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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5704 Results for "
solid-state NMR analysis
" in MedChemExpress (MCE) Product Catalog:
Products (5704)
5704 Results for "solid-state NMR analysis" in MCE Product Catalog:
Art. -Nr.: HY-N7480A
CAS. Nr.: 815576-68-2
Category:
Alkaloids Microorganisms Pyrrole Alkaloids Neurological Disease Quinoline Alkaloids Disease Research Fields
Target:
Art. -Nr.: HY-111333
CAS. Nr.: 105888-54-8
Synonyms: Dioxapyrrolomycin; LL-F42248α; AL-R2081
Category:
Target:
Art. -Nr.: HY-116013S1
CAS. Nr.: 861924-55-2
Art. -Nr.: HY-120410
CAS. Nr.: 1674389-55-9
Target:
Forschungsgebiete:
DL-4662 is a 3,4-dimethoxy derivative that can be identified using techniques such as, GC-EI-MS, LC-tandem mass spectrometry and NMR spectroscopy .
Art. -Nr.: HY-167680
CAS. Nr.: 483369-58-0
Synonyms: GSK823093
Target:
Forschungsgebiete:
Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings .
Art. -Nr.: HY-W209558
CAS. Nr.: 2020-90-8
Synonyms: 2,4,5-Trimethoxyphenylacetone
Target:
Art. -Nr.: HY-34849
CAS. Nr.: 53531-34-3
Target:
Forschungsgebiete:
(R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol is utilized as a chiral shift reagent for determining enantiomeric ratios. Additionally, (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol can be employed for nuclear magnetic resonance (NMR) optical purity determination .
Art. -Nr.: HY-119387
CAS. Nr.: 1318025-75-0
Category:
Target:
Art. -Nr.: HY-147186
CAS. Nr.: 156027-00-8
Target:
Forschungsgebiete:
5,5'-Difluoro BAPTA is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA is the most widely used probe for studying cytosolic free Ca 2+ by 19F NMR. 5,5'-Difluoro BAPTA has high selectivity for Ca 2+. 5,5'-Difluoro BAPTA can inhibit the growth of pollen tube .
Art. -Nr.: HY-118205
CAS. Nr.: 637772-75-9
SCH-538415 is a novel acyl carrier protein synthase inhibitor isolated from an unknown bacterial microorganism. The structural elucidation of compound 1 was completed by analyzing spectral data including UV, MS and 2D-NMR spectra. Compound 1 showed inhibitory activity in the acyl carrier protein synthase (AcpS) test with an IC50 value of 4.19 μM and exhibited antibacterial activity against Staphylococcus aureus in the agar diffusion test.
Art. -Nr.: HY-122038
CAS. Nr.: 849723-20-2
NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines .
Art. -Nr.: HY-145922
Target:
Forschungsgebiete:
ChemR23 ligand-1 is a chemical probe that contributes to the elucidation and analysis of the functions of ChemR23.
Art. -Nr.: HY-145407A
ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .
Art. -Nr.: HY-W354693
CAS. Nr.: 615-05-4
Target:
Forschungsgebiete:
2,4-Diaminoanisole is a carcinogenic aromatic primary amine compound that can be used in the analysis of reference standards .
Art. -Nr.: HY-145407
CAS. Nr.: 2698333-36-5
16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C .
Art. -Nr.: HY-W127464
CAS. Nr.: 36617-18-2
Art. -Nr.: HY-113278R
CAS. Nr.: 3063-05-6
Art. -Nr.: HY-I1198
CAS. Nr.: 2169998-23-4
Synonyms: Oxo-dapagliflozin
Target:
Forschungsgebiete:
Dapagliflozin keto impurity (Oxo-dapagliflozin) is an oxo metabolite and related impurity of Dapagliflozin (HY-10450). Dapagliflozin keto impurity can be characterized by 1H NMR, 13C NMR and HRMS, and can be used in studies related to Dapagliflozin impurities and metabolites .
Art. -Nr.: HY-165134
CAS. Nr.: 223130-52-7
Category:
Target:
Art. -Nr.: HY-L152
5,077 compounds
19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD.
MCE designs a unique collection of 5,077 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
