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Results for "

AID

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (7) Akt (2) Amyloid-β (1) Apoptosis (4) Bacterial (3) Bcl-2 Family (1) Biochemical Assay Reagents (13) Calcium Channel (1) Caspase (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (2) Cytochrome P450 (1) DNA Stain (1) Drug Metabolite (1) Endogenous Metabolite (7) Environmental Pollutants (4) Epigenetic Reader Domain (1) ERK (4) Fluorescent Dye (4) Fungal (1) GABA Receptor (2) Histamine Receptor (1) Histone Methyltransferase (1) HIV (7) HIV Protease (2) Influenza Virus (2) Integrin (2) Isotope-Labeled Compounds (7) Keap1-Nrf2 (2) mAChR (4) nAChR (11) NF-κB (1) p38 MAPK (2) Parasite (1) Phosphatase (2) Photosensitizer (1) PI3K (2) PKA (2) PKC (2) PPAR (2) Reactive Oxygen Species (ROS) (3) Reference Standards (12) Sirtuin (2) Small Interfering RNA (siRNA) (3) STAT (2) TNF Receptor (2) Toll-like Receptor (TLR) (2)
By Research Areas:	Cancer (20) Cardiovascular Disease (5) Endocrinology (7) Infection (7) Inflammation/Immunology (21) Metabolic Disease (14) Neurological Disease (23)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

5-Ph-IAA Maximum Cited Publications 52 Publications Verification	Epigenetic Reader Domain	Cancer
5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression .

Methacholine chloride 5+ Cited Publications Acetyl-β-methylcholine chloride	mAChR	Others
Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

Linarin 4 Publications Verification Buddleoside; Linarine	TNF Receptor Cholinesterase (ChE) PKA Apoptosis Bacterial HIV Influenza Virus	Infection Neurological Disease Inflammation/Immunology Cancer
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer .

Varenicline 1 Publications Verification CP 526555	nAChR	Neurological Disease Inflammation/Immunology Cancer
Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

Darunavir 15+ Cited Publications TMC114; UIC-94017	HIV HIV Protease	Infection Inflammation/Immunology
Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC₅₀ = 0.003 μM; IC₉₀ = 0.009 μM) with minimal cytotoxicity .

Toluidine Blue 3 Publications Verification Toluidine Blue O	Fluorescent Dye	Cancer
Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer .

Varenicline Tartrate 1 Publications Verification CP 526555-18	nAChR ERK p38 MAPK	Others Neurological Disease Cancer
Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

Copper(II) Gluconate 2 Publications Verification	Environmental Pollutants Biochemical Assay Reagents	Others
Copper(II) Gluconate is a non-toxic copper supplement aid. Copper(II) Gluconate is the copper salt of D-gluconic acid. Copper(II) Gluconate as a precursor catalyst that can be used in the photo-induced polymerisation of acrylates .

Celite Diatomaceous earth	Environmental Pollutants Biochemical Assay Reagents	Metabolic Disease
Celite (Diatomaceous earth) is a filter aid. Celite induces hepatic tryptophan oxygenase activity and reduces hepatic glycogen in mouse experiments. Celite can be used for studies of endotoxemia .

L-5-Hydroxytryptophan 3 Publications Verification L-5-HTP; Oxitriptan	Endogenous Metabolite	Neurological Disease Metabolic Disease
L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .

Bacillibactin Corynebactin	Bacterial Fungal	Infection
Bacillibactin (Corynebactin) is a cyclic tricatecholate siderophore. Bacillibactin’s primary function is to facilitate bacterial iron acquisition by chelating iron ions (Fe ³⁺) from the environment, thereby aiding bacterial survival under iron-limited conditions. Bacillibactin exhibits direct antimicrobial activity, such as inhibition of the growth of the producing bacteria Pseudomonas aeruginosa and Aeromonas veronae, as well as plant pathogens such as Pseudomonas syringae.Bacillibactin can be used in antibacterial and antifungal research .

