2. TGF-beta/Smad
  3. TGF-β Receptor
  4. ActRIIB-IN-1

ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC50 of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia.

For research use only. We do not sell to patients.

ActRIIB-IN-1

ActRIIB-IN-1 Chemical Structure

CAS No. : 3039974-31-4

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ActRIIB-IN-1 Related Antibodies

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Description

ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC50 of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia[1].

In Vitro

ActRIIB-IN-1 (Compound 2) (1.25-5 μM; 48 h) alleviates C2C12 mature myotube atrophy induced by C26 cell culture medium[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ActRIIB-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: C2C12 mature myotube
Concentration: 1.25, 2.5, 5 μM
Incubation Time: 48 h
Result: Showed atrophy reversal rate of 69.2, 97.61 and 130.63%.
In Vivo

ActRIIB-IN-1 (Compound 2) (5 mg/kg; i.g.; qd; 24 days) can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with C26 tumor cells[1]
Dosage: 5 mg/kg
Administration: i.g.; qd; 24 days
Result: Alleviated weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite.
Did not inhibit tumor growth.
Molecular Weight

358.45

Formula

C21H22N6
CAS No.
SMILES

N=1C=C(C=C2C1NC=C2C3=NNC=C3)C=4C=CC(=CC4)N5CCN(C)CC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ActRIIB-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ActRIIB-IN-13039974-31-4TGF-β ReceptorTransforming growth factor beta receptorsskeletal muscle atrophyActRIIBMSTN pathwaycancer cachexiaInhibitorinhibitorinhibit

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