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AC4

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32

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5

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1

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2

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2

Isotope-Labeled Compounds

6

Click Chemistry

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-118297
    Ac4ManNAz (80% α isomer)
    5 Publications Verification

    		 Biochemical Assay Reagents Metabolic Disease
    Ac4ManNAz is an azido-containing metabolic glycoprotein labeling reagent. Ac4ManNAz can be used to selectively modify proteins. Ac4ManNAz can be used in cell labeling, tracking and proteomic analysis . Ac4ManNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ac4ManNAz (80% α isomer)
  • HY-W728531
    Ac4ManNAz
    Maximum Cited Publications
    14 Publications Verification

    		 Biochemical Assay Reagents p38 MAPK Potassium Channel Mitochondrial Metabolism Cancer
    Ac4ManNAz can be taken up by cells and is an azide-containing metabolic glycoprotein labeling reagent that selectively modifies proteins. Commonly used for cell labeling, tracking and proteomic analysis. Ac4ManNAz contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Ac4ManNAz can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Ac4ManNAz
  • HY-141128
    Ac4GalNAz

    		PROTAC Linkers Cancer
    Ac4GalNAz is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAz is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ac4GalNAz
  • HY-111815A
    N4-Acetylcytidine triphosphate sodium
    1 Publications Verification

    AC4CTP sodium

    		 Endogenous Metabolite Others
    N4-Acetylcytidine triphosphate sodium is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates .
    N4-Acetylcytidine triphosphate sodium
  • HY-124500
    AC-4-130
    5+ Cited Publications

    		 STAT Apoptosis Cancer
    AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML) .
    AC-4-130
  • HY-W039953
    Ac4GlcNAz

    N-azidoACetylglucosamine-tetraACylated

    		 Biochemical Assay Reagents Others
    Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.
    Ac4GlcNAz
  • HY-149552
    Ac4-5SGlcNAc

    		OGT Cancer
    Ac4-5SGlcNAc is an O-GlcNAc transferase (OGT) inhibitor. Ac4-5SGlcNAc converts intracellularly to UDP-5SGlcNAc, which competes with native UDP-GlcNAc (HY-148596) to block OGT catalytic activity, reduces cellular UDP-GlcNAc pools, and limits global protein O-GlcNAcylation. Ac4-5SGlcNAc reduces OGA levels via feedback, alters lectin signal intensities and glycan-related band masses. Ac4-5SGlcNAc can be used for the research of breast cancer .
    Ac4-5SGlcNAc
  • HY-110209
    AC4

    		TRP Channel Others
    AC4 is a trans antagonist upon voltageactivation of TRPV1 and as cis antagonist of TRPV1 currents upon stimulation with Capsaicin (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert .
    AC4
  • HY-174968B
    4-Arm-PEG10000-AC

    4-Arm-PEG10000-ACrylate

    		 Biochemical Assay Reagents Others
    4-Arm-PEG10000-AC (4-Arm-PEG10000-Acrylate) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
    4-Arm-PEG10000-AC
  • HY-178360
    NP1192

    		PROTACs Histone Acetyltransferase HIF/HIF Prolyl-Hydroxylase PD-1/PD-L1 PTEN Metabolic Disease Inflammation/Immunology Cancer
    NP1192 is a potent, selective PROTAC NAT10 degrader that depletes NAT10 protein and inhibits ac4C modification in cancer cells. NP1192 demonstrates dual inhibition of hypoxia-driven glycolysis and immunosuppression via NAT10/HIF-1α/PD-L1 axis disruption, achieving superior antitumor efficacy and synergizing with anti-PD-L1 both in vitro and in vivo. NP1192 can be used for ovarian, cervical, and glioblastoma cancer research. (Blue: CRBN ligand (HY-148834); Black: linker; Pink: NAT10 ligand (HY-16706)) .
    NP1192
  • HY-W114327
    N4-Acetyl-2'-O-methylcytidine

