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Results for "

Antileishmanial

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (1) Akt (4) Amino Acid Derivatives (1) Aminoacyl-tRNA Synthetase (1) Antibiotic (2) Apoptosis (12) Autophagy (3) Bacterial (14) Biochemical Assay Reagents (4) Calcium Channel (2) Carbonic Anhydrase (2) Caspase (1) Cholinesterase (ChE) (4) CMV (2) Cytochrome P450 (1) DNA/RNA Synthesis (2) Drug Derivative (1) Drug Intermediate (3) Endogenous Metabolite (3) Environmental Pollutants (5) Fungal (4) Glutathione S-transferase (1) Herbicide (2) HIV (6) HIV Protease (1) HSV (2) iGluR (2) Influenza Virus (2) Interleukin Related (5) Isotope-Labeled Compounds (6) Lactate Dehydrogenase (1) Leukotriene Receptor (2) Microtubule/Tubulin (2) Mitochondrial Metabolism (4) NO Synthase (2) NOD-like Receptor (NLR) (2) Opioid Receptor (1) p38 MAPK (1) Parasite (102) PGE synthase (1) PI3K (1) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Reactive Oxygen Species (ROS) (7) Reference Standards (14) SARS-CoV (1) Succinate Dehydrogenase (1) TGF-beta/Smad (1) TNF Receptor (6) Topoisomerase (2) Tyrosinase (1) UGT (1) Xanthine Oxidase (5)
By Research Areas:	Cancer (23) Cardiovascular Disease (4) Infection (118) Inflammation/Immunology (29) Metabolic Disease (3) Neurological Disease (7)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Phospholipids (1)

124

Inhibitors & Agonists

Peptides

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Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13685

Miltefosine 10+ Cited Publications HePC; Hexadecyl phosphocholine	Akt HIV Parasite	Infection Cancer
Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-16565

10-Deacetylbaccatin III	Biochemical Assay Reagents Drug Intermediate Parasite	Infection
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits *antileishmanial* activity .

HY-147092

Oryzalin 1 Publications Verification	Environmental Pollutants Microtubule/Tubulin Herbicide	Infection
Oryzalin is a dinitroaniline herbicide with antimitotic and antileishmanial activities. Oryzalin can bind to plant tubulin, inhibit the polymerization of microtubules in plant cells, and affect chromosome migration. Oryzalin can also be used to induce chromosome doubling .

HY-W012634

Benzothiazole	Environmental Pollutants Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-N7906

Myricetin 3-O-glucoside 1 Publications Verification Myricetin 3-β-D-glucopyranoside	Bacterial Parasite Antibiotic	Infection Inflammation/Immunology
Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica and Hakmeitau beans. Myricetin 3-O-glucoside exhibits anti-Leishmanial, anti-inflammatory and antimicrobial activities .

HY-W077028

N-(2-Hydroxypropyl)methacrylamide	Biochemical Assay Reagents	Others
N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .

HY-N1453

Hypocrellin B 1 Publications Verification	Apoptosis Fungal Parasite	Infection Cancer
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Cholinesterase (ChE) Endogenous Metabolite Parasite	Infection Neurological Disease Inflammation/Immunology
Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N0397

Harpagide	Parasite	Infection Inflammation/Immunology
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-121368

Mahanine	Parasite	Infection Inflammation/Immunology Cancer
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

HY-W075770

Nickel(II) oxide Nickel monoxide	Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Caspase TGF-beta/Smad p38 MAPK Akt PI3K	Infection Metabolic Disease Cancer
Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide (NiO NPs) exhibits antibacterial, anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species (ROS). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species, activating the TGF-β1-mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors (IL-1β, IL-6) and apoptosis-related molecules (Bax, caspase-3, p53), while inhibiting the activity of the anti-apoptotic molecule Bcl-2. Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis. Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

HY-B0483

Tioxolone	Carbonic Anhydrase Parasite Autophagy Apoptosis	Infection Inflammation/Immunology Cancer
Tioxolone is an inhibitor for the carbonic anhydrase. Tioxolone exhibits anti-leishmanial, antitumor, and anti-inflammatory activities. Tioxolone can be used in research of acne and psoriasis .

