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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
39 Results for "
Arg1
" in MedChemExpress (MCE) Product Catalog:
Products (39)
39 Results for "Arg1" in MCE Product Catalog:
20
20 Cited Publications
Target:
Research Areas:
Cardiovascular Disease Infection Inflammation/Immunology Cancer
(R)-GNE-140 is a potent inhibitor of lactate dehydrogenase (LDH) A, B and C, with IC50 values of 3, 5 and 5 nM against LDHA, LDHB, LDHC, respectively. (R)-GNE-140 blocks the conversion of pyruvate to lactate, reduces lactate production and histone lysine lactylation, and inhibits glycolysis. (R)-GNE-140 attenuates cardiac hypertrophy, alleviates PM2.5-induced pulmonary inflammation and fibrosis, blocks MRSA-induced Arg1 expression. (R)-GNE-140 is applicable to research related to pathological cardiac hypertrophy, pulmonary fibrosis, MRSA infection and pancreatic cancer [1] .
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1 Cited Publications
Cat. No.: HY-P71833
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Arg1Arginase-1; EC 3.5.3.1; Liver-type Arginase; Type I Arginase
Species:
Source:
Cat. No.: HY-N14001
CAS No.: 2227550-73-2
Cat. No.: HY-145331A
Purity: ≥90.0%
ARG1-IN-1 (Compound 3) hydrochloride is an orally active arginase inhibitor with an IC50 value of 29 nM. ARG1-IN-1 hydrochloride can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 hydrochloride is applicable for tumor research [1].
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Cat. No.: HY-145331
CAS No.: 2376189-62-5
ARG1-IN-1 (Compound 3) is an orally active arginase inhibitor with an IC50 value of 29 nM. ARG1-IN-1 can inhibit serum arginase activity and increase arginine levels in mouse tumor models. ARG1-IN-1 is applicable for tumor research [1].
Cat. No.: HY-RS17033
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Arg1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Arg1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P3881
CAS No.: 115760-58-2
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Cat. No.: HY-P3880
CAS No.: 84676-91-5
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Cat. No.: HY-RS00907
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ARG1 Human Pre-designed siRNA Set A contains three designed siRNAs for ARG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: NCX 4016
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Nitroaspirin (NCX 4016) is an orally active inhibitor of ARG1 and NOS2. Nitroaspirin reduces ARG1 enzymatic activity via the STAT6-mediated signaling pathway, and feedback-inhibits the catalytic activity of NOS2 in a NO-releasing group-dependent manner. Nitroaspirin continuously releases intracellular NO, inducing redox-dependent loss of cell viability. Nitroaspirin also exerts anti-angiogenic effects by causing endothelial barrier dysfunction, and effectively inhibits the proliferation of Cisplatin (HY-17394)-resistant human ovarian cancer cells . Nitroaspirin can be used in research related to colon cancer, breast cancer and Cisplatin-resistant human ovarian cancer [1] .
Cat. No.: HY-N11451
CAS No.: 25541-09-7
Synonyms: LNFP-III
Category:
Cat. No.: HY-P11405
CAS No.: 122481-75-8
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Cat. No.: HY-169859
CAS No.: 3035217-40-1
Research Areas:
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model [1].
Cat. No.: HY-RS23477
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Arg1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Arg1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P1490
CAS No.: 16875-11-9
Synonyms: Des-Arg1-bradykinin
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Cat. No.: HY-P3225
CAS No.: 143077-65-0
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Cat. No.: HY-161061
CAS No.: 2377392-07-7
Arginase inhibitor 7 (compound A17) is an arginase (ARG1) inhibitor, with an IC50 of 0.16 μM. Arginase inhibitor 7 has high oral bioavailability [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
