country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-183005

Copy Link Print Information

ActRIIB-IN-1

ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC₅₀ of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia.

For research use only. We do not sell to patients.

CAS No.: 3039974-31-4
Formula: C₂₁H₂₂N₆
Molecular Weight:358.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-1 Chemical Structure

CAS No.: 3039974-31-4

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TGF-β Receptor Isoforms :

In Vitro

ActRIIB-IN-1 (Compound 2) (1.25-5 μM; 48 h) alleviates C2C12 mature myotube atrophy induced by C26 cell culture medium^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Viability Assay^[1]

View Protocol

Cell Line:

C2C12 mature myotube
Concentration:

1.25, 2.5, 5 μM
Incubation Time:

48 h
Result:

Showed atrophy reversal rate of 69.2, 97.61 and 130.63%.

In Vivo

ActRIIB-IN-1 (Compound 2) (5 mg/kg; i.g.; qd; 24 days) can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice with C26 tumor cells^[1]
Dosage:

5 mg/kg
Administration:

i.g.; qd; 24 days
Result:

Alleviated weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite.
Did not inhibit tumor growth.

Chemical Information

CAS No. 3039974-31-4
Molecular Weight 358.45
Formula C₂₁H₂₂N₆
SMILES

N=1C=C(C=C2C1NC=C2C3=NNC=C3)C=4C=CC(=CC4)N5CCN(C)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xiaochun Dong, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661. 2025-06-01

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote