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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
249 Results for "
shape-selective methylation
" in MedChemExpress (MCE) Product Catalog:
Products (249)
249 Results for "shape-selective methylation" in MCE Product Catalog:
Cat. No.: HY-W013500
CAS No.: 1215-07-2
Synonyms: alpha-Nitrostilbene; α-Nitrostilbene; NSC 385
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(1-Nitroethene-1,2-diyl)dibenzene (alpha-Nitrostilbene; α-Nitrostilbene) is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50=11 μM in histone H4 methylation assay). It also inhibits histone H4 methylation by PRMT8, but not histone H3.1 methylation by CARM1 or Set7/9, at concentrations of 10 and 100 μM.
Cat. No.: HY-W338810
CAS No.: 24346-00-7
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Cat. No.: HY-W338810S
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S-(5'-Adenosyl)-L-methionine- 13C5 sulfate is the 13C-labeled S-(5'-Adenosyl)-L-methionine chloride (HY-W338810). S-(5'-Adenosyl)-L-methionine chloride is the endogenous methyl donor in the methionine cycle and numerous methylation reactions, including protein methylation. S-(5'-Adenosyl)-L-methionine chloride can activate cardiac ryanodine receptor RyR2 in a concentration-dependent manner, enhancing the affinity of RyR2 for ryanodine. The Kd of S-(5'-Adenosyl)-L-methionine chloride with MetJ in Escherichia coli is 0.18 mM. S-(5'-Adenosyl)-L-methionine chloride can cause changes in the methylation index of Cisplatin (HY-17394)-sensitive and Cisplatin-resistant ovarian cancer cells. S-(5'-Adenosyl)-L-methionine chloride can be used for methylation-related research .
Cat. No.: HY-104009
CAS No.: 2245255-65-4
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GSK2807 is a potent and selective SAM-competitive inhibitor of SMYD3, exhibiting a Ki value of 14 nM, and it may be useful for cancer treatment by preventing the methylation of MEKK2.
Tetrachloroveratrole is one of the biodegradation products of bacterial O-methylation of Tri- and Tetra chloroguaiacols. The Tri- and Tetra chloroguaiacols are formed during bleaching of wood pulp in the paper manufacturing industry .
Cat. No.: HY-147101
CAS No.: 2523017-04-9
SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM .
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Bizine dihydrochloride, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine dihydrochloride can modulate bulk histone methylation in cancer cells. Bizine dihydrochloride shows neuroprotective effects .
Cat. No.: HY-106689A
CAS No.: 2470972-18-8
Synonyms: DHAC acetate; NSC 264880 acetate
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Dihydro-5-azacytidine acetate (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine acetate has an antitumor activity .
Cat. No.: HY-N14823
CAS No.: 79404-98-1
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Cat. No.: HY-P2556
CAS No.: 1373516-71-2
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Cat. No.: HY-W242821
CAS No.: 5396-64-5
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Simple Phenylpropanols Amburana cearensis (Allemão) A.C.Sm. Leguminosae Extract Phenylpropanoids Plants
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Cat. No.: HY-P4756
CAS No.: 282725-67-1
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Cat. No.: HY-112080A
CAS No.: 2283389-29-5
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(R)-BAY-6035 is a novel inhibitor that selectively targets the methylation of MAP3K2 by SMYD3, demonstrating nanomolar potency and specificity against kinases and other protein lysine methyltransferases.
Cat. No.: HY-16513R
CAS No.: 23261-20-3
Synonyms: Dianhydrodulcitol (Standard); Dianhydrogalactitol (Standard)
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VAL-083 (Standard) is the analytical standard of VAL-083. This product is intended for research and analytical applications. VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.
Cat. No.: HY-P2555
CAS No.: 2130981-29-0
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Cat. No.: HY-118836
CAS No.: 607742-80-3
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GSK215083 is a high affinity 5-HT6 receptor antagonist. GSK215083 can serves as a promising 5-HT6 radioligand candidate by radiolabeled with (11)C via methylation .
Cat. No.: HY-W063263
CAS No.: 4030-18-6
Synonyms: N-Acetylpyrrolidine
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1-Acetylpyrrolidine (N-acetylpyrrolidine) is a smoking-related metabolite. 1-Acetylpyrrolidine can induce low methylation at DNA CpG site. 1-Acetylpyrrolidine can be used for the research on the mechanisms of smoking-related diseases and the development of biomarkers .
Cat. No.: HY-168143
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YD1342 is a prodrug of YD1130, which exhibits potent inhibitory effects on cellular substrate methylation, breast cancer cell clonogenicity, and tumor growth in animal models, exceeding or matching known PRMT4-specific inhibitors. .
Cat. No.: HY-10587A
CAS No.: 1808255-64-2
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BIX-01294 hydrochloride hydrate is a histone-lysine methyltransferase (HMTase) inhibitor, which selective inhibits the G9aHMTase with IC50 of 1.7 μM, reduces histone-3 lysine (9) methylation (H3K9me), induces autophagy and apoptosis in human glioma cells .
Cat. No.: HY-P10028
CAS No.: 2388988-70-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
