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Antitubercular

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (11) Apoptosis (2) Autophagy (4) Bacterial (105) Biochemical Assay Reagents (1) Carboxylesterase (CES) (2) DNA/RNA Synthesis (4) Drug Derivative (1) Drug Intermediate (1) Fungal (10) Isotope-Labeled Compounds (3) MDM-2/p53 (1) Parasite (6) Reference Standards (7) Virus Protease (1)
By Research Areas:	Cancer (10) Endocrinology (2) Infection (104) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

110

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0804

Narirutin 5 Publications Verification	Bacterial	Inflammation/Immunology
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-B0271

Pyrazinamide 4 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-14989

SQ109 4 Publications Verification NSC 722041	Parasite Bacterial Antibiotic	Infection
SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC₅₀ for cell killing of 50±8 nM. SQ109, targets MmpL3, is an antitubercular agent.

HY-B1526

Thiacetazone Thioacetazone; Amithiozone	Bacterial Antibiotic	Infection
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of *Mycobacterium tuberculosis H37Rv* with a MIC value of 0.1 μg/mL .

HY-107775

Ganfeborole hydrochloride 5 Publications Verification GSK656; GSK3036656; GSK070	Bacterial	Infection
Ganfeborole hydrochloride (GSK656) is a potent antitubercular agent, acting as an inhibitor of *Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC₅₀* of 0.2 μM.

HY-19750

TBA-7371 1 Publications Verification	Bacterial	Infection
TBA-7371 is an orally active and non-covalent inhibitor of Decaprenylphosphoryl-β-D-ribose oxidase (DprE1) of Mycobacterium tuberculosis (MIC=0.64 μg/mL). TBA-7371 can block the synthesis of arabinose in the bacterial cell wall, resulting in cell wall structural defects, thereby exerting an anti-tuberculosis effect. TBA-7371 can be used in the research of anti-tuberculosis drugs and has a synergistic bactericidal effect with Bedaquiline (HY-14881) and other drugs .

HY-147017

GSK2556286 GSK286	Bacterial	Infection Inflammation/Immunology
GSK2556286 (GSK286) is an orally active and cholesterol-dependent *Mycobacterium tuberculosis* inhibitor. GSK2556286 inhibits *Mycobacterium tuberculosis* inside infected macrophages (IC₅₀ = 0.07 μM in THP-1 cells), in the presence of cholesterol. GSK2556286 acts via Rv1625c, a membrane-bound adenylyl cyclase in *Mycobacterium tuberculosis. GSK2556286 is an Rv1625* agonist leading to increased cAMP and reduced cholesterol metabolism. GSK2556286 can be studied in research for antitubercular purposes .

HY-N9596

Stigmasta-4,22-dien-3-one	Bacterial	Infection Cancer
Stigmasta-4,22-dien-3-one is an *antitubercular* agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC₅₀ of 0.3 mM .

HY-160922

BAY 249716	MDM-2/p53 Bacterial	Infection Cancer
BAY 249716 stabilizes all three p53 protein variants. BAY 249716 also has antitubercular activity (IC₉₀: <0.10 μg/mL for Tuberculosis) .

HY-B0271R

Pyrazinamide (Standard) Pyrazinecarboxamide (Standard); Pyrazinoic acid amide (Standard)	Reference Standards Bacterial Autophagy Antibiotic	Infection
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-B0271S

Pyrazinamide-d3 Pyrazinecarboxamide-d₃; Pyrazinoic acid amide-d₃	Isotope-Labeled Compounds Bacterial Autophagy Antibiotic	Infection
Pyrazinamide-d₃ is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis .

HY-132910

Antitubercular agent-9	Bacterial	Infection
Antitubercular agent-9 shows effective antitubercular activity with a MIC value of 1.03-2.32 μM.

HY-146120

Antitubercular agent-25	Bacterial	Infection
Antitubercular agent-25 (Compound 28) is an anti-tubercular agent with an extracellular IC₅₀ of 0.42 μM and an intracellular IC₅₀ of 0.20 μM against M. tuberculosis H37Rv. Antitubercular agent-25 exhibits good metabolic stability .

