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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
Aquaporins
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "Aquaporins" in MCE Product Catalog:
25
25 Publications Verification
Cat. No.: HY-W008574
CAS No.: 51987-99-6
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TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .
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25 Publications Verification
Cat. No.: HY-W008574A
CAS No.: 1313731-99-5
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TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 μM . TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats .
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7 Cited Publications
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DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with an IC50 of ～0.1-0.4 μM. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9 .
1
1 Cited Publications
Cat. No.: HY-161834
CAS No.: 2140901-88-6
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RG100204 is a selective, orally available inhibitor of the aquaporin AQP9. RG100204 directly inhibits AQP9 channel function, preventing the transmembrane transport of water, glycerol, and H 2O 2. RG100204 reduces the activation of the NLRP3 inflammasome and p38 MAPK signaling pathways, thereby alleviating inflammation and pyroptosis. RG100204 reduces multi-organ dysfunction in a mouse sepsis model and shows glucose-regulating effects in diabetic db/db mice .
1
1 Cited Publications
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively .
1
1 Cited Publications
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AER-271, a phosphonate proagent derivative of AER-270, is an aquaporin-4 (AQP4) inhibitor for the research of acute ischemic stroke .
Cat. No.: HY-W176557
CAS No.: 877459-36-4
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TGN-073 is an orally active, blood-brain barrier-permeable aquaporin 4 (AQP4) modulator. TGN-073 increases the uptake and distribution of brain MRI tracers in the brain parenchyma and reduces the levels of insoluble amyloid β-40 and β-42. TGN-073 can be used in research related to Alzheimer's disease, dementia, traumatic brain injury and pain .
Cat. No.: HY-N3097
CAS No.: 18836-52-7
Cat. No.: HY-174166
CAS No.: 1021869-59-9
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AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis .
Cat. No.: HY-N4246
CAS No.: 382148-47-2
Cat. No.: HY-P10887
CAS No.: 2988012-71-9
Synonyms: AV-001
Target:
Tie ANGPTL SARS-CoV Aquaporin TNF Receptor PAI-1 CXCR P-selectin
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Cat. No.: HY-N6016R
CAS No.: 382146-66-9
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Cat. No.: HY-P5513
CAS No.: 1643595-65-6
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Cat. No.: HY-P10937
CAS No.: 2891466-35-4
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Cat. No.: HY-P10937A
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Cat. No.: HY-E70797
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CAMK2 is involved in the regulation of cellular processes in a variety of tissues. One member, CAMK2δ CAMK2D is involved in vasopressin signaling in the renal collecting duct, which controls water excretion through regulation of the water channel aquaporin-2 (AQP2). Biotin-CaMK2δ CAMK2D Recombinant Human Active Protein Kinase is obtained by expressing CaMK2δ CAMK2D proteins and is biotinylated .
Cat. No.: HY-N4246R
CAS No.: 382148-47-2
Cat. No.: HY-N3097R
CAS No.: 18836-52-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
