AF1

By Targets:	Autophagy (3) Bacterial (2) Biochemical Assay Reagents (2) DNA/RNA Synthesis (4) Environmental Pollutants (1) Estrogen Receptor/ERR (1) FGFR (1) Fluorescent Dye (1) Fungal (2) Potassium Channel (1) Reference Standards (1) Small Interfering RNA (siRNA) (7)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Endocrinology (1) Infection (4) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (5) siRNAs (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136242

UT-34	Estrogen Receptor/ERR	Endocrinology Cancer
UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC₅₀ values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

HY-153736

NSC 194308	DNA/RNA Synthesis	Cancer
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations ^[1].

HY-178155

AP232	DNA/RNA Synthesis Autophagy	Cancer
AP232 is a selective *U2AF1-UHM* Inhibitor with an IC₅₀ of 7.96 μM. AP232 exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 can be used for the research of cancer, such as Leukemia ^[1].

HY-D2977

*AF-1*	Fluorescent Dye Autophagy Fungal	Infection
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH ^[1].

HY-178155A

AP232 dihydrochloride	DNA/RNA Synthesis Autophagy	Cancer
AP232 dihydrochloride is a selective *U2AF1-UHM* Inhibitor with an IC₅₀ of 7.96 μM. AP232 dihydrochloride exhibits 2.8-24-fold selectivity against other UHM-containing proteins. AP232 dihydrochloride exerts anti-leukemia activity and shows higher activities in cell lines carrying splicing factor mutations. AP232 dihydrochloride can induce leukemia cells G2/M and G1 arrest, impair lysosome acidification, and inhibit autophagy. AP232 dihydrochloride can be used for the research of cancer, such as Leukemia ^[1].

HY-W017241

1-Naphthalenemethanol 1-Hydroxymethylnaphthalene	Bacterial Biochemical Assay Reagents	Infection
1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research ^[1] .

HY-172923

FGFR-IN-20	FGFR	Cancer
Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC₅₀ of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2 ^[1].

HY-RS10896

POU2AF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
POU2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

POU2AF1 Human Pre-designed siRNA Set A POU2AF1 Human Pre-designed siRNA Set A

HY-RS15313

U2AF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2AF1 Human Pre-designed siRNA Set A U2AF1 Human Pre-designed siRNA Set A

HY-RS18687

U2af1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Mouse Pre-designed siRNA Set A U2af1 Mouse Pre-designed siRNA Set A

HY-W009815

δ-Dodecalactone δ-Laurolactone	Environmental Pollutants Fungal	Infection
δ-Dodecalactone can be obtained from L. plantarum AF1. δ-Dodecalactone exhibits potent antifungal activity against molds Aspergillus flavus, A. fumigatus, A. petrakii, A. ochraceus, A. nidulans, and Penicillium roqueforti. δ-Dodecalactone is a flavoring compound ^[1].

HY-RS06589

IFNGR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IFNGR2 Human Pre-designed siRNA Set A contains three designed siRNAs for IFNGR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IFNGR2 Human Pre-designed siRNA Set A IFNGR2 Human Pre-designed siRNA Set A

HY-RS04196

EFNA5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EFNA5 Human Pre-designed siRNA Set A contains three designed siRNAs for EFNA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EFNA5 Human Pre-designed siRNA Set A EFNA5 Human Pre-designed siRNA Set A

HY-RS11325

PSMD4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PSMD4 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PSMD4 Human Pre-designed siRNA Set A PSMD4 Human Pre-designed siRNA Set A

HY-120355A

AP14145 hydrochloride	Potassium Channel	Cardiovascular Disease
AP14145 hydrochloride is a potent K_Ca2 (SK) channel negative allosteric modulator with an IC₅₀ of 1.1 μM for K_Ca2.2 (SK2) and K_Ca2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF) .

HY-W017241R

1-Naphthalenemethanol (Standard) 1-Hydroxymethylnaphthalene (Standard)	Reference Standards Bacterial Biochemical Assay Reagents	Infection
1-Naphthalenemethanol (Standard) is the analytical standard of 1-Naphthalenemethanol (HY-W017241). This product is intended for research and analytical applications. 1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research ^[1] .

HY-RS25173

U2af1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

U2af1 Rat Pre-designed siRNA Set A U2af1 Rat Pre-designed siRNA Set A

HY-139499

Sudemycin D6	DNA/RNA Synthesis	Cancer
Sudemycin D6 is a pre-mRNA splicing modulator with potent antitumour activity. Sudemycin D6 changes splice site usage of the DUSP11 and *SRRM1* pre-mRNA. Sudemycin D6 reduces survival and alters cell cycle in haematopoietic cells expressing mutant U2AF1. Sudemycin D6 attenuates mutant U2AF1-induced haematopoietic progenitor cell expansion in U2AF1(S34F) transgenic mice. Sudemycin D6 can be used for cancer research ^[1] .

Cat. No.	Product Name	Type

HY-D2977

*AF-1*	Fluorescent Dye
AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P2135

Neuropeptide AF1	Peptides	Neurological Disease
Neuropeptide AF1 is a FMRFamide-like neuropeptide. Neuropeptide AF1 can be isolated from head extracts of the nematode Ascaris suum. Neuropeptide AF1 rapidly and reversibly abolishs slow membrane potential oscillations of identified ventral and dorsal inhibitory motoneurons and selectively reduces their input resistances. Neuropeptide AF1 inhibits locomotory movements in intact Ascaris ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W017241

1-Naphthalenemethanol 1-Hydroxymethylnaphthalene	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Plants Inflammation/Immunology Disease Research Fields Source Classification	Bacterial Biochemical Assay Reagents
1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research ^[1] .

