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Results for "

DMF

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Autophagy (3) Biochemical Assay Reagents (3) COX (2) Cytochrome P450 (1) DNA/RNA Synthesis (14) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (5) Endogenous Metabolite (6) Environmental Pollutants (1) ERK (1) Fluorescent Dye (7) Glycosidase (1) GPR109A (5) HIV (3) IKK (1) Isotope-Labeled Compounds (3) Keap1-Nrf2 (6) NF-κB (4) Nucleoside Antimetabolite/Analog (10) p38 MAPK (3) Phosphodiesterase (PDE) (1) Phosphoramidites (14) Reactive Oxygen Species (ROS) (3) Reference Standards (6) SHP2 (1) TGF-beta/Smad (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (16) Metabolic Disease (6) Neurological Disease (9)
Click Chemistry:	Azide (1)
Oligonucleotides:	Adenosine (2) Guanosine (1) Nucleotide Analogs (2) Nucleoside Analogs (5) Adenine (1) Cytosine (1) Uracil (1) Phosphoramidites (14) Guanine (11)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17363

Dimethyl fumarate Maximum Cited Publications 56 Publications Verification	Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite	Infection Neurological Disease Inflammation/Immunology Cancer
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-D0819

CY5-SE 35+ Cited Publications Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-W015883

Fumaric acid 4 Publications Verification	Environmental Pollutants Endogenous Metabolite NF-κB p38 MAPK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .

HY-103252

Monomethyl fumarate 5+ Cited Publications	GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-DY2002

X-GAL (solution)	Fluorescent Dye Glycosidase	Others
X-GAL (BCIG) (solution) is a widely used chromogenic β-galactosidase substrate. X-GAL is a colorless compound until cleaved by β-galactosidase, at which point X-GAL turns to an insoluble and detectable blue compound, making X-GAL particularly useful in techniques such as blue-white screening for cloning in bacteria. X-GAL can also be used for detection of β-galactosidase activity . Solvent and Concentration: DMF: 20 mg/mL

HY-138585

*DMT-dG(dmf) Phosphoramidite*	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Others
DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides

HY-W015883A

Fumaric acid disodium 4 Publications Verification	Endogenous Metabolite NF-κB p38 MAPK	Cardiovascular Disease Inflammation/Immunology
Fumaric acid disodium is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid disodium exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid disodium can be used in the study of pregnancy-induced hypertension .

HY-Y1078

DMF-DMA N-Dimethoxymethyl-N,N-dimethylamine	Biochemical Assay Reagents	Others
DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .

HY-100375

Diroximel fumarate 4 Publications Verification ALKS 8700; BIIB098	Keap1-Nrf2	Inflammation/Immunology
Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity .

HY-W402064

N-Acetyladenosine	Nucleoside Antimetabolite/Analog	Others
N-Acetyladenosine is an adenosine analog and an adenosine N ⁶-acylated derivative. N-Acetyladenosine can be produced via the heterolytic reaction between adenosine and diacetyl peroxide .

HY-W003486

5,7-Dichloropyrazolo[1,5-a]pyrimidine	Phosphodiesterase (PDE)	Neurological Disease Cancer
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a PDE10A inhibitor with a K_i of 24 μM. 5,7-Dichloropyrazolo[1,5-a]pyrimidine serves as a key intermediate in the synthesis of 5,7-disubstituted pyrazolo[1,5-a]pyrimidine derivatives (HIV-1 non-nucleoside reverse transcriptase inhibitors). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used for the research of schizophrenia .

HY-17363S1

Dimethyl fumarate-d2	Autophagy HIV Keap1-Nrf2 Endogenous Metabolite Reactive Oxygen Species (ROS)	Cancer
Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate . Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Biochemical Assay Reagents COX	Inflammation/Immunology Cancer
5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-177360

RNA splicing modulator-4	DNA/RNA Synthesis	Neurological Disease Cancer
RNA splicing modulator-4 is an RNA splicing modulator. RNA splicing modulator-4 controls the inclusion or exclusion of specific exons in precursor mRNA (pre-mRNA) by regulating alternative splicing events, thereby altering the coding sequence and function of mature mRNA. RNA splicing modulator-4 shows promise for research into neurodegenerative diseases (such as Huntington's disease) and cancers .

