65 Results for "

8-13

" in MedChemExpress (MCE) Product Catalog:
Products (65)

65 Results for "8-13" in MCE Product Catalog:

47
47 Publications Verification
Cat. No.: HY-D0711
CAS No.: 3599-32-4
Synonyms: Foxgreen; IC Green; Cardiogreen
Indocyanine green (Foxgreen) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm) .
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11
11 Cited Publications
Cat. No.: HY-15542A
CAS No.: 1286739-19-2
Purity:  99.36%
Target:  

PAK

Research Areas:  

Cancer

FRAX597 is a potent group I p21-activated Kinases (PAKs) inhibitor with IC50 of 8, 13 and 19 nM for PAK1, 2 and 3.
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1
1 Cited Publications
Cat. No.: HY-P0251
CAS No.: 60482-95-3
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

Neurotensin (8-13) is an active fragment of Neurotensin. Neurotensin(8-13) results in a decrease in cell-surface NT1 receptors (NTR1) density.
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1
1 Cited Publications
Cat. No.: HY-D1744
CAS No.: 2143933-81-5
ICG Maleimide is thiol reactive near infrared (NIR) fluorescent dye and used to generate a stable fluorescence signal in bioimaging (Ex/Em = 789/813 nm).
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Cat. No.: HY-W248594
CAS No.: 134127-48-3
Target:  

Fluorescent Dye

Research Areas:  

Others

IR 813 tosylate is a near-infrared (NIR) fluorescent dye and can be used for visualizing regional lymph nodes in mice .
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Cat. No.: HY-139300
CAS No.: 1203902-67-3
Synonyms: HMPL-813
Target:  

EGFR

Research Areas:  

Cancer

Epitinib (HMPL-813) is a selective, orally active, blood-brain barrier-permeable EGFR tyrosine kinase inhibitor. Epitinib is applicable to research on EGFR T790M-positive non-small cell lung cancer with brain metastasis and advanced solid tumors .
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Cat. No.: HY-147403S
CAS No.: 1637681-55-0
Synonyms: JNJ-61393215
Tebideutorexant is an OX1R-selective inhibitor with oral bioavailability and blood-brain barrier permeability, with human OX1R pKi 8.17 and rat OX1R pKi 8.13.Tebideutorexant selectively modulates OX1R, with no significant functional effect on OX2R. Tebideutorexant can be used for the research of panic and anxiety disorders .
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Cat. No.: HY-P2544
CAS No.: 139026-64-5
Synonyms: JMV438
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

[Lys8, Lys9]-Neurotensin (8-13) (JMV438), a Neurotensin analog, exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2, with Ki values of 0.33 nM and 0.95 nM for hNTS1 and hNTS2 receptors, respectively .
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Cat. No.: HY-W588722
CAS No.: 3024705-52-7
ICG-DBCO is a near-infrared fluorescent click chemistry reagent (Ex/Em = 789/813 nm), composed of Indocyanine green (ICG) (HY-D0711) and dibenzocyclooctyne (DBCO). ICG-DBCO enables copper-free, strain-promoted azide-alkyne cycloaddition (SPAAC) for labeling biomolecules such as antibodies, proteins and peptides, thereby facilitating deep tissue optical imaging .
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Cat. No.: HY-143319
CAS No.: 2364326-23-6
Purity:  99.40%
Target:  

EGFR

Research Areas:  

Cancer

SPH5030 is a selective and irreversible HER2 inhibitor. SPH5030 inhibits HER2 WT and EGFR WT with IC50s of 3.51 and 8.13 nM, respectively. SPH5030 shows excellent activities against HER2 mutants. SPH5030 can be used for the research of cancer .
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Cat. No.: HY-149591
CAS No.: 2600795-07-9
M4K2009 is an orally active, blood-brain barrier permeable type I ALK2 inhibitor, with an IC50 value of 8-13 nM against human ALK2. M4K2009 exhibits moderate off-target inhibitory activity against hERG potassium channels (Potassium Channel), with an IC50 of 8 μM against the human channel. M4K2009 can be used in studies related to diffuse intrinsic pontine glioma .
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Cat. No.: HY-P1256C
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse .
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Cat. No.: HY-D2616
ICG PEG2000 DBCO is a fluorescent probe containing Indocyanine green (ICG) (HY-D0711) dye. ICG PEG2000 DBCO contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups (Ex/Em=785/813 nm).
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Cat. No.: HY-D2617
ICG PEG5000 DBCO is a fluorescent probe containing Indocyanine green (ICG) (HY-D0711) dye. ICG PEG5000 DBCO contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups (Ex/Em=785/813 nm).
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Cat. No.: HY-101307
CAS No.: 864461-31-4
Synonyms: 7-Benzylidenenaltrexone maleate
Target:  

Opioid Receptor

Research Areas:  

Neurological Disease

BNTX (7-Benzylidenenaltrexone) maleate is a δ1-opioid receptor antagonist with the Kis of 0.1, 10.8, 13.3, and 58.6 nM for δ1, δ2-, μ-, and κ-opioid receptor, respectively. BNTX maleate shows antinociceptive activity .
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Cat. No.: HY-139300A
CAS No.: 2252334-12-4
Purity:  99.01%
Synonyms: HMPL-813 succinate
Target:  

EGFR

Research Areas:  

Cancer

Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. Epitinib succinate can be used for the research of cancer . Epitinib (succinate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No.: HY-P1256
CAS No.: 139026-66-7
Target:  

Neurotensin Receptor

Research Areas:  

Neurological Disease

JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.15 nM for inhibition of [ 125I]-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse .
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Cat. No.: HY-133124
CAS No.: 2337386-47-5
Purity:  99.43%
Target:  

PARP PI3K Apoptosis

Research Areas:  

Cancer

PARP/PI3K-IN-1 (compound 15) is a potent PARP/PI3K inhibitor with pIC50 values of 8.22, 8.44, 8.25, 6.54, 8.13, 6.08 for PARP-1, PARP-2, PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. PARP/PI3K-IN-1 is a highly effective anticancer compound targeted against a wide range of oncologic diseases .
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Cat. No.: HY-DY1027
CAS No.: 3599-32-4
Indocyanine green (Foxgreen) (solution) is a low toxicic fluorescent agent that has been widely used in medical diagnostics, such as determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography (Ex/Em = 785/813 nm) .
Solvent and concentration: DMSO: 10 mM
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Cat. No.: HY-D2610
ICG PEG2000 DSPE is a PEG phospholipid with Indocyanine green (ICG) (HY-D0711) dye used in protein/nucelic acid labeling and fluorescence microscopy. ICG PEG2000 DSPE can self-assemble in aqueous solution to form micelles/lipid bilayer and used to prepare liposomes or nanoparticles for nutrients delivery such as mRNA or DNA vaccine (Ex/Em=785/813 nm).
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