HY-W017241R

1-Naphthalenemethanol (Standard) 1-Hydroxymethylnaphthalene (Standard)	Structural Classification Natural Products Microorganisms other families Plants Source Classification	Reference Standards Bacterial Biochemical Assay Reagents
1-Naphthalenemethanol (Standard) is the analytical standard of 1-Naphthalenemethanol (HY-W017241). This product is intended for research and analytical applications. 1-Naphthalenemethanol is a hydroxyl-substituted naphthalene derivative. 1-Naphthalenemethanol can be extracted from the root of Annona senegalensis. 1-Naphthalenemethanol is a photolysis product of 1-napthaleneacetic acid. 1-Naphthalenemethanol, together with PAPS, provides some protection against the irreversible inactivation of AST IV caused by N-OH-2AF. 1-Naphthalenemethanol can be used in antibacterial research ^[1] .

Species:	Human (3) Mouse (2)
Tag:	His (4) Fc (1)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P74852

	IFN-gamma R2 Protein, Mouse (HEK293, His, solution) 2 Publications Verification Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1	Mouse	HEK293
	IFN-gamma R2, one of the subunit of IFN-gamma receptor, is a receptor for IFN-gamma. IFN-gamma R2 is the signal-transducing chain of the IFN-gamma receptor. IFN-gamma R2 forms the functional receptor with IFN-gamma R1. Upon binding with IFN-gamma, IFN-gamma R2 and IFN-gamma R1 oligomerize and transphosphorylate. Then, the downstream signaling components JAK1 and JAK2 are phosphorylated and activated, and STAT1 is phosphorylated. Phosphorylated STAT1 translocates to the nucleus, where it regulates the expression of IFN-responsive genes (e.g. CD54). IFN-gamma R2 Protein, Mouse (HEK293, His) is a recombinant mouse IFN-gamma R2 (M1-V243) with C-terminal His tag, which is produced in HEK293 cells.

HY-P74852A

	IFN-gamma R2 Protein, Mouse (HEK293, His) Interferon gamma receptor 2; IFN-γ Receptor II; IFNGR2; IFNGT1	Mouse	HEK293

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; Transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P700485

	EPS15 Protein, Human (His) Eps15 epidermal; growth factor receptor pathway substrate 15; 2410112D09Rik; epidermal growth factor receptor substrate 15; epidermal growth factor pathway substrate 15; protein AF-1p	Human	E. coli
	EPS15 is a multifunctional protein that regulates cell growth, controls mitotic signaling, and contributes to receptor tyrosine kinase (RTK) internalization, particularly affecting EGFR. As a clathrin adapter, EPS15 is critical for the assembly and maturation of clathrin-coated pits (CCP), affecting the endocytosis of molecules such as ITGB1 and transferrin receptor (TFR). EPS15 Protein, Human (His) is the recombinant human-derived EPS15 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-6*His labeled tag.

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Host:	Mouse (3) Rabbit (2)
Reactivity:	Human (5) Rat (1) Mouse (2)
Application:	IHC-P (4) ICC/IF (2) IP (1) WB (3) FC (2) ELISA (1)
Isotype:	IgG (2) IgG2a (1) IgG2b (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (5) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82370

	PSMD4 Antibody (YA2115) PSMD4; AF; AF-1; ASF; MCB1; Rpn10; S5A; pUB-R5	WB, FC, IP	Human, Mouse, Rat
	PSMD4 Antibody (YA2115) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PSMD4.

HY-P88211

	IFNGR2 Antibody (YA7895) AF-1; IFGR2; IFNGT1; IMD28	IHC-P	Human
	IFNGR2 Antibody (YA7895) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IFNGR2.

HY-P88211A

	IFNGR2 Antibody (YA7895)(PBS only) AF-1; IFGR2; IFNGT1; IMD28	IHC-P	Human
	IFNGR2 Antibody (YA7895) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to IFNGR2.

HY-P82467

	BOB1 Antibody (YA2212) BOB 1; BOB-1; OBF 1; OBF1; OCA B; OCA-B; OCAB; OCT binding factor 1; Pou2AF1	WB, IHC-P, ICC/IF, FC	Human
	BOB1 Antibody (YA2212) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BOB1.

HY-P85829

	BOB1 Antibody (YA5521) B cell Oct binding protein 1; B cell specific coactivator OBF 1; B cell specific coactivator OBF1; B-cell-specific coactivator OBF-1; BOB 1; BOB-1; OBF 1; OBF1; OBF1_HUMAN; OCA B; OCA-B; OCAB; OCT binding factor 1; OCT-binding factor 1; POU class 2 associating factor 1; POU domain class 2 associating factor 1; POU domain class 2-associating factor 1; Pou2AF1	IHC-P, WB, ICC/IF, ELISA	Human, Mouse
	BOB1 Antibody (YA5521) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BOB1.

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Cat. No.	Product Name		Classification

HY-RS10896

POU2AF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
POU2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for POU2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS15313

U2AF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
U2AF1 Human Pre-designed siRNA Set A contains three designed siRNAs for U2AF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18687

U2af1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
U2af1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06589

IFNGR2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IFNGR2 Human Pre-designed siRNA Set A contains three designed siRNAs for IFNGR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS04196

EFNA5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
EFNA5 Human Pre-designed siRNA Set A contains three designed siRNAs for EFNA5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11325

PSMD4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PSMD4 Human Pre-designed siRNA Set A contains three designed siRNAs for PSMD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25173

U2af1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
U2af1 Rat Pre-designed siRNA Set A contains three designed siRNAs for U2af1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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