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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
224 Results for "
cholinergic eeceptor
" in MedChemExpress (MCE) Product Catalog:
Products (224)
224 Results for "cholinergic eeceptor" in MCE Product Catalog:
Cat. No.: HY-12641R
CAS No.: 33401-94-4
Target:
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Pyrantel tartrate (Standard) is the analytical standard of Pyrantel tartrate (HY-12641). This product is intended for research and analytical applications. Pyrantel tartrate is an orally active antiparasitic agent. Pyrantel tartrate induces spastic paralysis in parasites via actions on neural and muscular cholinergic receptors as a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel tartrate eliminates both immature and mature endoparasites in horses. Pyrantel tartrate can be used in research related to parasitic infections .
Cat. No.: HY-136625
CAS No.: 71274-97-0
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LY134046 is an inhibitor of norepinephrine N-methyltransferase (NMT) with cardiovascular activity. LY134046 causes sustained reductions in mean arterial blood pressure and heart rate, but no significant reductions in norepinephrine concentrations in the rat brain. LY134046 does not interact with adrenergic or cholinergic receptors, and its hypotensive and bradycardic effects do not require neurogenic tension. LY134046 (40 mg/kg/day) causes sustained and significant inhibition of hypothalamic and brainstem NMT activity, resulting in central norepinephrine depletion.
Cat. No.: HY-148605
CAS No.: 119610-26-3
Target:
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Aloracetam is a γ-aminobutyric acid cyclic derivative that can pass through the blood-brain barrier and has a significant enhancing cognitive function effect. Aloracetam improves the blood perfusion of brain tissue, increases the synthesis of proteins, ATP and acetylcholine in the brain, enhances the excitatory conduction effect of cholinergic nerves, and reduces the damage to brain tissue caused by cerebral vascular diseases. Aloracetam also has certain anti-epileptic, anti-inflammatory, analgesic and anti-depressant effects .
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Trimedoxime dichloride (TMB-4 dichloride) is a blood-brain barrier-permeable cholinesterase reactivator . Trimedoxime dichloride reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime dichloride reduces mortality and prolongs survival time. Trimedoxime dichloride exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime dichloride can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning .
Cat. No.: HY-17368S1
CAS No.: 194930-04-6
Synonyms: (Rac)-ENA 713-d6 free base; (Rac)-SDZ-ENA 713-d6 free base
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Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .
Cat. No.: HY-B1339AS
CAS No.: 2803506-01-4
Synonyms: Dicycloverine-d4
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Research Areas:
Dicyclomine (hydrochloride) (Standard) is the analytical standard of Dicyclomine (hydrochloride). This product is intended for research and analytical applications. Dicyclomine hydrochloride is a potent and orally active muscarinic cholinergic receptors antagonist. Dicyclomine hydrochloride shows high affinity for muscarinic M1 receptor subtype (Ki=5.1 nM) and M2 receptor subtype (Ki=54.6 nM) in brush-border membrane and basal plasma membranes, respectively . Dicyclomine is an antispasmodic agent and relieves smooth muscle spasm of the gastrointestinal tract in vivo .
Cat. No.: HY-P1831
CAS No.: 150238-87-2
Synonyms: ProAM N20, Human; PAMP-20, human
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Cat. No.: HY-W654336
Cat. No.: HY-P703104
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: CHRM2; M2 Muscarinic Acetylcholine Receptor; cholinergic Receptor Muscarinic 2; Muscarinic Acetylcholine Receptor; Acetylcholine Receptor, Muscarinic 2; 7TM Receptor; Muscarinic Acetylcholine Receptor M2; HM2; Muscarinic M2 Receptor
Species:
Human
Source:
HEK293
Cat. No.: HY-118056
CAS No.: 1047670-51-8
Target:
ABD459 is a CB1 receptor antagonist with significant effects on regulating food intake and sleep-wake cycles. ABD459 completely displaces CB1 agonist CP99540 (Ki = 8.6 nM) and antagonizes CP55940-induced GTPγS binding (KB = 7.7 nM). ABD459 may specifically modulate endogenous cannabinoid release through cholinergic activity and plays a role in attention and arousal regulation. ABD459 is suitable for research in neurological disorders .
Cat. No.: HY-118646
CAS No.: 753500-02-6
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NS-6740 is a silent agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 reduces LPS-induced TNF-α release and regulates the cholinergic anti-inflammatory pathway. NS-6740 exerts anti-inflammatory effects. NS-6740 reduces long-term potentiation in hippocampal brain slices. NS-6740 can be used in research related to neuroinflammation and schizophrenia .
Cat. No.: HY-118646A
CAS No.: 753499-14-8
Target:
NS-6740 hydrochloride is a silent agonist of α7 nicotinic acetylcholine receptor (α7 nAChR) with an IC50 of 3 nM. NS-6740 hydrochloride reduces LPS-induced TNF-α release and regulates the cholinergic anti-inflammatory pathway. NS-6740 hydrochloride exerts anti-inflammatory effects. NS-6740 hydrochloride reduces long-term potentiation in hippocampal brain slices. NS-6740 hydrochloride can be used in research related to neuroinflammation and schizophrenia .
Cat. No.: HY-124920S
CAS No.: 1581694-94-1
Synonyms: Mercaptodimethur-d3
Cat. No.: HY-12640R
CAS No.: 22204-24-6
Synonyms: Pyrantel embonate (Standard)
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Research Areas:
Pyrantel pamoate (Standard) (Pyrantel embonate (Standard)) is the analytical standard of Pyrantel pamoate (HY-12640). This product is intended for research and analytical applications. Pyrantel pamoate is an orally active antiparasitic agent. Pyrantel pamoate induces spastic paralysis in parasites via actions on neural and muscular cholinergic receptors as a nicotinic acetylcholine receptor (nAChR) agonist. Pyrantel pamoate eliminates both immature and mature endoparasites in horses. Pyrantel pamoate can be used in research related to parasitic infections .
Cat. No.: HY-173396
CAS No.: 1432438-14-6
Synonyms: VU319
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Research Areas:
VU0467319 (Compound VU319) is a highly selective and blood-brain-permeable, orally active M1 positive allosteric modulator (PAM) (EC50: 492 nM). VU0467319 is selective (EC50 > 30 μM) versus M2-5 for both human and rat. VU0467319 improves cognitive impairment in Alzheimer's disease (AD) through central M1 muscarinic receptors. VU0467319 does not induce cholinergic adverse reactions and has potential in AD research .
Cat. No.: HY-17368R
CAS No.: 123441-03-2
Synonyms: ENA 713 free base(Standard); SDZ-ENA 713 free base(Standard)
Research Areas:
Rivastigmine (Standard) is the analytical standard of Rivastigmine. This product is intended for research and analytical applications. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .
Cat. No.: HY-17368S2
Synonyms: ENA 713-d3 hydrochloride; SDZ-ENA 713-d3 hydrochloride
Cat. No.: HY-B1339S
Synonyms: Dicycloverine-d4 hydrochloride
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