HY-W012634S

Benzothiazole-d4	Isotope-Labeled Compounds Bacterial	Cancer
Benzothiazole-d₄ is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-N1077

Vomifoliol	Cholinesterase (ChE) Endogenous Metabolite	Others
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate *antileishmanial* activity .

HY-134467

Phylloflavan	Parasite NO Synthase	Infection
Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC₅₀ of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL) .

HY-151935

Antileishmanial agent-13	Parasite	Infection
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC₅₀s of 0.604 μM and 0.508 μM, respectively .

HY-N7985

Pendulone	Parasite Bacterial	Infection Cancer
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-178784

Antileishmanial agent-37	Parasite	Infection
Antileishmanial agent-37 (Compound 1b) is an *antileishmanial* agent, TbPTR1 (an IC₅₀ value of 17.1 μM) and LmPTR1 inhibitor. Anti-leishmaniasis agent-37 has a moderate effect against Leishmania infantum .

HY-149958

Antileishmanial agent-17	Parasite	Infection
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC₅₀ <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC₅₀ value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

HY-13685R

Miltefosine (Standard) HePC (Standard); Hexadecyl phosphocholine (Standard)	Akt HIV Parasite Reference Standards	Infection Cancer
Miltefosine (Standard) is the analytical standard of Miltefosine. This product is intended for research and analytical applications. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-131300

Colchicoside	Parasite	Infection
Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .

HY-19688B

Sitamaquine tosylate WR 6026 tosylate	Parasite Mitochondrial Metabolism	Infection
Sitamaquine (WR6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine tosylate inhibits mitochondrial complex II (succinate dehydrogenase). Sitamaquine tosylate is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .

HY-N8471

Niazinin	Parasite SARS-CoV	Infection Inflammation/Immunology
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-162498

Antileishmanial agent-29	Parasite	Infection
Antileishmanial agent-29 (Compound 110) is an orally active antileishmanial agent. Antileishmanial agent-29 (p.o., 40, 60 mg/kg, 10 days) protects mice from leishmania infection .

HY-W097659

Antileishmanial agent-32	Parasite	Infection
Antileishmanial agent-32 (Compound 12) exhibits a weak antileishmanial activity that inhibits stationary promastigote forms of L. amazonensis with an IC₅₀ >15 μM. Antileishmanial agent-32 exhibits cytotoxicity towards murine macrophages .

HY-155301

Antileishmanial agent-24	Parasite	Infection
Antileishmanial agent-24 (compound 33) is an antileishmanial agent with an IC₅₀ of 5.39 μM against amastigote .

HY-W631668

Antileishmanial agent-34	Parasite	Infection
Antileishmanial agent-34 (Fig. (9), compound 3) is an aurone with antileishmanial activity. Antileishmanial agent-34 against extracellular forms of Lmaj, Ldon, Linf and Lenr as well as against intracellular forms of Ldon (IC₅₀ of <2 µg/mL) .

HY-138812

Antileishmanial agent-28	Parasite	Infection Inflammation/Immunology
Antileishmanial agent-28 (Compd 12) is an antileishmanial agent, with EC₅₀ values of 1.5 μM (L.donovani), 13 μM (L.amazonensis) and 18 μM (J774A.1), respectively .

HY-156427

Antileishmanial agent-25	Parasite	Infection
Antileishmanial agent-25 (compound 24) is selective *antileishmanial* activity on intracellular amastigotes, with the IC₅₀ of 6.63 μM .