(R)-Sulforaphane 2 Publications Verification L-Sulforaphane	Keap1-Nrf2 Bcl-2 Family Caspase Reactive Oxygen Species (ROS) NF-κB	Inflammation/Immunology Cancer
(R)-Sulforaphane (L-Sulforaphane) is a orally active, potent inducer of the Keap1/Nrf2/ARE pathway, exhibiting antioxidant and anticancer activities. (R)-Sulforaphane primarily functions by upregulating phase II detoxifying enzymes in cells, aiding in the removal of carcinogens and combating oxidative stress. (R)-Sulforaphane is capable of modulating gene expression, influencing various signaling pathways, including Nrf2, NF-κB, and AP-1. (R)-Sulforaphane can be used in studies of tumor biology, antioxidant defense mechanisms, as well as inflammation and immune responses .

Titanium(IV) oxide Titanium dioxide	Environmental Pollutants Reactive Oxygen Species (ROS) Photosensitizer	Others
Titanium(IV) oxide is a photosensitizer and photocatalyst. Titanium(IV) oxide can be used as a pharmaceutical excipient such as a flow aid, coating agent, sunscreen, colorant, etc. Pharmaceutical excipients or pharmaceutical excipients refer to other chemical substances used in the pharmaceutical process other than the drug ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations that can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism and elimination (ADME) process of co-administered drugs. Titanium(IV) oxide can use light energy to generate electron-hole pairs to degrade pollutants. Photons excite electrons in TiO₂ to generate active oxygen species (such as ·OH and ·O₂ ^-), thereby oxidizing and mineralizing pollutants such as organic compounds and heavy metals. TiO₂ can be used in the research of environmental remediation fields such as water treatment, air purification and self-cleaning materials .

Alfuzosin 1 Publications Verification SL 77499	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin can be used in study of benign prostatic hyperplasia (BPH) .

LLY-507 10+ Cited Publications	Histone Methyltransferase	Cancer
LLY-507 is a potent and selective inhibitor of protein-lysine methyltransferase SMYD2. LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC₅₀ <15 nM. LLY-507 serves as a valuable chemical probe to aid in the dissection of SMYD2 function in cancer and other biological processes .

Isovaleramide 1 Publications Verification 3-Methylbutanamide	GABA Receptor	Neurological Disease Metabolic Disease
Isovaleramide (3-Methylbutanamide) is an orally active anticonvulsant. Isovaleramide inhibits alcohol dehydrogenase (ADH) activity and regulates GABAergic system. Isovaleramide reduces acute kidney injury. Isovaleramide has antiepileptic, anxiolytic, sedative and hypnotic effects[1] .

Cy3-dCTP	Fluorescent Dye DNA Stain	Others
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

Ac4GlcNAz N-azidoacetylglucosamine-tetraacylated	Biochemical Assay Reagents	Others
Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.

Varenicline Hydrochloride CP 526555 hydrochloride	nAChR	Neurological Disease Inflammation/Immunology Cancer
Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

Phellopterin	Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Inflammation/Immunology
Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus .

Alfuzosin hydrochloride 1 Publications Verification SL 77499-10	Adrenergic Receptor	Endocrinology
Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

β-Amyloid peptide(16-20) KLVFF	Amyloid-β	Neurological Disease
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH₂ residues added at N- and C-terminal ends to aid solubility) .

Toluidine Blue (purity 36%) 3 Publications Verification Toluidine Blue O (purity 36%)	Fluorescent Dye	Others Cancer
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

L-5-Hydroxytryptophan-d3 L-5-HTP-d₃; Oxitriptan-d₃	Endogenous Metabolite	Neurological Disease Metabolic Disease
L-5-Hydroxytryptophan-d₃ is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .

Varenicline dihydrochloride CP 526555 dihydrochloride	nAChR	Neurological Disease Inflammation/Immunology Cancer
Varenicline (CP 526555-18) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α7β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

AEM1	Keap1-Nrf2	Cancer
AEM1 is an Nrf2 inhibitor with anti-tumor and oral activity. AEM1 promotes the differentiation of HepaRG cells towards mature liver cells, aiding in the recovery of damaged liver .

Methyl 3-oxopentanoate	Biochemical Assay Reagents	Others
Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

L-5-Hydroxytryptophan (Standard) 3 Publications Verification L-5-HTP (Standard); Oxitriptan (Standard)	Endogenous Metabolite Reference Standards	Neurological Disease Metabolic Disease
L-5-Hydroxytryptophan (Standard) is the analytical standard of L-5-Hydroxytryptophan. This product is intended for research and analytical applications. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .

Kieselguhr, soda ash flux-calcined	Biochemical Assay Reagents	Others
Kieselguhr, soda ash flux-calcined is a filter aid.

Purified Siliceous Earth, for injection Purified Diatomaceous earth, for injection; Purified Diatomaceous silica, for injection	Biochemical Assay Reagents	Metabolic Disease
Purified Siliceous Earth, for injection (Purified Diatomaceous earth, for injection; Purified Diatomaceous silica, for injection) is a filter aid.

BTT-266	Calcium Channel	Neurological Disease
BTT-266 is an antagonist forcalcium channel, through suppression of the Ca_Vα_1-AID-Ca_Vβ₃ interaction, with a K_i of 1.4 μM. BTT-266 modulates the activation of voltage-dependent Ca_V2.2. BTT-266 exhibits analgesic efficacy against neuropathic pain in rats model .

Toluidine blue (ZnCl2)	Biochemical Assay Reagents	Others
Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

L-5-Hydroxytryptophan-d4 L-5-HTP-d₄; Oxitriptan-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
L-5-Hydroxytryptophan-d₄ (L-5-HTP-d₄; Oxitriptan-d₄) is a deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia .

11R-CaN-AID	Phosphatase	Others
11R-CaN-AID is a potent and cell permeant inhibitor of calcineurin .

Betulin diacetate Betulin 3,28-diacetate	HIV	Infection Inflammation/Immunology Cancer
Betulin diacetate, a triterpene and derivative of Betulin, is an anti-AID agent and also possesses anti-cancer activity .

Magnesium trisilicate	Environmental Pollutants Biochemical Assay Reagents	Others
Magnesium trisilicate, is an antacid and filter aid. Magnesium trisilicate is a biomaterial or organic compound that can be used in life science research .

MNG-14a	Biochemical Assay Reagents	Others
MNG-14a is an amphiphilic compound that can be used to aid the isolation of membrane proteins, and functional and structural determination of membrane proteins .

11R-CaN-CON	Phosphatase	Others
11R-CaN-CON is a control inactive peptide and can be used as a negative control for 11R-CaN-AID (HY-P10167) .

Darunavir (Standard) TMC114 (Standard); UIC-94017 (Standard)	HIV HIV Protease Reference Standards	Infection Inflammation/Immunology
Darunavir (Standard) is the analytical standard of Darunavir. This product is intended for research and analytical applications. Darunavir (TMC114), an orally active next generation HIV protease inhibitor, has a similar antiviral activity against the mutant and the wild-type viruses. Darunavir (TMC114) is potent against laboratory HIV-1 strains and primary clinical isolates (IC50 = 0.003 μM; IC90 = 0.009 μM) with minimal cytotoxicity .

Linarin (Standard) Buddleoside (Standard); Linarine (Standard)	TNF Receptor Reference Standards Cholinesterase (ChE) PKA Apoptosis Bacterial HIV Influenza Virus	Infection Neurological Disease Inflammation/Immunology Cancer
Linarin (Standard) is the analytical standard of Linarin. This product is intended for research and analytical applications. Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.

Alfuzosin hydrochloride (Standard) SL 77499-10 (Standard)	Reference Standards Adrenergic Receptor	Endocrinology
Alfuzosin (hydrochloride) (Standard) is the analytical standard of Alfuzosin (hydrochloride). This product is intended for research and analytical applications. Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) .

Methacholine bromide Acetyl-β-methylcholine bromide	mAChR	Cardiovascular Disease
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

Methacholine chloride (Standard) Acetyl-β-methylcholine chloride (Standard)	Reference Standards mAChR	Others
Methacholine (chloride) (Standard) is the analytical standard of Methacholine (chloride). This product is intended for research and analytical applications. Methacholine (Acetyl-β-methylcholine) choride is a potent muscarinic-3 (M3) agonist. Methacholine choride acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine choride shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine choride can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates .

Varenicline Tartrate (Standard) CP 526555-18 (Standard)	Reference Standards nAChR ERK p38 MAPK	Others Neurological Disease
Varenicline (Tartrate) (Standard) is the analytical standard of Varenicline (Tartrate). This product is intended for research and analytical applications. Varenicline (CP 526555) is an orally active partial agonist of α4β2 nicotinic acetylcholine receptor (α4β2 nAChR, IC₅₀ = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of α6β2 nAChR and a full agonist of α6β2 nAChR. Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation .

Phellopterin (Standard)	Reference Standards Akt Sirtuin Integrin STAT PI3K Apoptosis ERK PPAR PKC Toll-like Receptor (TLR) HIV	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phellopterin (Standard) is the analytical standard of Phellopterin. Phellopterin, an orally active furocoumarin with multiple biological activities. Phellopterin is a partial agonist of the central benzodiazepine receptors. Phellopterin exerts anti-inflammatory effects by upregulating SIRT1, downregulating ICAM-1 (reducing chronic inflammation, aiding diabetic ulcer healing), inhibiting STAT3 phosphorylation (easing atopic dermatitis inflammation), regulating Akt/PKC pathways (lowering TNF-α-induced VCAM-1 to block monocyte adhesion), and inhibiting TLR4/NF-κB pathway and macrophage M2 polarization (alleviating colitis-related cancers). Phellopterin suppresses ovarian cancer progression via inhibiting the PU.1/CLEC5A/PI3K-AKT loop (inducing cell cycle arrest, apoptosis, DNA damage). Phellopterin alleviates murine diabetes by promoting adipocyte differentiation and increasing PPARγ. Phellopterin also has anti-HSV-1 activity. Phellopterin can be used for studying anti-inflammation, anti-cancer (e.g., ovarian cancer, colitis cancer), blood glucose lowering, anti-diabetes, and anti-virus.

GV-150013	Cholecystokinin Receptor	Others
GV-150013 is a selective CCK-B receptor antagonist. GV-150013 has sleep aid effect .

Cat. No.	Product Name

HY-L096

Inactive Ingredient Library

185 compounds

An inactive ingredient is any component of a drug product other than the active ingredient. Inactive ingredients are added during the manufacturing process of pharmaceutical products such as tablets, capsules, suppositories, and injections. In new drug development, once an inactive ingredient has appeared in an approved drug product for a particular route of administration, the inactive ingredient is not considered new and may require a less extensive review the next time it is included in a new drug product.

MCE offers a unique collection of 185 inactive ingredients, which only contain inactive ingredients of the final dosage forms of the drug. MCE Inactive Ingredient library is a powerful tool for aiding in the development of the drug and saving unnecessary time.

HY-L906

Norepinephrine Transporter (NET) Compound Library

647 compounds

On May 15, 2024, "Dimerization and antidepressant recognition at noradrenaline transporter" was published online by Nature. The research findings were an effort from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. This study unraveled the important neural system target - the noradrenaline transporter (NET), obtaining the binding modes of human NET homodimers with the natural substrate norepinephrine (NE) and six selective antidepressants. It laid an important theoretical foundation for understanding the physiological regulation mechanisms of NET and other monoamine transporters.

The Norepinephrine Transporter (NET) Compound Library is obtained by computer-aided virtual screening based on the HY-L901 compound library . The specific screening process includes molecular docking screening, key pharmacophore screening, and CNS-MPO screening, which can be used for new drug discovery targeting the noradrenaline transporter.

Cat. No.	Product Name	Type

HY-D1725

Cy3-dCTP	Fluorescent Dye
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-D0220A

Toluidine Blue (purity 36%)

3 Publications Verification

Toluidine Blue O (purity 36%)

Fluorescent Dye

Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-W250143

Toluidine blue (ZnCl2)

Fluorescent Dye

Toluidine blue (ZnCl2) is a basic thiazine dye commonly used as a biological stain for microscopy. It has a deep bluish-purple color and is commonly used to stain nucleic acids such as DNA and RNA, as well as to stain mast cells, cartilage, and other connective tissues. Toluidine blue (ZnCl2) stains the acidic components of these tissues, such as sulfated or carboxylated mucopolysaccharides. It is frequently used in histology, cytology, and pathology applications to aid in the diagnosis of various diseases and conditions. The dye is usually applied to tissue sections prior to microscopic examination and can be differentiated using an acidic alcohol solution. Toluidine blue (ZnCl2) is a relatively simple and inexpensive stain with good reproducibility, making it a popular choice for many laboratories.

