35 Results for "

Chinese hamster ovary cell

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "Chinese hamster ovary cell" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-17372
CAS No.: 162011-90-7
Synonyms: MK 966
Target:  

COX

Research Areas:  

Inflammation/Immunology Cancer

Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W017113
CAS No.: 149-30-4
2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR) , inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity . 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1 . 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC50 value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis . 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats . 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-19436
CAS No.: 252920-94-8
Synonyms: GW 427353
Target:  

Adrenergic Receptor

Research Areas:  

Metabolic Disease Endocrinology

Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM . Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome .
loading...
    loading...
Cat. No.: HY-P99828
CAS No.: 1869928-62-0
Synonyms: PF-06523435; hu24

Target:  

ADC Antibodies RET PERK ROR

Research Areas:  

Cancer

Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .
loading...
    loading...
Cat. No.: HY-P1037
CAS No.: 52906-92-0
Target:  

Motilin Receptor

Research Areas:  

Others

Motilin (26-47), human, porcine is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
loading...
    loading...
Cat. No.: HY-P99865
CAS No.: 2550560-20-6
Synonyms: AK-119

Target:  

CD73

Research Areas:  

Others

Dresbuxelimab (AK-119) is an IgG-κ monoclonal antibody targeting CD73. The expression system is usually CHO (Chinese Hamster Ovary) cells .
loading...
    loading...
Cat. No.: HY-N12109
CAS No.: 585-23-9
Albizziin is an amino acid analog with activity as a competitive inhibitor of asparagine synthetase. Albizziin has been used to isolate Chinese hamster ovary cell mutants with altered levels of the target enzyme. Several mutational classes of albizziin can be distinguished based on cross-resistance to β-aspartic hydroxamic acid. Studies on asparagine synthetase have shown that resistance to albizziin may be associated with altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification .
loading...
    loading...
Cat. No.: HY-B0528AR
CAS No.: 770-05-8
Synonyms: (±)-p-Octopamine hydrochloride (Standard)
Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
loading...
    loading...
Cat. No.: HY-P99869
CAS No.: 2393651-11-9

Target:  

Interleukin Related

Research Areas:  

Others

Ebdarokimab (AK101) is a humanized IgG1-κ antibody, usually expressed in CHO (Chinese Hamster Ovary) cells .
loading...
    loading...
Cat. No.: HY-117507
CAS No.: 149654-41-1
Target:  

5-HT Receptor

Research Areas:  

Neurological Disease

U92016A hydrochloride is a potent, metabolically stable, orally acitive 5-HT1A receptor agonist with an exceptionally high degree of intrinsic activity . U92016A hydrochloride binds with high affinity to human 5-HT1A receptors expressed in Chinese hamster ovary cells (Ki=0.2 nM) .
loading...
    loading...
Cat. No.: HY-P991114
CAS No.: 2921564-55-6

Target:  

FLT3

Research Areas:  

Inflammation/Immunology

Adezkibart is a human monoclonal antibody immunosuppressant targeting the human FMS-like tyrosine kinase 3 ligand (FLT3LG). Adezkibart is found in the Chinese hamster ovary cell line CHO-K1, which binds to FLT3LG to block the relevant signaling pathway, inhibits the immune response, and exerts immunosuppressive activity. Adezkibart is promising for research of immune-related diseases .
loading...
    loading...
Cat. No.: HY-118944
CAS No.: 244192-93-6
Target:  

Adrenergic Receptor

Research Areas:  

Endocrinology

L-748328 is a potent and selective human β3-adrenergic receptor antagonist. L-748328 has a Ki of 3.7 nM against human cloned β3-AR expressed in Chinese hamster ovary (CHO) cells. In addition, L-748328 inhibits the lipolytic response induced by the β3-AR agonist L-742791 in isolated non-human primate adipocytes .
loading...
    loading...
Cat. No.: HY-P99892
CAS No.: 2140172-41-2
Synonyms: PR-1594407; DC-1630423

Target:  

EGFR

Research Areas:  

Others

Serclutamab is a humanized chimeric antibody targeting EGFR IgG1-κ. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
loading...
    loading...
Cat. No.: HY-114128
CAS No.: 1192451-26-5
Synonyms: NN-7088; NN 7170

Target:  

Factor VIII

Research Areas:  

Others

Turoctocog alfa pegol is a recombinant coagulation factor VIII (FVIII) from chinese hamster ovary (CHO) cells. Turoctocog alfa pegol can be used for researching haemophilia A .
loading...
    loading...
Cat. No.: HY-P99844
CAS No.: 2307144-64-3
Synonyms: ALPN-202; CD80 vIgD-Fc

Target:  

CTLA-4

Research Areas:  

Cancer

Davoceticept (ALPN-202; CD80 vIgD-Fc) is a variant CD80 vIgD-Fc fusion protein targeting CTLA-4 and PD-L1. Davoceticept consists of the (1-107) fragment of CD80 linked to IGHG1 Fc via a peptidyl linker. The expression system of Davoceticept is usually CHO (Chinese Hamster Ovary) cells .
loading...
    loading...
Cat. No.: HY-17372S
CAS No.: 544684-93-7
Rofecoxib-d5 is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells) .
loading...
    loading...
Cat. No.: HY-P99871
CAS No.: 2304800-90-4
Synonyms: AK102

Target:  

PCSK9

Research Areas:  

Others

Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells .
loading...
    loading...
Cat. No.: HY-116822
CAS No.: 264618-44-2
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

SSR 146977 is a potent and selective antagonist of the tachykinin NK3 receptor. SSR 146977 inhibits the binding of radioactive neurokinin B to NK3 receptors in Chinese hamster ovary cells, with a Ki of 0.26 nM .
loading...
    loading...
Cat. No.: HY-17372R
CAS No.: 162011-90-7
Synonyms: MK 966 (Standard)
Target:  

Reference Standards COX

Research Areas:  

Inflammation/Immunology Cancer

Rofecoxib (Standard) is the analytical standard of Rofecoxib. This product is intended for research and analytical applications. Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 μM in U937 cells and > 15 μM in Chinese hamster ovary cells).
loading...
    loading...
Cat. No.: HY-P99864
CAS No.: 2171034-71-0
Synonyms: ZTS-00521505

Target:  

Interleukin Related

Research Areas:  

Others

Dovanvetmab (ZTS-00521505) is an IgG1-κ antibody targeting Felcat IL31. Mainly expressed by CHO (Chinese Hamster Ovary) cells .
loading...
    loading...