HY-124781

ML406	Bacterial Antibiotic	Infection
ML406 is a small molecule probe that shows *anti-tubercular* activity via M.tuberculosis BioA (DAPA synthase) enzyme inhibition with an IC₅₀ of 30 nM. M.tuberculosis BioA is an enzyme involved in biotin biosynthesis in M.tuberculosis .

HY-W716669

Morinamide	Bacterial Drug Derivative	Infection
Morinamide is an antibacterial agent, antitubercular agent and Pyrazine (HY-W013040) derivative. Morinamide can be used in the research of tuberculosis .

HY-B0271S1

Pyrazinamide-13C,15N Pyrazinecarboxamide-¹³C,¹⁵N; Pyrazinoic acid amide-¹³C,¹⁵N	Autophagy Antibiotic Bacterial Isotope-Labeled Compounds	Infection
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-151960

Antitubercular agent-36	Bacterial	Infection
Antitubercular agent-36 (compound 53) is an antitubercular agent. Antitubercular agent-36 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL. Antitubercular agent-36 can be used for the research of tuberculosis .

HY-178802

Antitubercular agent-53	Bacterial	Infection
Antitubercular agent-53 (Compound 5b) is an *antitubercular* agent and antibacterial agent. Antitubercular agent-53 shows antitubercular activity against M. tuberculosis H37RV with an MIC of 4 μg/mL .

HY-126640

Phomoxanthone A	Parasite	Infection Cancer
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-163437

Antitubercular agent-45	Bacterial Fungal	Infection
Antitubercular agent-45 (Compound 5g) is an antifungal and antitubercular agent. Antitubercular agent-45 inhibits S. aureus, MRSA, B. subtilis, E. coli, C. albicans with MIC values of 6.4, 10.8, 6.1, 8.4 , 8.1 μM respectively .

HY-144722

Antitubercular agent-12	Bacterial	Infection
Antitubercular agent-12 (Compound 2c) is an antitubercular agent (MIC = 1.439 μg/mL). Antitubercular agent-12 shows greatly lower cytotoxicity (CC50: 57.34 μg/mL) .

HY-151958

Antitubercular agent-35	Bacterial	Infection
Antitubercular agent-35 (compound 42l) is an antitubercular agent. Antitubercular agent-35 inhibits the growth of Mtb_H37Rv and *M. Marinum* with MIC₉₀ values of 1.25 and 2 μg/mL, respectively. Antitubercular agent-35 shows the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent-35 can be used for the research of tuberculosis .

HY-176246

Antitubercular agent-52	Bacterial	Infection
Antitubercular agent-52 (Compound 7k) is an antitubercular agent targeting Mycobacterium tuberculosis (Mtb). Antitubercular agent-52 selectively inhibits the cytochrome bcc (cyt-bcc) electron transport chain of Mtb and also acts on cytochrome bd (cyt-bd). Antitubercular agent-52 blocks electron transfer and ATP production by interfering with the key energy metabolism pathway of Mtb. Antitubercular agent-52 is promising for research of tuberculosis .

HY-146107

Antitubercular agent-23	Bacterial Fungal	Infection
Antitubercular agent-23 (Compound 3a) is a potent anticandidiasis and antitubercular agent with MIC values of 1.1 µg/ml and 1 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-146106

Antitubercular agent-22	Bacterial Fungal	Infection
Antitubercular agent-22 (Compound 2) is a potent anticandidiasis and antitubercular agent with MIC values of 2.34 µg/ml and 2 µg/ml against Candida albicans MTCC 3017 and M. tuberculosis (H37Rv), respectively .

HY-151339

Antitubercular agent-31	Bacterial	Infection
Antitubercular agent-31 (Compound 2) is an antitubercular agent with an MIC of 0.03 μM against M. tuberculosis H37Rv. Antitubercular agent-31 also inhibits DprE1 with an IC₅₀ of 1.1 μM .

HY-151957

Antitubercular agent 34	Bacterial	Infection
Antitubercular agent 34 (compound 42g) is an antitubercular agent. Antitubercular agent 34 inhibits the growth of Mtb_H37Rv with a MIC₉₀ value of 1.25 μg/mL with the ability of escaping metabolic degradation by human liver microsomes. Antitubercular agent 34 can be used for the research of tuberculosis .