HY-155549

Antileishmanial agent-20	Parasite	Infection
Antileishmanial agent-20 is selective towards Leishmania parasite. Antileishmanial agent-20 has IC₅₀ value of 2.8 μM and 0.2 μM for L. infantum and L. braziliensis, respectively. Antileishmanial agent-20 can be used for parasites research .

HY-149834

Antileishmanial agent-18	Parasite	Infection
Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells .

HY-149956

Antileishmanial agent-15	Parasite	Infection
Antileishmanial agent-15 (compound 13c) is a potent antileishmanial agent. Antileishmanial agent-15 shows antileishmanial and cytotoxic activity against L. major promastigotes and amastigotes, with IC₅₀ values of 0.78 and 0.99 μM, respectively .

HY-146744

Antileishmanial agent-4	Parasite	Infection
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent .

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-146745

Antileishmanial agent-5	Parasite	Inflammation/Immunology
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC₅₀ values of 0.68 μM and 0.83 μM, respectively .

HY-147535

Antileishmanial agent-7	Parasite	Infection
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively .

HY-147534

Antileishmanial agent-6	Parasite	Infection
Antileishmanial agent-6 (compound 8m) is a potent antileishmanial agent. Antileishmanial agent-6 shows antileishmanial and cytotoxic activity against Leishmania donovani and L-6, with IC₅₀ values of 0.54 and 10.2 μM, respectively .

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-N6816

Ludaconitine	Parasite	Infection
Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL .

HY-127160

Benzoxonium chloride	Environmental Pollutants Bacterial Parasite	Infection
Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .

HY-178033

Antileishmanial agent-35	Parasite Mitochondrial Metabolism Reactive Oxygen Species (ROS)	Infection
Antileishmanial agent-35 (Compound 6) is an antileishmanial agent with an IC₅₀ of 0.29μM for promastigotes of Leishmania amazonensis. Antileishmanial agent-35 significantly decreases the mitochondrial membrane potential and ATP levels, and further increases the production of ROS by a blockage in the electron transport chain, where ubiquinone intervenes. Antileishmanial agent-35 can be used for cutaneous leishmaniases research .

HY-B0221A

Amphotericin B trihydrate	Antibiotic Fungal Bacterial Parasite	Infection Inflammation/Immunology Cancer
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .

HY-N15413

Thalidasine	Parasite	Infection
Thalidasine (compound 3) is a bisbenzyltetrahydroisoquinoline alkaloid. Thalidasine is a anticancer agent against human colon adenocarcinoma cells. Thalidasine exhibits antileishmanial activity and can be used for Leishmania infection research research .

HY-125648

Euphorbadienol alpha-Euphorbol	Parasite	Infection
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-N2926

β-Carboline-1-propionic acid	Parasite	Infection
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .

HY-B0219S

Allopurinol-d2	Isotope-Labeled Compounds Xanthine Oxidase	Infection Inflammation/Immunology
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC₅₀ values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect .

Cat. No.	Product Name	Target	Research Area

HY-P2310

Defensin HNP-1 human	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human has antileishmanial activity. Defensin HNP-1 human is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite Apoptosis HIV HSV CMV TNF Receptor Interleukin Related NOD-like Receptor (NLR) DNA/RNA Synthesis Influenza Virus	Cardiovascular Disease Infection
Defensin HNP-1 human TFA is a type of human neutrophil peptide (HNPs). Defensin HNP-1 human TFA possesses immunomodulatory functions and can delay the apoptosis of neutrophils. Defensin HNP-1 human TFA inhibits DNA/RNA/protein synthesis and interferes with metabolic pathways, thus exhibiting broad antibacterial activity. Defensin HNP-1 human TFA has direct inactivation effects on HIV, HSV-1, HSV-2, CMV, influenza virus, etc. Defensin HNP-1 human TFA has antileishmanial activity. Defensin HNP-1 human TFA is involved in endothelial cell dysfunction during the early development of atherosclerosis .

