25 Results for "

ActRIIB

" in MedChemExpress (MCE) Product Catalog:
Products (25)

25 Results for "ActRIIB" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P99720
CAS No.: 1373715-00-4
Synonyms: ACE-536; luspatercept–aamt

Target:  

TGF-beta/Smad

Research Areas:  

Cardiovascular Disease

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
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3
3 Cited Publications
Cat. No.: HY-P99355
CAS No.: 1356922-05-8
Synonyms: Anti-ACVR2B Reference Antibody; BYM338

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII), with KDs of 1.7 pM and 434 pM for human ActRIIB and ActRIIA, respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness .
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1
1 Cited Publications
Cat. No.: HY-P99588
CAS No.: 705287-60-1
Synonyms: MYO-029

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research .
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Cat. No.: HY-P990733
CAS No.: 2769700-97-0
Synonyms: KER-012

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .
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Cat. No.: HY-P99818
CAS No.: 1169766-01-1
Synonyms: ACE-031

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy .
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Cat. No.: HY-P99720A
CAS No.: 1373715-00-4
Synonyms: RAP-536

Target:  

TGF-beta/Smad

Research Areas:  

Metabolic Disease

Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .
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Cat. No.: HY-RS00249
Research Areas:  

Others

Acvr2b Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acvr2b gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-W1142089
CAS No.: 3039974-32-5
Target:  

TGF-β Receptor

Research Areas:  

Cancer

ActRIIB-IN-2 is an ActRIIB inhibitor with an IC50 of 1.1 nM. ActRIIB-IN-2 can be used for the research of cancer cachexia .
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Cat. No.: HY-183504
CAS No.: 3039974-35-8
Target:  

TGF-β Receptor

Research Areas:  

Cancer

ActRIIB-IN-3 is a ActRIIB inhibitor. ActRIIB-IN-3 inhibits the ActRIIB protein in the MSTN pathway and induces the reversal of skeletal muscle atrophy associated with cancer cachexia. ActRIIB-IN-3 is applicable for the research of cancer cachexia .
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Cat. No.: HY-183005
CAS No.: 3039974-31-4
Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology Cancer

ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC50 of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia .
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Cat. No.: HY-RS00248
Research Areas:  

Others

ACVR2B Human Pre-designed siRNA Set A contains three designed siRNAs for ACVR2B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-W1142093
CAS No.: 3039974-41-6
Target:  

TGF-β Receptor

Research Areas:  

Neurological Disease Cancer

ActRIIB-IN-4 (Compound 10) is an ActRIIB inhibitor with an IC50 of 4.0 nM. ActRIIB-IN-4 enhances muscle grip strength in tumor cachexia mice .
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Cat. No.: HY-P703681
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; Acvr2b; ACTR-IIB
Species:  
Rat
Source:  
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Cat. No.: HY-P704344
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B; ActRIIB; ActR-IIB; HTX4
Species:  
Source:  
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Cat. No.: HY-P700557
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type IIB; ACTR-IIB
Species:  
Source:  
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Cat. No.: HY-P703526
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB
Species:  
Source:  
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Cat. No.: HY-P704048
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; ACTR-IIB; Activin receptor type IIB
Species:  
Source:  
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Cat. No.: HY-P77290
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B
Species:  
Source:  
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Cat. No.: HY-P75536
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B
Species:  
Source:  
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Cat. No.: HY-P72813
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Activin receptor type-2B; Activin receptor type IIB; ACTR-IIB; ACVR2B
Species:  
Source:  
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