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DAG

" in MedChemExpress (MCE) Product Catalog:

38

Inhibitors & Agonists

6

Biochemical Assay Reagents

1

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1

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7

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3

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1

Isotope-Labeled Compounds

7

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4

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141572

    sn-1,2-Dioleoylglycerol; 18:1/18:1-DG

    Drug Derivative Metabolic Disease
    1,2-Dioleoyl-sn-glycerol (sn-1,2-Dioleoylglycerol; 18:1/18:1-DG) is a glycerolipid located on the plasma membrane. 1,2-Dioleoyl-sn-glycerol consists of two fatty acid chains covalently linked to a single glycerol molecule by means of an ester bond. 1,2-Dioleoyl-sn-glycerol is an analog of the protein kinase C-activating second messenger DAG. 1,2-Dioleoyl-sn-glycerol has been used as a source of diacylglycerol in the diacylglycerol O-acyltransferase 1 (DGAT1) assay. 1,2-Dioleoyl-sn-glycerol can induce acrosome reaction in human sperm .
    1,2-Dioleoyl-sn-glycerol
  • HY-131897
    1-Stearoyl-2-arachidonoyl-sn-glycerol
    1 Publications Verification

    PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .
    1-Stearoyl-2-arachidonoyl-sn-glycerol
  • HY-W075903

    Cobalt hexammine trichloride; Hexaamminecobalt trichloride

    Biochemical Assay Reagents SOD Glutathione S-transferase Metabolic Disease Cancer
    Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434)-induced hepatocarcinoma .
    Hexaamminecobalt(III) chloride
  • HY-147358

    Emitasvir diphosphate; DAG-181 diphosphate

    HCV Infection
    Yimitasvir diphosphate (Emitasvir diphosphate; DAG-181 diphosphate) is an orally active inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Yimitasvir diphosphate is applicable to research related to HCV infection .
    Yimitasvir diphosphate
  • HY-112552

    DSG; 1,2-Dioctadecanoyl-sn-glycerol

    Endogenous Metabolite Biochemical Assay Reagents Others
    1,2-Distearoyl-sn-glycerol (DSG) is a glyceride compound. 1,2-Distearoyl-sn-glycerol can be used as an internal standard for the analysis of molecular species of diacylglycerol (DAG) and other phospholipids in rat brain .
    1,2-Distearoyl-sn-glycerol
  • HY-P10557

    Biochemical Assay Reagents Neurological Disease
    DAG peptide is a cyclic peptide. DAG peptide selectively recognizes a subset of astrocytes that are activated in Alzheimer's disease (AD) starting at an early stage of the disease. DAG peptide can be used as a tool to enhance the delivery of therapeutics and imaging agents to sites of vascular changes and astrogliosis in diseases associated with neuroinflammation .
    DAG peptide
  • HY-131648
    1-Oleoyl-2-acetyl-sn-glycerol
    1 Publications Verification

    Drug Derivative PKC TRP Channel Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of diacylglycerol (DAG) and can activate Protein kinase C (PKC). 1-Oleoyl-2-acetyl-sn-glycerol can activate the TRPC channels-mediated specific Ca 2+ influx. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate superoxide-generation from human neutrophils. 1-Oleoyl-2-acetyl-sn-glycerol stimulates the formation of phosphatidylinositol 4-phosphate in intact human platelets. 1-Oleoyl-2-acetyl-sn-glycerol can stimulate ascites tumor cell proliferation .
    1-Oleoyl-2-acetyl-sn-glycerol
  • HY-W127409

    Biochemical Assay Reagents Others
    1,2-Dimyristoyl-rac-glycerol (C14:0) is a carboxylic acid ester, glycerolipid and diglyceride with an additional myristoyl group that facilitates interactions between proteins and lipids. Can be used as detergent or reagent. It plays a role in cell biology experiments involving the metabolism and metabolic pathways of glycerolipids. As a diglyceride, this substance consists of two fatty acid chains covalently bonded in the 1,2-form to a glycerol molecule. The diglyceride (DAG) study investigated the process by which DAG is depleted to inhibit fat accumulation. Reagent grade, for research use only.
    1,2-Dimyristoyl-rac-glycerol
  • HY-136190