HY-P1957

Dihydrocyclosporin A	Parasite	Infection
Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16565

10-Deacetylbaccatin III	Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Source Classification Cancer	Biochemical Assay Reagents Drug Intermediate Parasite
10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata). 10-Deacetylbaccatin III exhibits *antileishmanial* activity .

HY-W012634

Benzothiazole	Source Classification	Environmental Pollutants Bacterial
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-N7906

Myricetin 3-O-glucoside 1 Publications Verification Myricetin 3-β-D-glucopyranoside	Flavonoids Microorganisms Leguminosae Clitoria ternatea Linn. Plants Isoflavones Source Classification	Bacterial Parasite Antibiotic
Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica and Hakmeitau beans. Myricetin 3-O-glucoside exhibits anti-Leishmanial, anti-inflammatory and antimicrobial activities .

HY-76228

1H-pyrazole Pyrazole	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Parasite iGluR
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-N1453

Hypocrellin B 1 Publications Verification	Infection Microorganisms other families Classification of Application Fields Phenols Polyphenols Pigments Plants Disease Research Fields Source Classification Food Research	Apoptosis Fungal Parasite
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Natural Products Verbenaceae Plants Endogenous metabolite Lantana camaraLinn. Source Classification	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N0397

Harpagide	Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Parasite
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-121368

Mahanine	Infection Alkaloids Monophenols Classification of Application Fields Rutaceae Murraya koenigii (L.) Spreng Phenols Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Parasite
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

HY-N7926

Pentadecane	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Environmental Pollutants Apoptosis Parasite TNF Receptor Interleukin Related
Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-N1077

Vomifoliol	Natural Products Classification of Application Fields Plants Endogenous metabolite Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Other Diseases Abscisic acid Phytohormone Disease Research Fields Source Classification	Cholinesterase (ChE) Endogenous Metabolite
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate *antileishmanial* activity .

HY-134467

Phylloflavan	Structural Classification other families Phyllocladus alpinus Phenols Polyphenols Plants Source Classification	Parasite NO Synthase
Phylloflavan is an antileishmanial (Antileishmanial) agent with an EC₅₀ of 3.2 nM against intracellular amastigotes of Leishmania donovani. Phylloflavan is isolated from Phyllocldus plants. Phylloflavan induces moderate levels of NO release. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblasts (38 U/mL) .

HY-W015818

2-Benzoxazolinone 1 Publications Verification 2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole	Infection Alkaloids Classification of Application Fields Other Alkaloids Gramineae Secale cereale Plants Disease Research Fields Source Classification	Parasite
2-Benzoxazolinone is an *anti-leishmanial* agent with an LC₅₀ of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of IL-10, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N7985

Pendulone	Infection Quinones Monophenols other families Classification of Application Fields Phenols Benzene Quinones Plants Disease Research Fields Source Classification	Parasite Bacterial
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-W019829

Polyphyllin C	Infection other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	Tyrosinase Parasite
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-131300

Colchicoside	Colchicaceae Gloriosa superbaL. Plants Source Classification	Parasite
Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .

HY-N8471

Niazinin	Natural Products Classification of Application Fields Moringa oleifera Lam. Moringaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Parasite SARS-CoV
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-N6816

Ludaconitine	Infection Classification of Application Fields Terpenoids Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields Source Classification	Parasite
Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL .

HY-B0221A

Amphotericin B trihydrate	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Inflammation/Immunology Disease Research Fields Source Classification	Antibiotic Fungal Bacterial Parasite
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .

HY-N15413

Thalidasine	Alkaloids Ranunculaceae Quinoline Alkaloids Thalictrum alpinum L. Plants Source Classification	Parasite
Thalidasine (compound 3) is a bisbenzyltetrahydroisoquinoline alkaloid. Thalidasine is a anticancer agent against human colon adenocarcinoma cells. Thalidasine exhibits antileishmanial activity and can be used for Leishmania infection research research .

