Search Result

Results for "

Dnp

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) Amino Acid Derivatives (1) AMPK (1) Amyloid-β (1) Angiotensin-converting Enzyme (ACE) (5) Antibiotic (1) Apoptosis (1) Bacterial (1) Beta-secretase (1) Biochemical Assay Reagents (22) Caspase (5) Cathepsin (5) Cholinesterase (ChE) (1) COX (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (1) Environmental Pollutants (1) Fc Receptor (FcR) (1) FGFR (1) Fluorescent Dye (28) Guanylate Cyclase (1) Hapten (1) HIV Integrase (1) Insecticide (2) Isotope-Labeled Compounds (1) MMP (14) Peptide-Drug Conjugates (PDCs) (1) Phosphoramidites (1) Prostaglandin Receptor (1) PROTAC Linkers (12) Reactive Oxygen Species (ROS) (1) Reference Standards (1) STAT (1) TNF Receptor (1) Transmembrane Glycoprotein (2)
By Research Areas:	Cancer (24) Cardiovascular Disease (3) Infection (6) Inflammation/Immunology (4) Metabolic Disease (10) Neurological Disease (4)
Click Chemistry:	DBCO (2) PROTAC Synthesis (2) Azide (1)
Oligonucleotides:	Fluorescent Lipids (1) Nucleotide Analogs (1) Phospholipids (1) Other Phosphoramidite (1) Phosphoramidites (1)

105

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-DNP159AF

House dust mite extract, from D.pteronyssinus (biotinylated)	Biochemical Assay Reagents	Others
House dust mite extract, from D.pteronyssinus (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .

HY-DNP159F

House dust mite extract, from D.farinae (biotinylated)	Biochemical Assay Reagents	Others
House dust mite extract, from D.farinae (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .

HY-P4931

*Mca-KPLGL-Dap(Dnp)-AR-NH2* 1 Publications Verification	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-P5354

FRETS-VWF73 1 Publications Verification	Fluorescent Dye	Cardiovascular Disease
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). FRETS-VWF73 is a predictive tool for thrombotic thrombocytopenic purpura .

HY-P1883A

*Bacterial Sortase Substrate III, Abz/DNP* TFA**	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP TFA undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P3749

*Mca-(ala7,lys(dnp)9)-bradykinin*	Fluorescent Dye	Others
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .

HY-140614

DNP-PEG4-NHS ester 2 Publications Verification	PROTAC Linkers	Cancer
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-136433

N,N'-Dinitrosopiperazine 1,4-Dinitrosopiperazine; Dnp	Others	Cancer
N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine; DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .

HY-N2252

Licarin A (+)-Licarin A	TNF Receptor Prostaglandin Receptor COX	Neurological Disease Metabolic Disease Inflammation/Immunology
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .

HY-W040024

*Fmoc-Lys(Dnp)-OH*	Amino Acid Derivatives	Others
Fmoc-Lys(Dnp)-OH is a lysine derivative .

HY-P1853

*Abz-FR-K(Dnp)-P-OH*	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Abz-FR-K(Dnp)-P-OH is an angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay .

HY-P2536

*Mca-Ala-Pro-Lys(Dnp)-OH* 2 Publications Verification	Angiotensin-converting Enzyme (ACE)	Others
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-132141

5-PA-dUTP 5-Propargylamino-dUTP	DNA/RNA Synthesis	Others
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5354A

FRETS-VWF73 TFA 1 Publications Verification	Fluorescent Dye	Others
FRETS-VWF73 TFA, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm) .

HY-P4920

*Mca-SEVNLDAEFK(Dnp)-NH2*	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-140619

DNP-PEG4-DBCO	PROTAC Linkers	Cancer
DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-D1050

DNP-X, SE 1 Publications Verification 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester	Fluorescent Dye	Metabolic Disease
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	MMP	Cancer
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-P3792

*Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)*	Biochemical Assay Reagents	Others
Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .

HY-P10172

*Abz-SDK(Dnp)P-OH*	Angiotensin-converting Enzyme (ACE)	Neurological Disease
Abz-SDK(Dnp)P-OH is a fluorescence peptide. Abz-SDK(Dnp)P-OH is the substrate of angiotensin I-converting enzyme (ACE). Abz-SDK(Dnp)P-OH has fluorescent donor-acceptor pair Abz and Dnp (2,4-dinitrophenyl) .

HY-P10173

*Abz-LFK(Dnp)-OH*	Angiotensin-converting Enzyme (ACE)	Others
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .

HY-P10174A

ADAM-17 Substrate TFA	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P1859

*MCA-SEVNLDAEFR-K(Dnp)-RR, amide*	Fluorescent Dye	Others
MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.

HY-P3624

Cenderitide	Guanylate Cyclase	Cardiovascular Disease
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .

HY-140617

DNP-PEG3-azide	PROTAC Linkers	Cancer
DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-P2616A

*Mca-YVADAP-Lys(Dnp)-OH TFA*	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P3120

*Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2*	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-P3123A

Dnp-RPLALWRS TFA	Fluorescent Dye	Others
Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Endogenous Metabolite	Metabolic Disease
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P4931A

*Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA*	Fluorescent Dye	Others
Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .

HY-140618

DNP-PEG4-alcohol	PROTAC Linkers	Cancer
DNP-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-P2616

*Mca-YVADAP-Lys(Dnp)-OH*	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P3477

*Mca-PLA-Nva-Dap(Dnp)-AR-NH2*	Fluorescent Dye	Others
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .

HY-P10870

*Pep1-DNP* conjugate 9**	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P10923

KYS-1	Cathepsin	Others
KYS-1 is a selective substrate for cathepsin E with a K_m value of 1.9 μM. KYS-1 was incubated with cathepsin E (1.0 ng) with the pH optimum of approximately pH 4.0 .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4926

*Mca-SEVKMDAEFRK(Dnp)RR-NH2*	Amyloid-β	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-P10344

*MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2*	Fluorescent Dye	Infection
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro .

HY-130198

DNP-PEG4-acid	PROTAC Linkers	Cancer
DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-P4404

*Abz-GIVRAK(Dnp)*	Cathepsin	Others
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P3098

*Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2*	MMP	Others
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-157182

DNP-PEG2-NHCO-C2-DBCO	Biochemical Assay Reagents	Cancer
DNP-PEG2-NHCO-C2-DBCO is a clickable hapten that bears a dinitrophenyl (DNP) moiety as the antibody‐recruiting motif at one end, a polyethylene glycol chain as a spacer and a dibenzocyclooctene at the other end for the SPAAC chemistry .

HY-P4737

*FITC-YVADAPK(Dnp)*	Fluorescent Dye	Others
FITC-YVADAPK(Dnp) is a fluorogenic substrate .

HY-P4919

*Mca-SEVNLDAEFK(Dnp)*	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-P10452

*Ac-LEVDGWK(Dnp)-NH2*	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .

Cat. No.	Product Name

HY-L157

Animal-Sourced Natural Product Library

995 compounds

Natural product have great diversity and structural complexity of scaffolds. And the number of their drugs represents a large number of sources of new pharmacological entities, so natural products are of great significance in drug discovery. The Dictionary of Natural Products (DNP) shows that natural products mainly come from plants, animals and microorganisms, and animal sources are the second important source of natural products. Animal derived natural products exist to varying degrees in almost all forms of animals, generally secondary metabolite extracted from organisms.

MCE provides a unique collection of 995 animal-sourced natural products. MCE Animal-Sourced Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-P3749

*Mca-(ala7,lys(dnp)9)-bradykinin*	Fluorescent Dye
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .

HY-P2536

*Mca-Ala-Pro-Lys(Dnp)-OH* 2 Publications Verification	Fluorescent Dye
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .

HY-D1050

DNP-X, SE 1 Publications Verification 6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester	Fluorescent Dye
DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester), the DNP-X acid modified by succinimidyl ester, is an amine-reactive building block for developing a probe, which can be recognized by anti-DNP antibodies. DNP-X, SE (6-(2,4-Dinitrophenyl)aminohexanoic acid, succinimidyl ester) is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	Fluorescent Dye
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-P3120

*Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2*	Fluorescent Dye
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-P2616

*Mca-YVADAP-Lys(Dnp)-OH*	Fluorescent Dye
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P2185

NFF-3	Fluorescent Dye
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P3098

*Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2*	Fluorescent Dye
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-D1049

DNP-X acid 6-((2,4-Dinitrophenyl)amino)hexanoic acid	Fluorescent Dye
DNP-X acid (6-((2,4-Dinitrophenyl)amino)hexanoic acid), an amine-reactive building block for developing a probe, can be recognized by anti-DNP antibodies. DNP-X acid is also an excellent amine-reactive FRET quencher paired with Trp or Tyr.