Cat. No.	Product Name	Type

HY-W010394

Methyl 3-oxopentanoate

Biochemical Assay Reagents

Methyl 3-oxopentanoate, which is also known as diethyl acetylmalonate or MEAM, Methyl 3-oxopentanoate is commonly used as a building block for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and flavorings, and it can also Used as a reagent in organic chemical reactions, especially the formation of carbon-carbon bonds through malonate synthesis, the researchers also investigated the potential use of Methyl 3-oxopentanoate in the development of chiral auxiliaries that can aid in the selection of Controlling the stereochemistry of chemical reactions.

HY-W111589F

Kieselguhr, soda ash flux-calcined	Biochemical Assay Reagents
Kieselguhr, soda ash flux-calcined is a filter aid.

HY-Y1212A

Purified Siliceous Earth, for injection Purified Diatomaceous earth, for injection; Purified Diatomaceous silica, for injection	Biochemical Assay Reagents
Purified Siliceous Earth, for injection (Purified Diatomaceous earth, for injection; Purified Diatomaceous silica, for injection) is a filter aid.

HY-W115757

Magnesium trisilicate	Biochemical Assay Reagents
Magnesium trisilicate, is an antacid and filter aid. Magnesium trisilicate is a biomaterial or organic compound that can be used in life science research .

HY-W039920

1-Amino-1-deoxy-β-D-galactose, 98% β-D-Galactosylamine, 98%	Biochemical Assay Reagents
1-Amino-1-deoxy-β-D-galactose, 98% is a galactose analog used as a competitive inhibitor to aid in the separation, purification, identification, differentiation, and characterization of β-D-galactosidase and galactose oxidase.

Cat. No.	Product Name	Target	Research Area

HY-P5124

β-Amyloid peptide(16-20) KLVFF	Amyloid-β	Neurological Disease
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH₂ residues added at N- and C-terminal ends to aid solubility) .

HY-P10167

11R-CaN-AID	Phosphatase	Others
11R-CaN-AID is a potent and cell permeant inhibitor of calcineurin .

HY-P10168

11R-CaN-CON	Phosphatase	Others
11R-CaN-CON is a control inactive peptide and can be used as a negative control for 11R-CaN-AID (HY-P10167) .

HY-P11743

Mitochondrial penetrating peptide	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Metabolic Disease
Mitochondrial penetrating peptide is a peptide sequence (FrFKFrFK-CONH₂) that selectively transports cargo into mitochondria. Mitochondrial penetrating peptide possesses special physicochemical properties, enabling it to selectively translocate dinuclear Ru (II) polypyridine complexes into mitochondria of living mammalian cells without the aid of solvents or membrane permeabilization treatments, thus achieving precise mitochondrial localization and enrichment of the complexes while excluding their distribution in the nucleus. Mitochondrial penetrating peptide enables dynamic monitoring of mitochondrial oxygen concentration and ROS production in living mammalian cells via changes in the luminescence lifetime of the coupled Ru (II) complex .

Cat. No.	Product Name

HY-K0603

Alcian Blue Staining Solution (pH 1.0)
MCE Alcian Blue Staining Solution (pH 1.0) is commonly used for selective detection of sulfated mucins in histological research, including cartilage staining, mucin type differentiation, and aiding in the identification of mucinous epithelial tumors.

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HY-P72074

	AICDA Protein, Mouse (His-Myc) Aicda; AID; Single-stranded DNA cytosine deaminase; EC 3.5.4.38; Activation-induced cytidine deaminase; AID; Cytidine aminohydrolase	Mouse	E. coli
	AICDA Protein, Mouse (His-Myc) is an enzyme that mediates affinity maturation and facilitates DNA demethylation in germinal center (GC) B cells. AICDA Protein overexpression causes more aggressive disease in BCL2-driven murine lymphomas.

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Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
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Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Host:	Mouse (1) Rabbit (6)
Reactivity:	Human (6) Mouse (6) human (1)
Application:	IHC-P (6) ICC/IF (2) IF-Tissue (6) IP (1) DotBlot (2) WB (7) ELISA (1)
Isotype:	IgG (6) IgG2b (1)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (6) Recombinant (6)
Modification:	Unmodified (7)

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HY-P89887

	AID Antibody (YA9231)	WB, ICC/IF, IF-Tissue, IP, ELISA	human
	AID Antibody (YA9231) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to AID.