HY-125648

Euphorbadienol alpha-Euphorbol	Infection Classification of Application Fields Ketones, Aldehydes, Acids Euphorbia wallichii Euphorbiaceae Plants Disease Research Fields Source Classification	Parasite
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-N2926

β-Carboline-1-propionic acid	Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Pyrrole Alkaloids Plants Source Classification	Parasite
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .

HY-N7489

β-Hederin	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae Source Classification	Parasite
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses *antileishmanial* activity. β-Hederin exhibits IC₅₀ values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Phenols Polyphenols Hypoxis angustifolia Lam. Plants Source Classification Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, *antileishmanial, hyaluronidase* inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-W012634R

Benzothiazole (Standard)	Microorganisms Source Classification	Reference Standards Bacterial
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .

HY-N1453R

Hypocrellin B (Standard)	Microorganisms other families Phenols Polyphenols Plants Source Classification	Reference Standards Apoptosis Fungal Parasite
Hypocrellin B (Standard) is the analytical standard of Hypocrellin B. This product is intended for research and analytical applications. Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].

HY-75247R

Coumaran (Standard) 2,3-Dihydrobenzofuran (Standard)	Structural Classification Natural Products Verbenaceae Plants Endogenous metabolite Lantana camaraLinn. Source Classification	Cholinesterase (ChE) Endogenous Metabolite Parasite Reference Standards
Coumaran (Standard) is the analytical standard of Coumaran. This product is intended for research and analytical applications. Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N8181

1,3-Linolein-2-Olein	Infection Structural Classification Classification of Application Fields Campanulaceae Plants Codonopsis thalictrifoliaWall. Disease Research Fields Lipid Source Classification	Parasite
1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC₅₀=0.079 ug/ml) and inhibits the growth of amastigotes (IC₅₀= 40.03 ug/ml) .

HY-N16426

Mycoleptone A	Natural Products Microorganisms Source Classification	Parasite
Mycoleptone A is an azafluorenone compound. Mycoleptone A exhibits certain anti-leishmanial activity, with an LD₅₀ of 28.5 μM against L. major. Mycoleptone A shows cytotoxicity against human prostate cancer cell line PC3, with an IC₅₀ of 10.0 μM. Mycoleptone A can be used in research on anti-parasitic and anti-tumor aspects .

HY-N0397R

Harpagide (Standard)	Iridoids Scrophularia ningpoensis Hemsl. Terpenoids Scrophulariaceae Plants Source Classification	Reference Standards Parasite
Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC₅₀ of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-N2894

Piperolactam A	Alkaloids Piper betle L. Piperaceae Plants Source Classification	Parasite
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

HY-W015818R

2-Benzoxazolinone (Standard) 2-Benzoxazolone (Standard); 1,3-Benzoxazol-2(3H)-one (Standard); 2-Hydroxybenzoxazole (Standard)	Alkaloids Structural Classification Other Alkaloids Gramineae Secale cereale Plants Source Classification	Reference Standards Parasite
2-Benzoxazolinone (Standard) is the analytical standard of 2-Benzoxazolinone. This product is intended for research and analytical applications. 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent[4].

HY-76228R

1H-pyrazole (Standard) Pyrazole (Standard)	Alkaloids Structural Classification Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Parasite iGluR
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-N7926R

Pentadecane (Standard)	Structural Classification Natural Products Kaempferia galanga L. Plants Source Classification Zingiberaceae	Parasite Reference Standards TNF Receptor Interleukin Related Apoptosis
Pentadecane (Standard) is the analytical standard of Pentadecane (HY-N7926). This product is intended for research and analytical applications. Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

HY-N19720

Bractein	Structural Classification Crotalaria albida Heyne ex Roth Phenols Polyphenols Plants Compositae Source Classification	Drug Derivative Parasite
Bractein is a natural aurone flavonoid with potential antioxidant activity. Bractein shows in vitro *antileishmanial* activity and inhibits promastigotes and intracellular amastigotes of Leishmania donovani. Bractein exhibits no obvious cytotoxicity against mammalian macrophages with an EC₅₀ value > 25.0 μg/mL. Bractein can be used for the research of Leishmania .