HY-155190

Antitubercular agent-39	Bacterial	Infection
Antitubercular agent-39 (Compound P1) is a potent antitubercular agent. Antitubercular agent-39 is active against drug-resistant strains and drug-susceptible clinical isolates. Antitubercular agent-39 inhibits Mtb strain H37Rv with a MIC less than 1 μM .

HY-144723

Antitubercular agent-13	Bacterial	Infection
Antitubercular agent-13 (Compound 3d) is an antitubercular agent with MIC values of 0.007 µg/mL and 1.851 µg/mL against MTB H37Rv and MDR-MTB 16833, respectively. Antitubercular agent-13 shows metabolic instability .

HY-129943

Benzothiohydrazide	Bacterial	Infection
Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC₁ and IC₂) .

HY-146051

Antitubercular agent-18	Bacterial	Infection
Antitubercular agent-18 (Compound 9a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-18 shows highly selective antimycobacterial effects .

HY-146050

Antitubercular agent-17	Bacterial	Infection
Antitubercular agent-17 (Compound 8a) is an antitubercular agent with MIC values of 2, 2, 2 and 128 µg/ml against M. tuberculosis H37Rv, Spec. 192, Spec 210 and Spec. 800, respectively. Antitubercular agent-17 shows highly selective antimycobacterial effects .

HY-163069

Antitubercular agent-43	Bacterial	Infection
Antitubercular agent-43 (compound A11) is an orally active and potent antitubercular agent. Antitubercular agent-43 shows highly metabolic stability against human and mouse cytochrome P450 enzymes. Antitubercular agent-43 exhibits bactericidal efficacy in acute TB infection mouse model .

HY-120555

Texaline	Bacterial	Infection
Texaline is a active product that can be isolated from Amyris species of plants in the Caribbean. Texaline has antitubercular activity .

HY-139424

SQ609	Bacterial	Cancer
SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .

HY-151340

Antitubercular agent-32	Bacterial	Infection
Antitubercular agent-32 is a derivate of Benzothiazinone (HY-13579A), inhibits M. tuberculosis, and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase (DprE1, IC₅₀=3.9 μM) .

HY-W002297

(S)-3-Aminoazepan-2-one	Biochemical Assay Reagents	Infection
(S)-3-Aminoazepan-2-one is the structural unit of the antitubercular peptide, serving as the core scaffold of a hexapeptide antibacterial agent. (S)-3-Aminoazepan-2-one is promising for research of tuberculosis .

HY-N0804R

Narirutin (Standard)	Reference Standards Bacterial	Inflammation/Immunology
Narirutin (Standard) is the analytical standard of Narirutin. This product is intended for research and analytical applications. Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-W012813

2-Acetyl-5-methylfuran	Bacterial	Infection
2-Acetyl-5-methylfuran is a growth inhibitor of Mycobacterium tuberculosis, exhibiting an in vitro anti-tubercular activity with an MIC of 322.58 μM. 2-Acetyl-5-methylfuran demonstrates high safety and can be used for research related to tuberculosis .

HY-152138

Antituberculosis agent-8	Bacterial Fungal	Infection
Antituberculosis agent-8 (Compound 9i) is an antitubercular agent with an MIC of 3.53 μM (1.6 μg/mL) against *M. tuberculosis H37Rv. Antituberculosis agent-8 also shows good antifungal* activity against A. niger with an MIC of 62.50 μM .

HY-32806

2-Chloro-4-methyl-3-nitropyridine	Drug Intermediate	Infection
2-Chloro-4-methyl-3-nitropyridine is a pyridine derivative that can be used to synthesize 2-methoxypyridine derivatives with antibacterial and antituberculosis activities .

HY-148111

Antitubercular agent-33	Bacterial	Infection
Antitubercular agent-33 is a 2-aminothiazole derivative, shows potent antintubercular activity against Mycobacterium tuberculosis (Mtb) .

HY-162684

Antitubercular agent-46	Bacterial	Infection Inflammation/Immunology
Antitubercular agent-46 (4B) is an anti-tubercular agent, with a MIC of 7.81 μg/ mL. Antitubercular agent-46 (4B) possesses antioxidant activity .

HY-132928

Antitubercular agent-10	Bacterial	Infection
Antitubercular agent-10 shows potent antitubercular activity with a MIC value of 30 nM.

