ActRIIB-IN-1
Based on 1 Customer Validation
ActRIIB-IN-1, 7-azaindole compound is an orally active activin type II receptor B (ActRIIB) inhibitor with an IC50 of 1.8 nM. ActRIIB-IN-1 can alleviate weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite. ActRIIB-IN-1 can be used for the research of cancer cachexia.
For research use only. We do not sell to patients.
- Purity : 98.91%
- CAS No.: 3039974-31-4
- Formula: C21H22N6
- Molecular Weight:358.45
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
ActRIIB-IN-1 (Compound 2) (1.25-5 μM; 48 h) alleviates C2C12 mature myotube atrophy induced by C26 cell culture medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:C2C12 mature myotube
-
Concentration:1.25, 2.5, 5 μM
-
Incubation Time:48 h
-
Result:Showed atrophy reversal rate of 69.2, 97.61 and 130.63%.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mice with C26 tumor cells[1]
-
Dosage:5 mg/kg
-
Administration:i.g.; qd; 24 days
-
Result:Alleviated weight loss, muscle atrophy and decreased muscle strength caused by tumor cachexia, as well as improve appetite.
Did not inhibit tumor growth.
Chemical Information
-
CAS No. 3039974-31-4
-
Appearance Solid
-
Molecular Weight 358.45
-
Formula C21H22N6
-
SMILES
N=1C=C(C=C2C1NC=C2C3=NNC=C3)C=4C=CC(=CC4)N5CCN(C)CC5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ActRIIB-IN-1 Related Classifications
HY-183005 Related Classifications
Powered by Bioz