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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Detection limit
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Detection limit" in MCE Product Catalog:
1
1 Cited Publications
Synonyms: 3-Amino-5-morpholinomethyl-2-oxazolidone
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AMOZ is a carcinogenic metabolite of Furaltadone (HY-B1148A), which forms stable tissue residues by covalently binding to proteins as a hapten. AMOZ can be coupled with carrier proteins (such as BSA/OVA) to induce immune response and is released after acid hydrolysis. AMOZ residues can be detected by competitive ELISA method, and the detection limit in the monoclonal antibody 2E5.1 test is as low as 0.16 μg/kg (shrimp sample). AMOZ can be used as a typical marker to monitor drug residues in animal-derived foods in the field of food safety[1][2].
Cat. No.: HY-W110910
CAS No.: 1787-61-7
Cat. No.: HY-W013435
CAS No.: 1758-68-5
Cat. No.: HY-D1262
CAS No.: 1808174-52-8
Synonyms: Thiol-green 2
Cat. No.: HY-136894
CAS No.: 888229-31-0
Cat. No.: HY-D0038
CAS No.: 525560-81-0
Cat. No.: HY-D2204
CAS No.: 2956720-62-8
Cat. No.: HY-P5510
CAS No.: 188530-20-3
Synonyms: HCV NS3 protease substrate
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Cat. No.: HY-D3003
CAS No.: 2522921-17-9
Cat. No.: HY-N11602
CAS No.: 67030-48-2
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Cat. No.: HY-W653727
CAS No.: 139542-32-8
Synonyms: Prochloraz-desimidazole-formylamino
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BTS44596 (Prochloraz-desimidazole-formylamino) is a metabolite of the antifungal agent Prochloraz (HY-B0845). BTS44596 is one of the core target analytes for regulatory monitoring of Prochloraz residue limits in fruits and vegetables as well as for simultaneous detection via LC-MS/MS .
Cat. No.: HY-D3125
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NtHzBtd is a fluorescent probe for detecting Fe 3+. NtHzBtd is applicable to the selective fluorescent detection of Fe 3+ ions and live cell imaging studies. NtHzBtd can selectively coordinate with Fe 3+ to form a 1:1 complex, triggering chelation enhanced quenching (CHEQ) and intramolecular charge transfer (ICT) processes, which result in fluorescence turn-off, thereby enabling sensitive detection of Fe 3+ and live cell fluorescence imaging. After binding to Fe 3+, NtHzBtd reduces fluorescence intensity, exhibits a rapid response property, with a limit of detection of 0.036 μM and a response time of approximately 55 s. The detection wavelengths are Ex/Em = 334/401 nm (solution system) .
Cat. No.: HY-P11934
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Cat. No.: HY-D3244
CAS No.: 1840931-43-2
Cat. No.: HY-D3124
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Gol-SiRhoNox is a Golgi apparatus-targeted fluorescent probe with high selectivity for Fe (II), with a limit of detection of 50 nM. Gol-SiRhoNox integrates a myristoyl motif for Golgi apparatus targeting and a silicon-fused rhodamine N-oxide as the Fe (II)-sensitive moiety. Gol-SiRhoNox is non-fluorescent in its native state; Fe (II)-mediated deoxygenation of the N-oxide triggers fluorescence recovery. Its fluorescent product, Gol-SiR, has excitation/emission wavelengths of 630/665 nm and a maximum absorption wavelength of 655 nm .
Cat. No.: HY-D3418
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BOD-Tz-TMR is a fluorescent probe used for nitric oxide (NO) detection and atherosclerotic plaque imaging.BOD-Tz-TMR has a detection limit of 31 nM for NO. BOD-Tz-TMR functions via Förster resonance energy transfer (FRET) and bioorthogonal reactions, in which the tetrazine linker quenches fluorescence through the energy transfer to dark state (ETDS) mechanism. The interaction of BOD-Tz-TMR with NO triggers a ratiometric shift in fluorescence from BODIPY (Ex/Em: 488 nm/512 nm, green channel) to TMR (Em: 592 nm, red channel). BOD-Tz-TMR labels macrophages through a bioorthogonal reaction with BCN, enabling its targeted accumulation at atherosclerotic plaque sites to detect endogenous NO associated with lesion progression. BOD-Tz-TMR can be used in studies related to atherosclerosis .
