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Results for "

5‐HT1C

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (29) Bacterial (5) Calcium Channel (1) Dopamine Receptor (4) Isotope-Labeled Compounds (2) Phytohormone (1) Potassium Channel (2) Reference Standards (6) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cardiovascular Disease (1) Inflammation/Immunology (2) Neurological Disease (27)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19545A

SCH-23390 hydrochloride Maximum Cited Publications 31 Publications Verification R-(+)-SCH-23390 hydrochloride	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM .

HY-14940

Volinanserin 5+ Cited Publications MDL100907; M 100907	5-HT Receptor	Neurological Disease
Volinanserin is a potent and selective antagonist of 5-HT₂ receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT₂ receptor over 5-HT_1c, alpha-1 and DA D₂ receptors. Volinanserin has antipsychotic activity.

HY-B1213

Trimipramine maleate 1 Publications Verification	5-HT Receptor Bacterial	Neurological Disease
Trimipramine maleate is a 5-HT receptor antagonist, with blood-brain barrier permeability. Trimipramine maleate has pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-107836

Methiothepin mesylate 2 Publications Verification Metitepine mesylate; Ro 8-6837 mesylate	5-HT Receptor	Neurological Disease
Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-B0115

Pizotifen 2 Publications Verification Pizotyline; BC-105	5-HT Receptor	Neurological Disease
Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B0115A

Pizotifen malate 2 Publications Verification Pizotyline malate; BC-105 malate	5-HT Receptor	Neurological Disease
Pizotifen malate (Pizotyline malate) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-101324A

MK-212 monohydrochloride CPP monohydrochloride	5-HT Receptor	Neurological Disease
MK-212 (CPP) monohydrochloride is a centrally acting *5-HT_1C/5-HT₂* agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex .

HY-14940S

Volinanserin-d4 hydrochloride MDL100907-d4 hydrochloride; M 100907-d4 hydrochloride	5-HT Receptor	Neurological Disease
Volinanserin-d₄ (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity .

HY-14940A

(S)-Volinanserin (S)-MDL100907; (S)-M 100907	5-HT Receptor	Neurological Disease
(S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT₂ receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT₂ receptor over 5-HT_1c, alpha-1 and DA D₂ receptors. Volinanserin has antipsychotic activity.

HY-100971

Spiramide AMI-193	5-HT Receptor Dopamine Receptor	Neurological Disease
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus *5-HT_1C* (K_i=4300 nM) receptors. Spiramide exhibits antipsychotic activity .

HY-B1213A

Trimipramine	5-HT Receptor Bacterial	Neurological Disease
Trimipramine is a 5-HT receptor antagonist, with pK_i binding values of 6.39, 8.10, 4.66 for 5-HT_1C, 5-HT₂ and 5-HT_1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-101208

L-694247	5-HT Receptor	Neurological Disease Inflammation/Immunology
L-694247 is a selective 5-HT1D agonist with the pIC₅₀ values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors , respectively .

HY-101208A

L-694247 TFA	5-HT Receptor	Neurological Disease Inflammation/Immunology
L694247 (TFA) is a selective 5-HT1D agonist with pIC₅₀ values of 10.03, 8.64, 6.42, and 5.66 for 5-HT1D, 5-HT1A, 5-HT1C, and 5-HT1E receptors, respectively .

HY-108400

SCH-23390 maleate R-(+)-SCH-23390 maleate	Dopamine Receptor 5-HT Receptor Potassium Channel	Neurological Disease
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM .

HY-101009

Methiothepin maleate Metitepine maleate; Ro-8-6837 maleate	5-HT Receptor	Neurological Disease
Methiothepin maleate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-111491

Methiothepin Metitepine; Ro 8-6837	5-HT Receptor	Neurological Disease
Methiothepin (Metitepine; Ro 8-6837) is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

HY-105277

Amesergide	5-HT Receptor	Neurological Disease
Amesergide is a serotonin (5-HT1C/2) antagonist. Amesergide can result in a reduction of progeny body weight gains in maternal animals. Amesergide can be studied in research on depression .

HY-101324

MK-212 CPP	5-HT Receptor	Neurological Disease
MK-212 (CPP) is a centrally acting *5-HT_1C/5-HT₂* agonist. MK-212 can stimulate phosphoinositide hydrolysis in cerebral cortex .

HY-B0115R

Pizotifen (Standard) Pizotyline (Standard); BC-105 (Standard)	Reference Standards 5-HT Receptor	Neurological Disease
Pizotifen (Standard) is the analytical standard of Pizotifen. This product is intended for research and analytical applications. Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B0115S

Pizotyline-d3 Pizotyline-d₃; BC-105-d₃	5-HT Receptor Isotope-Labeled Compounds	Neurological Disease
Pizotyline-d₃ is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B1213S

Trimipramine-d3 maleate	Isotope-Labeled Compounds 5-HT Receptor Bacterial	Neurological Disease
Trimipramine-d₃ (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively .

HY-124117

LY 278584	5-HT Receptor	Neurological Disease
LY 278584 is a potent, highly selective 5-HT3 receptor antagonist with a K_i of 1.62 nM. LY 278584 has no activity on 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D, or 5-HT2 receptors .