HY-144721

Antitubercular agent-11	Bacterial	Infection
Antitubercular agent-11 (Compound 1e) is an antitubercular agent. Antitubercular agent-11 with a bulkier electron-donating group (Bu-t) demonstrated the best MIC value of 0.060 μg/mL .

HY-149857

Antitubercular agent-37	Bacterial	Infection
Antitubercular agent-37 is an antibacterial agent. Antitubercular agent-37 has antimycobacterial activity with an MIC values of 0.16 μg/mL. Antitubercular agent-37 can be used for the research of tuberculosis .

HY-146496

Antitubercular agent-20	Bacterial	Infection
Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .

HY-147505

Antitubercular agent-21	Bacterial Fungal	Infection
Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H₃₇R_v. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .

HY-146495

Antitubercular agent-19	Bacterial	Infection
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .

HY-156022

Antitubercular agent-41	Bacterial	Neurological Disease
Antitubercular agent-41 (Compound 106) is an antitubercular agent that can be used in the study of Mycobacterium tuberculosis infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0804

Narirutin 5 Publications Verification	Flavonoids Classification of Application Fields Flavonones Rutaceae Phenols Polyphenols Plants Citrus Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-B0271

Pyrazinamide 4 Publications Verification Pyrazinecarboxamide; Pyrazinoic acid amide	Source Classification	Bacterial Autophagy Antibiotic
Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-N1377

Nevadensin Lysionotin	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields Source Classification	Carboxylesterase (CES) DNA/RNA Synthesis Apoptosis Bacterial
Nevadensin (Lysionotin), a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC₅₀ of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC₅₀ of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities .

HY-N9596

Stigmasta-4,22-dien-3-one	Leguminosae Plants Steroids Source Classification Erythrina variegata Linn.	Bacterial
Stigmasta-4,22-dien-3-one is an *antitubercular* agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC₅₀ of 0.3 mM .

HY-B0271R

Pyrazinamide (Standard) Pyrazinecarboxamide (Standard); Pyrazinoic acid amide (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Autophagy Antibiotic
Pyrazinamide (Standard) is the analytical standard of Pyrazinamide. This product is intended for research and analytical applications. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-126640

Phomoxanthone A	Quinones Microorganisms Anthraquinones Source Classification	Parasite
Phomoxanthone A is a xanthone dimer, which can be isolated from Phomopsis. Phomoxanthone A exhibits antimalarial and antitubercular activities against Plasmodium falciparum (K1, multidrug-resistant strain, IC₅₀ is 0.11 µg/mL) and Mycobacterium tuberculosis (H37Ra strain, MIC is 0.50 µg/mL). Phomoxanthone A exhibits cytotoxicity in cells KB, BC-1 and Vero, IC₅₀ is 0.99, 0.51 and 1.4 µg/mL, respectively .

HY-N0804R

Narirutin (Standard)	Structural Classification Flavonoids Flavonones Rutaceae Phenols Polyphenols Plants Citrus Source Classification	Reference Standards Bacterial
Narirutin (Standard) is the analytical standard of Narirutin. This product is intended for research and analytical applications. Narirutin, one of the active constituents isolated from citrus fruits, has antioxidant and anti-inflammatory activities. Narirutin is a shikimate kinase inhibitor with anti-tubercular potency .

HY-W012813

2-Acetyl-5-methylfuran	Cinnamomum kotoense Kaneh. & Sasaki Structural Classification Ketones, Aldehydes, Acids Plants Lauraceae Source Classification	Bacterial
2-Acetyl-5-methylfuran is a growth inhibitor of Mycobacterium tuberculosis, exhibiting an in vitro anti-tubercular activity with an MIC of 322.58 μM. 2-Acetyl-5-methylfuran demonstrates high safety and can be used for research related to tuberculosis .

HY-N12276

(±)-Emodin bianthrone	Microorganisms Phenols Polyphenols Source Classification	Parasite Bacterial Fungal
(±)-Emodin bianthrone (compound 10), a natural product, exhibits antimalarial, antitubercular and ntifungal activities .

HY-124301

Penicolinate A	Infection Alkaloids Microorganisms Classification of Application Fields Pyridine Alkaloids Disease Research Fields Source Classification	Bacterial
Penicolinate A is a picolinic acid derivative. Penicolinate A is isolated from endophytic Penicillium sp. BCC16054. Penicolinate A exhibits antimalarial and antitubercular activities .