Cat. No.: HY-W327027
CAS No.: 314742-00-2
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7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one (Compound 1) is a fluorescent probe for the detection of hydrogen sulfide (H2S). 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one has a low detection limit (4×10 -6 mol/L), good selectivity and high sensitivity. 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one shows almost no cytotoxicity at concentrations of 150 µg/mL. 7-(2,4-Dinitrophenoxy)-4-methyl-2H-chromen-2-one has the excitation peak of 331 nm, and the emission peak about 385 nm in DMSO solvent. Upon the addition of increasing amounts of HS -, the fluorescence intensity increases obviously at about 392 nm .
Cat. No.: HY-D3094
CAS No.: 2687198-42-9
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TPE-SQ5 is a ratiometric Fluorescent probe for hypochlorite (ClO -) detection with a limit of detection of 5.6 nM. TPE-SQ5 exhibits high selectivity and high sensitivity towards ClO -. TPE-SQ5 can be oxidized by ClO - to form an epoxide, which quenches its deep red fluorescence; subsequently, the epoxide decomposes into a hemicyanine and a sulfonic acid-substituted oxindole, producing blue-green fluorescence to achieve a ratiometric response. TPE-SQ5 can form nanoparticles with Pluronic F-127 via the nanoprecipitation method, and these nanoparticles possess cell permeability. TPE-SQ5 has unique Ex/Em spectra in different solvents and nanoparticle forms, with emission peaks at 643 nm (380 nm excitation, 95% H2O/THF), 631 nm (564 nm excitation, DMSO), 652 nm (536 nm excitation, THF) and 630 nm (524 nm excitation, nanoparticles); the Ex/Em settings used for cell imaging are 488/550-650 nm (red channel) and 405/450-550 nm (green channel) .
Cat. No.: HY-D3133
CAS No.: 2410296-16-9
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HS-CyBz is a Fluorescent probe for H₂S detection, enabling ratiometric optical/photoacoustic dual-modality in/ex vivo imaging. Its detection mechanism relies on nucleophilic substitution of its benzoic ester group by HS⁻, which releases an enolic meso-hydroxyltricarboheptamethine cyanine that then undergoes keto-enol tautomerization to form Cy-ketone; this tautomerization causes distinct shifts in absorption and emission spectra, producing a ratiometric response that reduces interferences from tissue scattering, autofluorescence, and probe concentration. In its initial state, HS-CyBz has an excitation wavelength of 595 nm, with emission bands centered at 805 nm (main) and 630 nm (minor); upon reaction with H₂S, the 805 nm emission band decreases while the 630 nm band drastically increases, and its absorption spectrum shows a sharp band at 775 nm and a shoulder band at 708 nm, which decrease upon H₂S reaction with a minor increase at 850 nm and an isosbestic point at 825 nm. For in vivo optical imaging, excitation at 560 nm is used with emission channels at 620 nm and 790 nm, while in vivo photoacoustic imaging uses excitation at 775 nm and 825 nm. The detection limit of HS-CyBz for H₂S is 0.5 μM, and it shows high selectivity, with only H₂S inducing a distinct enhancement of the emission ratio F₆₃₀/F₈₀₅ and PA ratio PA₈₂₅/PA₇₇₅, while other biochemical species including cations, anions, reactive oxygen species, biothiols, and carboxylesterase trigger only minor changes and do not interfere with H₂S sensing. Tail intravenous injection of HS-CyBz leads to accumulation in the liver of mice, and it can be used to verify endogenous H₂S upregulation triggered by S-adenosyl-L-methionine via ratiometric optical/photoacoustic imaging .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