HY-123704

CGS-12066 maleate	5-HT Receptor	Neurological Disease
CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT_1A, 5-HT_1B,5-HT_1C and 5-HT_1D with pEC₅₀ values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease .

HY-106904

Nexopamil	Calcium Channel 5-HT Receptor Dopamine Receptor	Cardiovascular Disease
Nexopamil is a calcium antagonist of Ca ²⁺ channel, 5HT₂, 5HT_1A, *5HT_1C* and dopamine D₂ receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease .

HY-B1213AR

Trimipramine (Standard)	Reference Standards 5-HT Receptor Bacterial	Neurological Disease
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-N9418R

Gibberellin A5 (Standard)	Phytohormone Reference Standards	Others
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

HY-B1213R

Trimipramine maleate (Standard)	Reference Standards 5-HT Receptor Bacterial	Neurological Disease
Trimipramine (maleate) (Standard) is the analytical standard of Trimipramine (maleate). This product is intended for research and analytical applications. Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively . Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC₅₀ values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively . Trimipramine maleate has vascular activity and anxiolytic efficacy .

HY-RS20957

Htr2c Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Htr2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Htr2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Htr2c Mouse Pre-designed siRNA Set A Htr2c Mouse Pre-designed siRNA Set A

HY-107836R

Methiothepin mesylate (Standard) Metitepine mesylate (Standard); Ro 8-6837 mesylate (Standard)	5-HT Receptor Reference Standards	Neurological Disease
Methiothepin (mesylate) (Standard) is the analytical standard of Methiothepin (mesylate). This product is intended for research and analytical applications. Methiothepin (Metitepine) mesylate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).

HY-101324AR

MK-212 monohydrochloride (Standard) CPP monohydrochloride (Standard)	Reference Standards 5-HT Receptor	Neurological Disease
MK-212 (monohydrochloride) (Standard) is the analytical standard of MK-212 (monohydrochloride). This product is intended for research and analytical applications. MK-212 (CPP) monohydrochloride is a centrally acting 5-HT1C/5-HT2 agonist. MK-212 monohydrochloride can stimulate phosphoinositide hydrolysis in cerebral cortex .

HY-106805

ICI 169369	5-HT Receptor	Others
ICI 169369 is an orally active, specific serotonin and 5-HT₂/5-HT_1C receptor competitive antagonist. ICI 169369 exhibits K_i values of 1.79 x 10 ⁻⁸ and 1.58 x 10 ⁻⁶ M for 5-HT₂ and 5-HT₁, respectively .

HY-RS27474

Htr2c Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Htr2c Rat Pre-designed siRNA Set A contains three designed siRNAs for Htr2c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Htr2c Rat Pre-designed siRNA Set A Htr2c Rat Pre-designed siRNA Set A

HY-RS06469

HTR2C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HTR2C Human Pre-designed siRNA Set A contains three designed siRNAs for HTR2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HTR2C Human Pre-designed siRNA Set A HTR2C Human Pre-designed siRNA Set A

Spiramide AMI-193	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Rosaceae Spiraea japonica Plants Disease Research Fields Source Classification	5-HT Receptor Dopamine Receptor
Spiramide (AMI-193) is a potent and selective antagonist of 5-HT₂ and dopamine D2 receptor, with K_is of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT₂ versus *5-HT_1C* (K_i=4300 nM) receptors. Spiramide exhibits antipsychotic activity .

Gibberellin A5 (Standard)	Rosaceae Plants Rosa canina Gremli ex Christ Source Classification	Phytohormone Reference Standards
Trimipramine (Standard) is the analytical standard of Trimipramine. This product is intended for research and analytical applications. Trimipramine is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine has vascular activity and anxiolytic efficacy .

Cat. No.	Product Name	Chemical Structure

HY-14940S

Volinanserin-d4 hydrochloride
Volinanserin-d₄ (hydrochloride) is the deuterium labeled Volinanserin hydrochlorid. Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a K_i of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity .

HY-B0115S

Pizotyline-d3
Pizotyline-d₃ is deuterated labeled Pizotifen (HY-B0115). Pizotifen (Pizotyline) is a potent 5-HT₂ receptor antagonist, with a high affinity for *5-HT_1C* binding site.

HY-B1213S

Trimipramine-d3 maleate
Trimipramine-d₃ (maleate) is the deuterium labeled Trimipramine maleate. Trimipramine maleate is a 5-HT receptor antagonist, with pKis of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (2) Dog (1)
Application:	IHC-P (1) ICC/IF (1) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83619

	HTR2C Antibody (YA3364) 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5HT1C; 5HT2C; 5HTR2C; 5Hydroxytryptamine 2C receptor; Htr1C; HTR2C	WB	Human, Mouse, Rat
	HTR2C Antibody (YA3364) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HTR2C.

HY-P811130

	5-HT2C Antibody HTR1C, HTR2C, 5-hydroxytryptamine receptor 2C, 5-HT-2C, 5-HT2C, 5-HTR2C, 5-hydroxytryptamine receptor 1C, Serotonin receptor 2C, 5-HT-1C, 5-HT1C	WB, IHC-P, ICC/IF	Human, Mouse, Dog
	5-HT2C Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to 5-HT2C.

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