HY-W015883R

Fumaric acid (Standard)	Reference Standards Endogenous Metabolite NF-κB p38 MAPK	Metabolic Disease Inflammation/Immunology
Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification	GPR109A Isotope-Labeled Compounds Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-DY1063

CY5-SE (solution)	Fluorescent Dye	Others
Cy5-SE (Cy5 NHS Ester) (solution) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm) :649, Emission (nm) : 670. Solvent and concentration: DMSO: 10 mM

HY-131030

Janelia Fluor® 669, SE JF669, SE; JF669, NHS	Fluorescent Dye	Others
Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-17363R

Dimethyl fumarate (Standard)	Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite	Infection Neurological Disease Inflammation/Immunology Cancer
Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-155786

3,7-DMF	TGF-beta/Smad	Others
3,7-DMF is an orally active inhibitor of TGF-β1-induced activation of HSCs. 3,7-DMF induces antioxidant genes and quenches ROS away, which can be used to study liver fibrosis .

HY-W087919

5-Methyl-2-furanmethanol	Cytochrome P450	Others
5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP) .

HY-43066

*DMT-2'-O-TBDMS-G(dmf)-CE-phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2-(((E)-(dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-103252S2

Monomethyl fumarate-d2	Isotope-Labeled Compounds GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate-d₂ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-W998687

Cy5 dimethyl	Fluorescent Dye	Others
Cy5 dimethyl is a free non-activated dye. This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration.

HY-147320

*3'-DMTr-dG(dmf)*	DNA/RNA Synthesis Phosphoramidites	Others
3'-DMTr-dG(dmf) is a guanosine derivative used in the synthesis of nucleic acids .

HY-W141393

*2'-OMe-dmf-G-CE-Phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
2'-OMe-dmf-G-CE-Phosphoramidite is a phosphorite monomer that can be used in the synthesis of oligonucleotides.

HY-W1119950

*3'-NH-Tr-2',3'-DMF-ddA- 5'-CE-Phosphoramidite*	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite is an adenine nucleotide monomer precursor used in solid-phase synthesis of oligonucleotides, particularly modified oligonucleotides, such as those with DNA chain end modifications. 3'-NH-Tr-2',3'-DMF-ddA-5'-CE-Phosphoramidite, with trityl (Tr), cyanoethyl (CE), and dimethylformamidine (DMF) protecting groups, is a ddNTP adenosine nucleoside useful in applications such as solid-phase oligonucleotide synthesis, probe design, and chain-termination sequencing .

HY-138607

*5'-O-DMT-N2-DMF-dG*	Phosphoramidites DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
5'-O-DMT-2'-O-TBDMS-rI is a modified nucleoside. 5'-O-DMT-2'-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.

HY-W098689

Dmf-dg 2'-Deoxy-N2-dimethylaminomethylene-guanosine	Nucleoside Antimetabolite/Analog	Others
Dmf-dg (2'-Deoxy-N2-dimethylaminomethylene-guanosine) is a deoxyguanosine (dG) nucleoside protected by the dimethylaminomethylamidine (DMF) base and can be used for oligonucleotide synthesis .

HY-W1119943

*2'-OMe-8-Me-DMF-G Phosphoramidite*	Nucleoside Antimetabolite/Analog	Others
2'-OMe-8-Me-DMF-G Phosphoramidite is a phosphoramidite compound containing modified guanine (G) and a dimethoxytrityl (DMT) group. 2'-OMe-8-Me-DMF-G Phosphoramidite can be used in RNA oligonucleotide synthesis.