    TRP Channel Neurological Disease
    TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of TRPC6 channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca 2+ concentrations ([Ca 2+]i) in TRPC6-expressing HEK293 cells with an EC50 of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals .
    TRPC6-PAM-C20
  • HY-N15895

    CDP-DAG ammonium; Dihexadecanoyl ammonium; Cytidine Diacylglycerol ammonium

    Biochemical Assay Reagents Others
    16:0 CDP DG ammonium is a liponucleotide.
    16:0 CDP DG ammonium
  • HY-141574

    PKC Others
    1,2-Didecanoyl-sn-glycerol is an analog of the PKC-activating second messenger DAG. Although the biological activities of 1,2-didecanoyl-sn-glycerol have not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.
    1,2-Didecanoyl-Sn-glycerol
  • HY-P2817

    PLCs

    Phospholipase Infection Metabolic Disease
    Phospholipase C (PLCs) is a class of phospholipases. Phospholipase C participates in cellular signaling and regulation by virtue of its ability to hydrolyze membrane phospholipids into di-acyl-glycerol (DAG) and inositol triphosphate (IP3), which further causes the activation of other signaling pathways involved in various processes, including immune response .
    Phospholipase C
  • HY-111527

    Calcium Channel Neurological Disease
    PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
    PPZ2
  • HY-147358A

    Emitasvir; DAG-181

    HCV Infection
    Yimitasvir (Emitasvir; DAG-181) is an orally active inhibitor of hepatitis C virus (HCV) nonstructural protein 5A (NS5A). Yimitasvir is applicable to research related to HCV infection .
    Yimitasvir
  • HY-118442

    Tetradecasphing-4-enine

    PKC Cancer
    Sphingosine (d14:1) (Tetradecasphing-4-enine), a sphingolipid, is a potent Protein kinase C (PKC) inhibitor. Sphingosine (d14:1) prevents its interaction with sn-1,2-diacylglycerol (DAG)/Phorbol esters .
    Sphingosine (d14:1)
  • HY-158800

    Biochemical Assay Reagents Others
    1-NBD-decanoyl-2-decanoyl-sn-glycerol is a diacylglycerol (DAG) derivative, which is labeled with a fluorescent group NBD. 1-NBD-decanoyl-2-decanoyl-sn-glycerol is the substrate for diacylglycerol kinase (DGK), and can be used for quantitative detection of the DGF enzyme kinetics in vitro, and the changes in DAG and PA during cell signaling .
    1-NBD-decanoyl-2-decanoyl-sn-glycerol
  • HY-117115

    Biochemical Assay Reagents Others
    1,2-Dihexanoyl-sn-glycerol is an analog of protein kinase C (PKC) that activates the second messenger diacylglycerol (DAG). Although the biological activity of 1,2-dicaproyl-sn-glycerol has not been well characterized, it is expected to behave similarly to 1,2-dioctanoyl-sn-glycerol.
    1,2-Dihexanoyl-sn-glycerol
  • HY-117168

    Endogenous Metabolite Metabolic Disease
    1,2-Dilinoleoyl-sn-glycerol is a diacylglycerol (DAG) with linoleic acid (HY-N0729) (18:2) side chains attached at both the sn-1 and sn-2 positions . 1,2-Dilinoleoyl-sn-glycerol can be prepared from L-dilinoleoylphosphatidylcholine via hydrolysis with phospholipase C .
    1,2-Dilinoleoyl-sn-glycerol
  • HY-W145699