    		DNA/RNA Synthesis Others
    N4-Acetyl-2'-O-methylcytidine (ac4Cm) is an RNA with dual acetylation and methoxidation modifications found in thermophilic archaea. N4-Acetyl-2'-O-methylcytidine has been implicated in the adaptability of archaea in extreme environments, enhancing RNA stability through dual modification .
    N4-Acetyl-2'-O-methylcytidine
  • HY-140343
    Ac4GalNAl

    		PROTAC Linkers Cancer
    Ac4GalNAl is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Ac4GalNAl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ac4GalNAl
  • HY-W415798
    Ac4GalNAlk

    		Endogenous Metabolite Others
    Ac4GalNAlk is a weakly alkyne-labeled reagent for metabolic oligosaccharide engineering (MOE) that can be used to detect protein glycosylation. MOE reagents can be activated by cellular biosynthetic machinery into nucleotide sugars, which can be further traced through the introduction of glycoproteins in bioorthogonal chemistry. Ac4GalNAlk promotes nucleotide-sugar biosynthesis and increases bioorthogonal cell surface markers .
    Ac4GalNAlk
  • HY-111815
    N4-Acetylcytidine triphosphate

    AC4CTP

    		 Endogenous Metabolite Metabolic Disease
    N4-Acetylcytidine triphosphate is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and can be incorporated into multiple templates .
    N4-Acetylcytidine triphosphate
  • HY-141136
    Ac4GlcNAlk

    		PROTAC Linkers Cancer
    Ac4GlcNAlk is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .
    Ac4GlcNAlk
  • HY-W129441
    N-Acetyl-4-S-cysteaminylphenol

    N-AC-4-S-CAP

    		 DNA/RNA Synthesis Tyrosinase Thymidylate Synthase Others
    N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.
    N-Acetyl-4-S-cysteaminylphenol
  • HY-W145646
    Fmoc-L-Ser((Ac)4-β-D-Glc)-OH

    		Biochemical Assay Reagents Others
    Fmoc-L-Ser((Ac)4-β-D-Glc)-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Fmoc-L-Ser((Ac)4-β-D-Glc)-OH
  • HY-111815B
    N4-Acetylcytidine triphosphate sodium (solution)

    AC4CTP sodium (solution)

    		 Endogenous Metabolite Others
    N4-Acetylcytidine triphosphate sodium (solution) is an efficient substrate for T7 RNA polymerase-catalyzed transcription in vitro and can be incorporated into multiple templates .
    N4-Acetylcytidine triphosphate sodium (solution)
  • HY-173135
    PROTAC KDM4 degrader-1

    		PROTACs Histone Demethylase Apoptosis Cancer
    PROTAC KDM4 degrader-1 is a KDM4 PROTAC degrader that degrades KDM4A-C with DC50 values of 37.53, 39.93, and 49.41 nM, respectively, while sparing KDM4D. PROTAC KDM4 degrader-1 induces cell cycle arrest, apoptosis and antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 can be used for the research of esophageal cancer .
    PROTAC KDM4 degrader-1
  • HY-161160
    Ac4ManNDAz

    		Fluorescent Dye Others
    Ac4ManNDAz is a cell-permeable photocross-linking probe. Ac4ManNDAz can effectively compete with endogenous sialic acid for incorporation into cell surface glycoproteins and form cross-links with glycoprotein ligands under UV light irradiation. Ac4ManNDAz can be used to study interactions between glycoproteins .
    Ac4ManNDAz
  • HY-177738
    6'Nicotinate Ac4ManNAz

    		Drug Derivative Neurological Disease Metabolic Disease
    6'Nicotinate Ac4ManNAz (Compound 2) is a brain-penetrant carbohydrate-neuroactive heteromer conjugating Ac4ManNAz (HY-W728531) and Nicotinic acid (HY-B0143). 6'Nicotinate Ac4ManNAz can be used for the development of glycosylation-regulating agents or diagnostic probes that cross the BBB .
    6'Nicotinate Ac4ManNAz
  • HY-161913
    AC-4-248

    		Dopamine Transporter Neurological Disease
    AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively .
    AC-4-248
  • HY-P4688
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH

    		GnRH Receptor Endocrinology
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH is an important peptide hormone .
    (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH
  • HY-RS00330
    ADCY4 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    ADCY4 Human Pre-designed siRNA Set A contains three designed siRNAs for ADCY4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ADCY4 Human Pre-designed siRNA Set A
    ADCY4 Human Pre-designed siRNA Set A
  • HY-W768178
    2-Amino-2-deoxyglucose hydrochloride-13C2

    D-Glucosamine Hydrochloride-1,2-13C2

    		 Isotope-Labeled Compounds Others
    2-Amino-2-deoxyglucose hydrochloride- 13C2 (D-Glucosamine Hydrochloride-1,2- 13C2) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
    2-Amino-2-deoxyglucose hydrochloride-13C2
  • HY-174968A
    4-Arm-PEG5000-AC

    4-Arm-PEG5000-ACrylate

    		 Biochemical Assay Reagents Others
    4-Arm-PEG5000-AC (4-Arm-PEG5000-Acrylate) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
    4-Arm-PEG5000-AC
  • HY-W415799
    (2S)-Ac4GalNAl

    		Biochemical Assay Reagents Others
    (2S)-Ac4GalNAl can be used for the identification and characterization of specific surface groups of glycoproteins. The alkyne groups can react with azides via copper-catalyzed Click Chemistry. The acetyl groups on the glucose allow for easier penetration through the cell membrane.
    (2S)-Ac4GalNAl
  • HY-N9459R
    2-Amino-2-deoxyglucose hydrochloride (Standard)

    D-Glucosamine Hydrochloride (Standard)

    		 Others Reference Standards Others
    2-Amino-2-deoxyglucose (hydrochloride) (Standard) is (D-Glucosamine Hydrochloride (Standard)) the analytical standard of 2-Amino-2-deoxyglucose (hydrochloride) (HY-N9459). This product is intended for research and analytical applications. 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
    2-Amino-2-deoxyglucose hydrochloride (Standard)
  • HY-W766388
    2-Amino-2-deoxyglucose hydrochloride-13C6

    D-Glucosamine Hydrochloride-13C6

    		 Isotope-Labeled Compounds Others
    2-Amino-2-deoxyglucose hydrochloride- 13C6 (D-Glucosamine Hydrochloride- 13C6) is the 13C-labeled 2-Amino-2-deoxyglucose hydrochloride (HY-N9459). 2-Amino-2-deoxyglucose hydrochloride is a hexosamine hydrochloride can be used in the synthesis of cyclopropene-modified hexosamine derivative Ac4GlcNCyoc and Ac4GalNCyoc .
    2-Amino-2-deoxyglucose hydrochloride-13C6
  • HY-174968
    4-Arm-PEG2000-AC

    4-Arm-PEG2000-ACrylate

    		 Biochemical Assay Reagents Others
    4-Arm-PEG2000-AC (4-Arm-PEG2000-Acrylate) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
    4-Arm-PEG2000-AC
  • HY-174968C
    4-Arm-PEG20000-AC

    4-Arm-PEG20000-ACrylate

    		 Biochemical Assay Reagents Others
    4-Arm-PEG20000-AC (4-Arm-PEG20000-Acrylate) is a polymer consisting of a four-arm PEG core structure with acrylate groups attached to the ends of each PEG chain by chemical reaction, which can be used for drug delivery .
    4-Arm-PEG20000-AC
  • HY-183618
    DW-229

    		PROTACs Histone Demethylase Cancer
    DW-229 is a PROTAC degrader derived from Deferiprone (HY-B0568), targeting Fe(II)/α‑ketoglutarate‑dependent histone lysine demethylases (KDMs). DW-229 degrades KDM2A, KDM3A, KDM5B, KDM4A‑C, KDM5C, KDM6B in breast cancer cells. DW-229 shows IC50 < 0.5 μM against MCF‑7 cells and IC50 of 8.87 μM against MDA‑MB‑231 cells, with high cancer cell selectivity. DW-229 can be used for the research of breast cancer, liver cancer, prostate cancer, lung cancer .
    DW-229

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