HY-103252R

Monomethyl fumarate (Standard)	Reference Standards GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate (Standard) is the analytical standard of Monomethyl fumarate. This product is intended for research and analytical applications. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].

HY-D2231

Cy3.5 maleimide	ADC Payload	Others
Cy3.5 maleimide is a relatively water-soluble fluorescent dye. Cy3.5 maleimide is soluble in organic solvents, including DMF, DMSO and acetonitrile and so on .

HY-W048502

8-Mercaptoadenosine 8-Thioadenosine	Drug Intermediate	Others
8-Mercaptoadenosine is a nucleoside derivative that can be synthesized in DMF-aqueous solution at room temperature using NaSH via the corresponding 8-bromo compounds, and it is an intermediate in the synthesis of the substrate for RNA pyrophosphorylase .

HY-103252S1

Monomethyl fumarate-d5	Isotope-Labeled Compounds GPR109A Drug Metabolite	Neurological Disease Inflammation/Immunology
Monomethyl fumarate-d₅ is deuterium labeled Monomethyl fumarate (HY-103252) . Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-164480

GTCpFE	IKK NF-κB	Inflammation/Immunology Cancer
GTCpFE inhibits IKKα/β in the NF-κB pathway with anti-inflammatory activities and blocks p65 nuclear entry, which consists of Dimethyl fumarate (DMF) (HY-17363) linked to Aspirin (ASA) (HY-14654). GTCpFE exhibits selective anti-cancer stem-like cell (CSC) activity by reducing mammosphere growth and the CD44 ⁺ CD24 ^- immunophenotype. GTCpFE inhibits breast cancer stem cells, an important NFκB- and PGE2-dependent phenotype in aggressive cancers .

HY-D2759

Cyanine3B azide	Fluorescent Dye	Others
Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.

HY-Y0543R

5-Methylfurfural (Standard)	Biochemical Assay Reagents Reference Standards COX	Inflammation/Immunology Cancer
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-174322

SHP2-IN-38	SHP2 ERK Fluorescent Dye	Cancer
SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC₅₀ values of 2.89 μM (SHP2), 8.73 μM (SHP1), 11.08 μM (PTP1B), 33.07 μM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC₅₀ of 7.90 μM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish.

HY-W870114

*N2-DMF-2'-O-Methylguanosine*	Nucleoside Antimetabolite/Analog	Metabolic Disease
N2-DMF-2'-O-Methylguanosine is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W1130272

*DMT-dG(dmf)-CE-Phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
DMT-dG(dmf)-CE-Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-W1121772

*8-Oxo-dG(dmf) phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
8-Oxo-dG(dmf)phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-177293

*DMT-G-3'-Ome-(dmf) phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
DMT-G-3'-Ome-(dmf) Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-177294

*DMT-G-3'-F-(dmf) Phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
DMT-G-3'-F-(dmf) Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-178540

*DMTr-dA(dmf)-3'-CE-phosphoramidite*	Nucleoside Antimetabolite/Analog Phosphoramidites	Metabolic Disease
DMTr-dA(dmf)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W782181

*2'-Deoxy-N4-DMF-5'-O-DMT-pseudoisocytidine 3'-CE Phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
2'-Deoxy-N4-DMF-5'-O-DMT-pseudoisocytidine 3'-CE Phosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-W1121759

*DMTr-2'-ara-F-dG(dmf)-3'-CE-phosphoramidite*	Nucleoside Antimetabolite/Analog Phosphoramidites	Metabolic Disease
DMTr-2'-ara-F-dG(dmf)-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W844249

*5'-O-DMTr-2'-O-4'-C-locked-rG(dmf)*	Nucleoside Antimetabolite/Analog	Metabolic Disease
5'-O-DMTr-2'-O-4'-C-Locked-rG(dmf) is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W087919R

5-Methyl-2-furanmethanol (Standard)	Reference Standards Others	Others
5-Methyl-2-furanmethanol (Standard) is the analytical standard of 5-Methyl-2-furanmethanol. This product is intended for research and analytical applications. 5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP)[1][2].