    Biochemical Assay Reagents Endogenous Metabolite Others
    D-myo-Inositol 4-mono-phosphate, also known as IMP, is a phosphorylated form of inositol that is commonly found in various metabolic pathways, especially in the biosynthesis of phospholipids and cell signaling molecules. D-myo-Inositol 4-mono-phosphate has unique chemical properties that make it an important intermediate in the production of second messengers, such as inositol triphosphate (IP3) and diacylglycerol (DAG), which signal in cells plays a key role in. D-myo-Inositol 4-mono-phosphate is also used in dietary supplements and pharmaceuticals because of its potential health benefits, including improved insulin sensitivity and cognitive function.
    D-myo-Inositol 4-monophosphate
  • HY-RS03519

    Small Interfering RNA (siRNA) Others

    DAG1 Human Pre-designed siRNA Set A contains three designed siRNAs for DAG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DAG1 Human Pre-designed siRNA Set A
    DAG1 Human Pre-designed siRNA Set A
  • HY-E70852

    PKC Cancer
    PKC is a family of serine/threonine kinases involved in several processes including proliferation, differentiation, apoptosis, and migration. PKCα is a classical PKC isoform that contains a C1 domain that binds to diacylglycerol (DAG). PKCα Recombinant Human Active Protein Kinase is a recombinant PKCα protein that can be used to study PKCα-related functions .
    PKCα Recombinant Human Active Protein Kinase
  • HY-149489

    PKC Neurological Disease
    JH-131e-153, a diacylglycerol (DAG)-lactone, is a small molecule activator of Munc13-1, targeting the C1 domain. The activation sequence of JH-131e-153 on Munc13-1 is WT>I590≈R592A≈W588A. The C1 domain of Munc13-1 and protein kinase C (PKC) are homologous in sequence and structure. The activation sequence of JH-131e-153 on Munc13-1 and PKC was PKCα>Munc13-1>PKCε. JH-131e-153 regulates neuronal processes through Munc13-1 and can be further used in the study of neurodegenerative diseases .
    JH-131e-153
  • HY-143691

    Liposome Others
    MGlc-DAG, a glycoglycerolipid, can be used for the synthesis of drug delivery compound .
    MGlc-DAG
  • HY-RS18922

    Small Interfering RNA (siRNA) Others

    Dag1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dag1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dag1 Mouse Pre-designed siRNA Set A
    Dag1 Mouse Pre-designed siRNA Set A
  • HY-N15782

    TRP Channel Neurological Disease
    18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that allows rapid photoactivation of these DAG-sensitive TRP channels .
    18:0-PhoDAG
  • HY-105953

    ONO-995

    Prostaglandin Receptor Endocrinology
    Froxiprost (ONO-995) is a PGF2α (HY-12956) analogue. Froxiprost stimulates thymidine uptake, 1,2 diacylglycerol (1,2-DAG) accumulation, and phosphorylcholine formation in osteoblast-like MC3T3-E1 cells .
    Froxiprost
  • HY-N15358

    Drug Metabolite Cardiovascular Disease Metabolic Disease
    15:0-18:1 DG is a type of diacylglycerol (DAG). 15:0-18:1 DG can be produced by hydrolysis of triacylglycerol (TAG) in butter fat. 15:0-18:1 DG is promising for research of obesity, cardiovascular diseases, and dietary interventions .
    15:0-18:1 DG
  • HY-W011176

    1,2-Dioctanoyl-sn-glycerol

    Endogenous Metabolite Others
    (S)-3-Hydroxypropane-1,2-diyl dioctanoate (1,2-Dioctanoyl-sn-glycerol) is a cell-permeable analog of the PKC-activating second messenger DAG. (S)-3-Hydroxypropane-1,2-diyl dioctanoate induces acrosome reaction in human sperm.
    (S)-3-Hydroxypropane-1,2-diyl dioctanoate
  • HY-P992223

    Transmembrane Glycoprotein Neurological Disease
    Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is a human monoclonal antibody against DAG1/Dystroglycan. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) can bind specifically to the α and β subunits of the dystroglycan protein complex. Anti-DAG1/Dystroglycan Antibody (DAG-6F4) is applicable to research related to muscular dystrophy .
    Anti-DAG1/Dystroglycan Antibody (DAG-6F4)
  • HY-147358C

