Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
249 Results for "
shape-selective methylation
" in MedChemExpress (MCE) Product Catalog:
Products (249)
249 Results for "shape-selective methylation" in MCE Product Catalog:
Cat. No.: HY-113081R
CAS No.: 15763-06-1
Cat. No.: HY-121095
CAS No.: 1591932-50-1
Target:
Research Areas:
Bizine, a Phenelzine analogue, is a potent and selective LSD1 inhibitor, with a b>Ki of 59 nM. Bizine can modulate bulk histone methylation in cancer cells. Bizine shows neuroprotective effects .
Target:
Research Areas:
CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32 nM. CP 226269 stimulates phospholipid methylation (PLM) in SK-N-MC neuroblastoma cells with an EC50 of 2.9 nM. CP 226269 can be used in the research of schizophrenia and other related diseases .
Target:
Research Areas:
Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .
Cat. No.: HY-106689
CAS No.: 62488-57-7
Synonyms: DHAC; NSC 264880
Research Areas:
Dihydro-5-azacytidine (DHAC), the nucleoside analog, is incorporated into DNA and inhibits DNA methylation. Dihydro-5-azacytidine has an antitumor activity .
Cat. No.: HY-W850994
CAS No.: 93911-12-7
Synonyms: Tridecyl beta-D-maltopyranoside
Cat. No.: HY-103641C
CAS No.: 2097068-39-6
Synonyms: Octyl-2-HG
Target:
Research Areas:
Octyl-α-hydroxyglutarate (octyl-2-HG) increases histone methylation and enhances viability of LMP1-negative NPC cells .
Cat. No.: HY-145654
CAS No.: 1962174-21-5
Target:
Research Areas:
MRS-4203 is an ADK (IC50 = 88 nM) inhibitor. MRS-4203 can reduce DNA methylation. MRS-4203 is commonly used in cancer research .
Target:
Research Areas:
Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .
Cat. No.: HY-P10828
CAS No.: 1260620-30-1
Target:
Research Areas:
Cat. No.: HY-154839
CAS No.: 2299227-75-9
c-Myc inhibitor 10 (compound 17), a c-Myc inhibitor, exhibits increased cellular potency, consistent with an increase in permeability with methylation of the morpholine nitrogen .
Cat. No.: HY-126733
CAS No.: 73951-54-9
Synonyms: (6R)-Folinic acid
Target:
Research Areas:
(6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate .
Cat. No.: HY-133604
CAS No.: 16766-29-3
Target:
Research Areas:
3,4,5-Trichloroveratrole is one of the biodegradation products of bacterial O-methylation of Tri- and Tetra chloroguaiacols. The Tri- and Tetra chloroguaiacols are formed during bleaching of wood pulp in the paper manufacturing industry .
Cat. No.: HY-111589
CAS No.: 1381761-52-9
Target:
Research Areas:
EPZ-4777 is a selective DOT1L inhibitor which inhibits H3K79 methylation in cancer cells, blocks the expression of leukemogenic genes, and selectively kills cells that contain the translocation. EPZ-4777 can be used for cancer research .
Cat. No.: HY-113352S
CAS No.: 17829-03-7
Synonyms: Glycerol triheptadecanoate; Trimargarin
Target:
Research Areas:
Triheptadecanoin (Glycerol triheptadecanoate) is an internal standard for the rapid GC analysis of fatty acid methyl esters in edible fats and oils. Triheptadecanoin enables the quantitative analysis of trans-fatty acid content in edible fats and oils via a rapid GC method. Triheptadecanoin smoothly undergoes methylation with m-TFPTAH in toluene solution at room temperature .
Cat. No.: HY-L203
351 compounds
Methylation is an epigenetic modification mechanism that involves adding methyl groups to molecules such as DNA and histones, which can alter gene expression without changing the DNA sequence. This process is catalyzed by enzymes such as DNA methyltransferases (DNMTs) and histone methyltransferases (HMTs), and can be reversed by demethylases. The balance of methylation and demethylation is crucial for maintaining cellular function and genomic stability. Abnormal regulation of methylation may lead to a variety of diseases, including cancer, neurological disorders, and developmental abnormalities. A deep understanding of the molecular mechanisms of methylation metabolism is essential for developing therapeutic strategies for diseases associated with methylation dysregulation.
MCE contains 351 compounds targeting methylation/demethylation enzymes, which is of significant value for studying the pathways of methylation metabolism and exploring their mechanisms of action in diseases.
Cat. No.: HY-149730
CAS No.: 908856-14-4
ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