HY-N3661

(24S)-Cycloartane-3β,24,25-triol	Triterpenes Terpenoids Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Source Classification	Bacterial
(24S)-Cycloartane-3β,24,25-triol, a cycloartane, has antitubercular activity against Mycobacterium tuberculosis H37Rv (MIC: 32 μg/mL). (24S)-Cycloartane-3β,24,25-triol can be isolated from the flowers of Chrysanthemum morifolium .

HY-N10992

Pomolic acid 3-acetate	Triterpenes Terpenoids Rosaceae Plants Source Classification Acaena pinnatifida Ruiz & Pav.	Bacterial
Pomolic acid 3-acetate is an *antitubercular* agent with a MIC of 32 μM against Mycobacterium tuberculosis H₃₇Rv .

HY-N8388

Collinin	Zanthoxylum schinifolium Sieb. et Zucc. Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial
Collinin is a anti-tubercular agent, it can be isolated from leaves of Z. schinifolium. Collinin has an excellent anti-tuberculosis effect against multidrug-resistant (MDR), extensively drug-resistant (XDR) strains .

HY-N12230

Penicolinate B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Bacterial Parasite Fungal
Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC₅₀: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC₅₀: 25.0 μg/mL), and activity against Candida albicans (IC₅₀: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors .

HY-N1377R

Nevadensin (Standard) Lysionotin (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Carboxylesterase (CES) Reference Standards DNA/RNA Synthesis Apoptosis Bacterial
Nevadensin (Standard) (Lysionotin (Standard)) is the analytical standard of Nevadensin (HY-N1377). This product is intended for research and analytical applications. Nevadensin, a natural flavonoid, is a selective human carboxylesterase 1 (hCE1) inhibitor with an IC₅₀ of 2.64 μM. Nevadensin is more selective for hCE1 than hCE2 (IC₅₀ of 132.8 μM). Nevadensin can induce apoptosis and DNA damage in cancer cells. Nevadensin has a variety of pharmacological effects such as anti-inflammatory, anti-tumour, anti-hypertensive, anti-tubercular, antitussive, antioxidant and anti-microbial activities.

HY-N11650

(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid	Triterpenes Microorganisms Terpenoids Source Classification	Bacterial
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) is an antitubercular agent with MIC value of 12.5 μg/mL for Mycobacterium tuberculosis H37Ra. (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid shows cytotoxicity with IC₅₀ value of 32 μM for Vero cells .

HY-N13011

Maniladiol	Triterpenes Structural Classification Terpenoids Plants Compositae Baccharis sarothroides A.Gray Source Classification	Bacterial
Maniladiol is a triterpenoid that can be isolated from the flowers of Chrysanthemum morifolium. Maniladiol exhibits antitubercular activity against Mycobacterium tuberculosis strain H37Rv with a MIC of 4 mg/mL. Maniladiol can be used for Mycobacterium tuberculosis infection research .

Cat. No.	Product Name	Chemical Structure

HY-B0271S

Pyrazinamide-d3
Pyrazinamide-d₃ is deuterium labeled Pyrazinamide. Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis .

HY-B0271S1

Pyrazinamide-13C,15N
Pyrazinamide- ¹³C, ¹⁵N is ¹⁵N and ¹³C labeled Pyrazinamide (HY-B0271). Pyrazinamide (Pyrazinecarboxamide; Pyrazinoic acid amide) is a potent and orally active antitubercular antibiotic. Pyrazinamide is a proagent that is converted to the active form pyrazinoic acid (POA) by PZase/nicotinamidase encoded by the pncA gene in M. tuberculosis.

HY-N9596S

Stigmasta-4,22-dien-3-one-d5
Stigmasta-4,22-dien-3-one-d₅ is the deuterium labeled Stigmasta-4,22-dien-3-one (HY-N9596). Stigmasta-4,22-dien-3-one is an antitubercular agent. Stigmasta-4,22-dien-3-one shows cytotoxicity against human HT1080 tumoral cell line with an IC₅₀ of 0.3 mM .

Cat. No.	Product Name		Classification

HY-W326159

Giparmen		Alkynes
Giparmen is an anti-tubercular agent. Giparmen is promising for research of fungal infections, particularly Candida .

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