    (1R,4S)-Emitasvir diphosphate; (1R,4S)-DAG-181 diphosphate

    HCV Infection
    Yimitasvir (Emitasvir) diphosphate is an orally active hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor and can be used for research of chronic hepatitis C virus infection .
    (1R,4S)-Yimitasvir diphosphate
  • HY-131897S

    Isotope-Labeled Compounds PKC TRP Channel Endogenous Metabolite Neurological Disease
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .
    1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol
  • HY-134200A

    HIF/HIF Prolyl-Hydroxylase Metabolic Disease
    1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1) is a 1:1 mixture of 1-Palmitoyl-2-oleoyl-sn-glycerol (HY-134200) and 1-Oleoyl-3-palmitoylglycerol (HY-W583685). 1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1) is the major active component of diacylglycerol (DAG) and a hypoxia-inducible factor (HIF) inducer .
    1-Palmitoyl-2-oleoyl-sn-glycerol, 1-Oleoyl-3-palmitoylglycerol (1:1)
  • HY-N15353

    Bacterial Infection
    1-Palmitoyl-2-linoleoyl-sn-glycerol is a diacylglycerol (DAG)-type lipid signaling molecule found in the coralloid roots of Cycas revoluta, and serves as a major active component of the plant-secreted hormogonium-inducing factor (HIF). At a concentration of 1 nmol/disc (approximately 0.6 µg), 1-palmitoyl-2-linoleoyl-sn-glycerol can significantly induce the differentiation of filamentous aggregates of Nostoc into motile hormogonia, thereby promoting chemotaxis toward host roots and the establishment of symbiosis. This compound holds significant research and application potential in areas such as plant–microbe interactions, rhizosphere signaling pathways, and nitrogen-fixing symbiosis .
    1-Palmitoyl-2-linoleoyl-sn-glycerol
  • HY-111297

    Biochemical Assay Reagents Cancer
    BMVC4 is a G-quadruplex (G4) stabilizer of the human telomeric sequence d[AG3(T2AG3)3]. Screening by circular dichroism (CD) spectroscopy revealed that BMVC4 is more suitable as the core molecule of G4 stabilizers than BMVC. The results showed that BMVC4-12C and BMVC4-8C3O are better candidates for G4 stabilizers and are worthy of further study. A simple and rapid screening method based on Cu2+-induced G4 unfolding can be used to find better G4 stabilizers for potential anticancer applications. CD results showed that the trivalent cations of 9-substituted BMVC derivatives are more suitable as G4 stabilizers than the divalent cations of BMVC. In addition, by monitoring the disappearance of the 291 nm CD band of human telomeres after Cu2+ addition, it was found that the core molecule of G4 stabilizer BMVC4 has better stability.
    BMVC4
  • HY-RS25412

    Small Interfering RNA (siRNA) Others

    Dag1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dag1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dag1 Rat Pre-designed siRNA Set A
    Dag1 Rat Pre-designed siRNA Set A
  • HY-RS23774

    Small Interfering RNA (siRNA) Others

    Clu Rat Pre-designed siRNA Set A contains three designed siRNAs for Clu gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Clu Rat Pre-designed siRNA Set A
    Clu Rat Pre-designed siRNA Set A
  • HY-E70949

    PKC Metabolic Disease
    Protein Kinase C,Rat (EC 2.7.1.37) is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. Protein Kinase C in turn are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca 2+).
    Protein Kinase C,Rat
  • HY-172742

    Biochemical Assay Reagents Others
    Dioctanoyl PI(3,4)P2 (sodium) is a synthetic analog of natural Ptdlns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. Dioctanoyl PI(3,4)P2 (sodium) contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural Ptdlns .
    Dioctanoyl PI(3,4)P2 sodium

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