HY-P83753

	beta Amyloid 1-40 Antibody (YA3554) A4 antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody; Aβ;	WB, IHC-P, IF-Tissue	Human, Mouse
	beta Amyloid 1-40 Antibody (YA3554) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-40.

HY-P83754

	beta Amyloid 1-42 Antibody (YA3555) A4 antibody; A4_HUMAN antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody Aβ	WB, IHC-P, IF-Tissue	Human, Mouse
	beta Amyloid 1-42 Antibody (YA3555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-42.

HY-P83755

	beta Amyloid Antibody (YA3556) A4 antibody; A4_HUMAN antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody; Aβ;	WB, IHC-P, ICC/IF, DotBlot	Human, Mouse
	beta Amyloid Antibody (YA3556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid.

HY-P83754A

	beta Amyloid 1-42 Antibody (YA3555)(PBS only) A4 antibody; A4_HUMAN antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody Aβ	WB, IHC-P, IF-Tissue	Human, Mouse
	beta Amyloid 1-42 Antibody (YA3555) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-42.

HY-P83753A

	beta Amyloid 1-40 Antibody (YA3554)(PBS only) A4 antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody; Aβ;	WB, IHC-P, IF-Tissue	Human, Mouse
	beta Amyloid 1-40 Antibody (YA3554) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid 1-40.

HY-P83755A

	beta Amyloid Antibody (YA3556)(PBS only) A4 antibody; A4_HUMAN antibody; AAA antibody; ABETA antibody; ABPP antibody; AICD-50 antibody; AICD-57 antibody; AICD-59 antibody; AID(50) antibody; AID(57) antibody; AID(59) antibody; Alzheimer disease amyloid protein antibody; Amyloid intracellular domain 50 antibody; Amyloid intracellular domain 57 antibody; Amyloid intracellular domain 59 antibody; APP antibody; APPI antibody; Beta amyloid protein 42 antibody; Beta APP42 antibody; Beta-APP40 antibody; Beta-APP42 antibody; C31 antibody; Cerebral vascular amyloid peptide antibody; CVAP antibody; Gamma-CTF(50) antibody; Gamma-CTF(57) antibody; Gamma-CTF(59) antibody; PN-II antibody; PreA4 antibody; Protease nexin-II antibody; S-APP-alpha antibody; S-APP-beta antibody; Aβ;	WB, IHC-P, IF-Tissue, DotBlot	Human, Mouse
	beta Amyloid Antibody (YA3556) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Amyloid.

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Host
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-D1725

Cy3-dCTP		Labeling and Fluorescence Imaging
Cy3-dCTP is a directly fluorescently labeled deoxyribonucleotide, in which Cy3 is a cyanine fluorescent dye. Cy3-dCTP is used for direct enzymatic labeling of DNA and cDNA: with the aid of DNA polymerases, this modified nucleotide is incorporated into the extending DNA strand during processes such as reverse transcription, PCR, nick translation or random primer labeling .

HY-W039953

Ac4GlcNAz N-azidoacetylglucosamine-tetraacylated		Azide
Ac4GlcNAz (N-azidoacetylglucosamine-tetraacylated) is an azido-tagged analogue of N-acetylglucosamine (GlcNAC). It features azide functionality on the N-acyl side chain and is acetylated to aid in cell membrane permeation. Once in the cell, the acetylated compound is deprotected and takes part in the hexosamine biosynthetic pathway by action of GlcNAc kinase. The resulting modified proteins are detected by the addition of fluorescent tags under Cu(I)-catalyzed azide-alkyne cycloaddition conditions.

Cat. No.	Product Name		Classification

HY-Y1212

Celite Diatomaceous earth		Others
Celite (Diatomaceous earth) is a filter aid. Celite induces hepatic tryptophan oxygenase activity and reduces hepatic glycogen in mouse experiments. Celite can be used for studies of endotoxemia .

HY-RS19405

Aicda Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Aicda Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aicda gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS00488

AICDA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
AICDA Human Pre-designed siRNA Set A contains three designed siRNAs for AICDA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS25897

Aicda Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Aicda Rat Pre-designed siRNA Set A contains three designed siRNAs for Aicda gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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