HY-100375R

Diroximel fumarate (Standard) ALKS 8700 (Standard); BIIB098 (Standard)	Reference Standards Keap1-Nrf2	Inflammation/Immunology
Diroximel fumarate (Standard) is the analytical standard of Diroximel fumarate (HY-100375). This product is intended for research and analytical applications. Diroximel fumarate (ALKS 8700) is an orally-active and well-tolerated monomethyl fumarate (MMF) proagent in a controlled-release formulation. Diroximel fumarate is considered as active equivalent to its active metabolite dimethyl fumarate (DMF). Diroximel fumarate has a favorable safety and efficacy profile, has the potential for the study of multiple sclerosis (MS). Diroximel fumarate is a Nrf2 activator that alleviate MGO-induced pain hypersensitivity .

HY-W714978

*5'-O-DMT-3'-Me-dG(dmf)-CE phosphoramidite*	DNA/RNA Synthesis Phosphoramidites	Others
(2R,3S,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-(((E)-(dimethylamino)methylene)amino)-5-methyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite is a phosphoramidite that can be used in the synthesis of oligonucleotides.

Cat. No.	Product Name	Type

HY-D0819

CY5-SE

35+ Cited Publications

Cy5 NHS Ester; Sulfo-Cyanine5 Succinimidyl Ester

Fluorescent Dye

Cy5-SE (Cy5 NHS Ester) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm):649, Emission (nm): 670.

HY-DY2002

X-GAL (solution)

Fluorescent Dye

X-GAL (BCIG) (solution) is a widely used chromogenic β-galactosidase substrate. X-GAL is a colorless compound until cleaved by β-galactosidase, at which point X-GAL turns to an insoluble and detectable blue compound, making X-GAL particularly useful in techniques such as blue-white screening for cloning in bacteria. X-GAL can also be used for detection of β-galactosidase activity .
Solvent and Concentration: DMF: 20 mg/mL

HY-DY1063

CY5-SE (solution)

Fluorescent Dye

Cy5-SE (Cy5 NHS Ester) (solution) is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. This dye requires small amount of organic co-solvent (such as DMF or DMSO) to be used in labeling reaction. This reagent is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides. This reagent also works well in organic solvents for small molecule labeling. Excitation (nm) :649, Emission (nm) : 670.
Solvent and concentration: DMSO: 10 mM

HY-131030

Janelia Fluor® 669, SE JF669, SE; JF669, NHS	Fluorescent Dye
Janelia Fluor 669, SE (JF669, SE), a red fluorescent dye, can be directly reacted with the available thiol-containing HaloTag ligand under mild conditions (DIEA, DMF) to afford a JF669HaloTag ligand in a single step (Ex = 669 nm; Em = 682 nm) . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-W998687

Cy5 dimethyl	Fluorescent Dye
Cy5 dimethyl is a free non-activated dye. This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration.

HY-D2231

Cy3.5 maleimide	Fluorescent Dye
Cy3.5 maleimide is a relatively water-soluble fluorescent dye. Cy3.5 maleimide is soluble in organic solvents, including DMF, DMSO and acetonitrile and so on .

HY-D2759

Cyanine3B azide

Fluorescent Dye

Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.

Cat. No.	Product Name	Type

HY-W015883A

Fumaric acid disodium 4 Publications Verification	Biochemical Assay Reagents
Fumaric acid disodium is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid disodium exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid disodium can be used in the study of pregnancy-induced hypertension .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-17363

Dimethyl fumarate Maximum Cited Publications 56 Publications Verification	Infection Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-W015883

Fumaric acid 4 Publications Verification	Structural Classification Classification of Application Fields Endocrine diseases Metabolic Disease Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Cancer Source Classification	Environmental Pollutants Endogenous Metabolite NF-κB p38 MAPK
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .

HY-W015883A

Fumaric acid disodium 4 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite NF-κB p38 MAPK
Fumaric acid disodium is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid disodium exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid disodium can be used in the study of pregnancy-induced hypertension .

HY-Y0543

5-Methylfurfural 1 Publications Verification	Cornaceae Classification of Application Fields Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Other Diseases Plants Disease Research Fields Source Classification	Biochemical Assay Reagents COX
5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-W015883R

Fumaric acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cancer Source Classification	Reference Standards Endogenous Metabolite NF-κB p38 MAPK
Fumaric acid (Standard) is the analytical standard of Fumaric acid. This product is intended for research and analytical applications. Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .

HY-17363R

Dimethyl fumarate (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS) HIV Autophagy Endogenous Metabolite
Dimethyl fumarate (Standard) is the analytical standard of Dimethyl fumarate. This product is intended for research and analytical applications. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-W087919

5-Methyl-2-furanmethanol	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Dianthus rupicola Biv. Plants Disease Research Fields Source Classification	Cytochrome P450
5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP) .

HY-Y0543R

5-Methylfurfural (Standard)	Structural Classification Microorganisms Cornaceae Cornus officinalis Sieb. et Zucc. Ketones, Aldehydes, Acids Plants Source Classification	Biochemical Assay Reagents Reference Standards COX
5-Methylfurfural (Standard) is the analytical standard of 5-Methylfurfural. This product is intended for research and analytical applications. 5-Methylfurfural is a chemical that can be utilized as food additive, intermediate in the production of agrochemicals, and precursor of certain anti-cancer natural products. 5-Methylfurfural is formed during the photoexposition of ranitidine hydrochloride. 5-Methylfurfural is an organic compound. 5-Methylfurfural has a strong tendency to be further hydrogenated to 2,5-dimethylfuran (DMF). 5-Methylfurfural can predominantly evoke skin inflammation and barrier disintegration. 5-Methylfurfural degrades native DNA through the formation of single-strand breaks .

HY-W087919R

5-Methyl-2-furanmethanol (Standard)	Natural Products other families Dianthus rupicola Biv. Plants Source Classification	Reference Standards Others
5-Methyl-2-furanmethanol (Standard) is the analytical standard of 5-Methyl-2-furanmethanol. This product is intended for research and analytical applications. 5-Methyl-2-furanmethanol is a natural product that can be isolated from the essential oil of D. rupicola Biv.. 5-Methyl-2-furanmethanol also acts as a oxidative product of 2,5 dimethylfuran (DMF) by cytochrome P450 (CYP)[1][2].

Cat. No.	Product Name	Chemical Structure

HY-17363S1

Dimethyl fumarate-d2

Dimethyl fumarate-d₂ is the deuterium labeled Dimethyl fumarate . Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research .

HY-103252S

Monomethyl fumarate-d3 1 Publications Verification
Monomethyl fumarate-d₃ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-103252S2

Monomethyl fumarate-d2
Monomethyl fumarate-d₂ is a deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

HY-103252S1

Monomethyl fumarate-d5
Monomethyl fumarate-d₅ is deuterium labeled Monomethyl fumarate (HY-103252) . Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease .

Cat. No.	Product Name		Classification

HY-D2759

Cyanine3B azide		Azide
Cyanine3B azide for click chemistry conjugation with terminal alkynes via a copper-catalyzed click reaction or strained cyclooctynes via a copper-free click reaction. Cyanine3B is a yellow-emitting cyanine dye that is an improved version of the Cyanine3 fluorophore with significantly higher fluorescence quantum yield and photostability. Due to the fixed conformation, Cyanine3B has the highest emission quantum yield compared to other dyes of this wavelength. This is a non-sulfonated dye that requires an organic co-solvent (DMF, DMSO, or other) for efficient labeling in water.

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