HY-N16745

5-Hydroxynoracronycine	Structural Classification Alkaloids Citrus hystrix DC. Rutaceae Acridone Alkaloids Plants Source Classification	Parasite HIV HIV Protease
5-Hydroxynoracronycine is a selective inhibitor targeting Leishmania, HIV-1 protease, and nitric oxide (NO) production. 5-Hydroxynoracronycine has an IC₅₀ of 93.1 μmol/L against HIV-1 protease and an IC₅₀ of 0.19 mg/mL for scavenging DPPH free radicals. 5-Hydroxynoracronycine exerts anti-leishmanial, anti-HIV, antioxidant and antibacterial activities by inhibiting pathogen proliferation, enzyme activity and inflammation-related NO excessive production. 5-Hydroxynoracronycine can be used in the research of leishmaniasis, HIV infection, and inflammation-related diseases .

HY-N17550

25-Hydroperoxycycloart-23-en-3β-ol	Triterpenes Structural Classification Terpenoids Euphorbia esula L. Euphorbiaceae Plants Source Classification	Bacterial Parasite
25-Hydroperoxycycloart-23-en-3β-ol is an anticancer, antibacterial, and antimalarial agent. 25-Hydroperoxycycloart-23-en-3β-ol can be isolated from Blepharodon nitidum. 25-Hydroperoxycycloart-23-en-3β-ol exhibits anti-*Mycobacterium* *tuberculosis* and *antileishmanial* activities. 25-Hydroperoxycycloart-23-en-3β-ol shows significant cytotoxic activity against a panel of tumor cell lines (large cell lung cancer, melanoma, colon adenocarcinoma, chronic myelogenous leukemia) .

Cat. No.	Product Name	Chemical Structure

HY-W012634S

Benzothiazole-d4
Benzothiazole-d₄ is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

HY-B0219S1

Allopurinol-13C,15N2

Allopurinol- ¹³C, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled labeled Allopurinol (HY-B0219). Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC₅₀ value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect .

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC₅₀ values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect .

HY-W779244

1H-Pyrazole-3,4,5-d3
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-13685S1

Miltefosine-d4
Miltefosine-d₄ (HePC-d₄) is deuterium labeled Miltefosine. Miltefosine is a broad spectrum antimicrobial, anti-leishmanial, phospholipid agent acting by inhibiting the PI3K/Akt activity . Miltefosine is an inhibitor of CTP-phosphocholine cytidyltransferase (CCT) .

HY-N7926S

Pentadecane-d32

Pentadecane-d₃₂ is the deuterium labeled Pentadecane (HY-N7926). Pentadecane is an orally active natural plant volatile alkane with anti-inflammatory, analgesic, antipyretic and anti-leishmanial activities. Pentadecane presents IC₅₀ values of 65.3 μM, 60.5 μM and 194.8 μM against Leishmania infantum promastigotes, amastigotes and intracellular amastigotes, respectively. Pentadecane downregulates the mRNA expression of TNF-α and IL-12 and inhibits the release of inflammatory mediators. Pentadecane arrests the cell cycle of Leishmania infantum and induces apoptosis. Pentadecane can be applied to the research of inflammation and leishmaniasis .

Cat. No.	Product Name		Classification

HY-168262

Antitrypanosomal agent 22		Alkynes
Antitrypanosomal agent 22 (compound 13) is a nitrothienylazine compound with trypanosomaticidal efficacy. Antitrypanosomal agent 22 shows leishmanicidal and trypanocidal with in vitro submicromolar activities, and devoid of toxicity on mammalian cells are uncovered .

Cat. No.	Product Name		Classification