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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
ATRA
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "ATRA" in MCE Product Catalog:
150
150 Cited Publications
Synonyms: Vitamin A acid; all-trans-Retinoic acid; ATRA
Synonyms: Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)
Cat. No.: HY-NP004
Synonyms: CVF
Synonyms: Biotin-ATRA-conjugate
Target:
Cat. No.: HY-14649S4
CAS No.: 78996-15-3
Synonyms: Vitamin A acid-d5; all-trans-Retinoic acid-d5; ATRA-d5
Target:
Research Areas:
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .
Cat. No.: HY-108531A
Purity: 99.86%
ER 50891 quarterhydrate is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis .
Cat. No.: HY-118761
CAS No.: 13100-69-1
Synonyms: 5,6-epoxy ATRA; 5,6-epoxy RA
Target:
Research Areas:
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC50s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.
Cat. No.: HY-169863
CAS No.: 2324152-25-0
Target:
Research Areas:
DC360 is a synthetic retinoid analogue of all-trans retinoic acid (ATRA) which induces RARβ expression. DC360 can be utilized in characterization of retinoid signalling pathways .
Synonyms: Vitamin A acid-d6; all-trans-Retinoic acid-d6; ATRA-d6
Cat. No.: HY-111839
CAS No.: 135325-47-2
Synonyms: CRABP-II ligand 1
Research Areas:
ATRA-hydroxyimino (CRABP-II ligand 1), the Retinoic acid (ATRA)-based moiety, binds to cIAP1 ligand (Bestatin) via a linker to form SNIPER to degrade CRABP-II in IMR-32 cells .
Cat. No.: HY-14649S5
CAS No.: 154461-49-1
Synonyms: Vitamin A acid-d3; all-trans-Retinoic acid-d3; ATRA-d3
Cat. No.: HY-14649S6
CAS No.: 3041101-53-2
Synonyms: Vitamin A acid-d3-1; all-trans-Retinoic acid-d3-1; ATRA-d3-1
Cat. No.: HY-123647
CAS No.: 53126-64-0
Category:
Cat. No.: HY-182728
CAS No.: 110952-26-6
Target:
Research Areas:
CD564 (Compound 11b) is a cytochrome P450 CYP26A1 and CYP26B1 inhibitor, with IC50 values of 1.63 μM and 0.52 μM, respectively. Cytochrome P450 CYP26 enzymes clear all-trans retinoic acid (atRA) .
Cat. No.: HY-184097
CAS No.: 3098670-37-9
MS9117 is a PROTAC molecule that targets and degrades LSD1/BHC110 by recruiting CRBN. MS9117 effectively increases the level of histone H3 lysine 4 monomethylation. MS9117 significantly inhibits the proliferation and colony formation of cancer cells, promotes their myeloid differentiation, and enhances the sensitivity of non-acute promyelocytic leukemia-type AML cells to all-trans retinoic acid (ATRA) .
Cat. No.: HY-182948
CAS No.: 2089135-65-7
Target:
Research Areas:
Dichloro-all-trans-retinone is a selective retinaldehyde dehydrogenase (RALDH) inhibitor, with an IC50 of 434.7 nM and a Ki of 194.4 nM against chicken RALDH1; an IC50 of 55 nM and a Ki of 5.1 nM against chicken RALDH2; an IC50 of 191.32 nM and a Ki of 64.35 nM against human RALDH2; and an IC50 of 161.27 nM and a Ki of 6.74 nM against chicken RALDH3. Dichloro-all-trans-retinone inhibits the synthesis of all-trans retinoic acid (ATRA). Dichloro-all-trans-retinone is applicable to research related to form-deprivation-induced myopia .
Cat. No.: HY-138032
CAS No.: 326914-17-4
Synonyms: N,N-Dimethyl sunitinib
Research Areas:
SU11657 (N,N-Dimethyl sunitinib) is an orally active multi-targeted tyrosine kinase inhibitor with IC50 values of 0.04 μM (c-Kit), 0.005 μM (PDGFR), 0.013 μM (VEGFR1), 0.017 μM (VEGFR2) and 50 nM (FLT3), respectively. SU11657 exhibits anti-angiogenic activity. SU11657 delays leukemia progression, synergizes with ATRA (HY-14649) to reduce leukemia burden, and inhibits symptoms and tissue damage associated with rheumatoid arthritis. SU11657 can be used in research related to FLT3-mutated acute promyelocytic leukemia, rheumatoid arthritis, neuroblastoma, and benign/atypical meningioma .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
