrate for measuring ICE-like protease activity. Dabcyl-YVADAPV-EDANS detects fluorescence at 360 nm excitation and 480 nm emission wavelengths. ICE-like protease is a critical mediator of K + deprivation-induced apoptosis of cerebellar granule neurons .
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Cat. No.: HY-150242A
Purity:  99.54%
Target:  

Liposome

Research Areas:  

Others

Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery .
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Cat. No.: HY-P5313
Target:  

Dengue Virus

Research Areas:  

Infection

Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr is a DEN protease substrate, which can be used in research related to dengue virus (drug development) .
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Cat. No.: HY-P4038
CAS No.: 191529-67-6
Target:  

HCV Protease

Research Areas:  

Infection

Hepatitis C Virus S5A/5B is a synthetic peptide substrate. Hepatitis C Virus S5A/5B mimics the NS5A/5B junction of the nonstructural protein (NS), served as the substrate for the study of HCV NS3 protease activity .
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Cat. No.: HY-168378
CAS No.: 63589-93-5
Synonyms: S-2251
Target:  

Fluorescent Dye

Research Areas:  

Others

D-Val-Leu-Lys-pNA (S-2251) is a chromogenic peptide substrate that serves as a characteristic substrate for plasmin and plasminogen. D-Val-Leu-Lys-pNA acts as a sensitive substrate for the DFE27 serine protease derived from Bacillus subtilis DC27. Catalyzed by plasmin, D-Val-Leu-Lys-pNA binds and hydrolyzes to release p-nitroaniline (pNA), which can be detected colorimetrically at 405 nm as a measure of fibrinolytic activity .
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Cat. No.: HY-P4465
CAS No.: 103192-40-1
Target:  

Fluorescent Dye

Research Areas:  

Others

Gly-Arg-pNA is a fluorogenic substrate for the measurement of protease activity. Gly-Arg-pNA undergoes hydrolysis and releases the fluorescent product p-nitroaniline. p-nitroaniline is in a fluorescent state under ultraviolet light irradiation and can emit a fluorescent signal .
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Cat. No.: HY-17367S3
CAS No.: 1132747-14-8
Atazanavir-d5 is the deuterium labeled Atazanavir. Atazanavir (BMS-232632), a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir (BMS-232632) is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM .
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Cat. No.: HY-17367AR
CAS No.: 229975-97-7
Synonyms: BMS-232632 sulfate (Standard)
Atazanavir (sulfate) (Standard) is the analytical standard of Atazanavir (sulfate). This product is intended for research and analytical applications. Atazanavir (BMS-232632) sulfate, a highly selective HIV-1 protease inhibitor, is the first protease inhibitor approved for once-daily administration . Atazanavir sulfate is a substrate and inhibitor of CYP3A4, and an inhibitor and inducer of P-glycoprotein (P-gp) . Atazanavir sulfate is also a SARS-CoV 3CLpro inhibitor with an IC50 of 3.49 μM .
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Cat. No.: HY-E70326
Target:  

Endogenous Metabolite

Research Areas:  

Others

Acid Protease, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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Cat. No.: HY-P4419
CAS No.: 113866-00-5
Target:  

Fluorescent Dye

Research Areas:  

Others

Boc-Asp(OBzl)-Pro-Arg-AMC is a fluorogenic substrate for the determination of protease activity. Boc-Asp(OBzl)-Pro-Arg-AMC undergoes hydrolysis and releases the fluorescent product 7-amino-4-methylcoumarin (AMC). The excitation and emission wavelengths are 351 nm and 430 nm, respectively .
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Cat. No.: HY-P11420A
Target:  

Dengue Virus

Research Areas:  

Infection

2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) acetate is a peptide substrate for the Dengue NS2B-NS3 protease, with a Ki value of 12 μM. 2A/2B Dengue protease substrate acetate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease .
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Cat. No.: HY-P11420
CAS No.: 410532-55-7
Target:  

Dengue Virus

Research Areas:  

Infection

2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a peptide substrate for the Dengue NS2B-NS3 protease, with a Ki value of 12 μM. 2A/2B Dengue protease substrate is used in the development of selective peptide-based inhibitors for the Dengue NS2B-NS3 protease .
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Cat. No.: HY-P11734
CAS No.: 72682-75-8
Target:  

Ser/Thr Protease

Research Areas:  

Others

Suc-AAPY-pNA is an oligptide compound and protease substrate. Suc-AAPY-pNA undergoes hydrolysis by proteases at the peptide bond between tyrosine and p-nitroaniline, releasing p-nitroaniline with an absorption peak at OD410. Suc-AAPY-pNA functions as a substrate in preclinical assays for measuring activity of acidic, neutral, and alkaline proteases .
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