HY-P2614

*Mca-DEVDAP-K(Dnp)-OH*	Fluorescent Dye
Mca-DEVDAP-K(Dnp)-OH is a fluorogenic substrate for caspase-3 .

HY-P3475

*Mca-VDQMDGW-K(Dnp)-NH2*	Fluorescent Dye
Mca-VDQMDGWK-(Dnp)-NH2 is a fluorogenic substrate for caspase-3 and can be used to quantify caspase-3 activity .

HY-124013

NBDA 4-(α-N-L-alanine)-NBD	Fluorescent Dye
NBDA (4-(α-N-L-alanine)-NBD) is a structural and functional analogue of the 2,4-dinitrophenyl group (DNP). NBDA can be used to detect and characterize antinitroaromatic antibodies, even in crude preparations, and possibly on cell surfaces .

HY-P3120A

*Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA*	Fluorescent Dye
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-D3307

Dnp-GPLG	Fluorescent Dye
Dnp-GPLG is a peptide that can be used as a negative control for matrix metalloproteinase (MMP) activity. MMPs can cleave peptides containing the Dnp-GPLG sequence.

HY-D3226

Zinc(II) probe-1

Fluorescent Dye

Zinc (II) probe-1 (Compound DNP) is a dual-color Fluorescent probe that can simultaneously monitor Zn ²⁺ and H ⁺. Upon interaction with Zn ²⁺, Zinc (II) probe-1 produces bright blue fluorescence (excitation wavelength: 405 nm; blue channel wavelength: 420-500 nm). Upon interaction with H ⁺, Zinc (II) probe-1 exhibits red fluorescence (excitation wavelength: 561 nm; red channel emission wavelength: 630-730 nm). Zinc (II) probe-1 can be used in studies related to depression .

Cat. No.	Product Name	Type

HY-DNP159AF

House dust mite extract, from D.pteronyssinus (biotinylated)	Biochemical Assay Reagents
House dust mite extract, from D.pteronyssinus (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .

HY-DNP159F

House dust mite extract, from D.farinae (biotinylated)	Biochemical Assay Reagents
House dust mite extract, from D.farinae (biotinylated), the most common source of indoor allergens, induces a variety of allergic diseases, including allergic rhinitis, conjunctivitis, allergic asthma, and atopic dermatitis .

HY-132141

5-PA-dUTP 5-Propargylamino-dUTP	Biochemical Assay Reagents
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W336372

Dnp-Pro-OH	Biochemical Assay Reagents
Dnp-Pro-OH is a kind of biochemical reagent.

HY-174937

DNP-PEG3-acid Dnp-PEG3-COOH	Biochemical Assay Reagents
DNP-PEG3-acid (DNP-PEG3-COOH) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and propionic acid, which can be used for drug delivery.

HY-174936

DNP-PEG8-COOH Dnp-PEG8-acid	Biochemical Assay Reagents
DNP-PEG8-COOH (DNP-PEG8-acid) is a compound composed of 2,4-dinitroaniline (DNP), three PEG units, and a carboxyl group (-COOH) that can be used for drug delivery.

HY-W190745

DNP-PEG8-NHS ester	Biochemical Assay Reagents
DNP-PEG8-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), eight PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG8-NHS ester can be used for drug delivery.

HY-W190745A

DNP-PEG2-NHS ester	Biochemical Assay Reagents
DNP-PEG2-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), two PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG2-NHS ester can be used for drug delivery.

HY-W190745B

DNP-PEG3-NHS ester	Biochemical Assay Reagents
DNP-PEG3-NHS ester is a PEG derivative that contains DNP (2,4-dinitroaniline), three PEG units, and NHS ester. NHS ester can covalently bind to molecules with amino groups (such as proteins, antibodies, etc.). DNP-PEG3-NHS ester can be used for drug delivery.

HY-W190791

DNP-PEG2-NH2	Biochemical Assay Reagents
DNP-PEG2-NH2 is a PEG derivative that can be used for drug delivery research.

HY-W190756

DNP-PEG3-NH2	Biochemical Assay Reagents
DNP-PEG3-NH2 is a PEG derivative that can be used for drug delivery research.

HY-140617B

DNP-PEG12-azide

Biochemical Assay Reagents

DNP-PEG12-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-140617A

DNP-PEG2-azide

Biochemical Assay Reagents

DNP-PEG2-azide is a PEG derivative that can be used for drug delivery and other research. DNP-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups .

HY-167567

*16:0 DNP* PE** 1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) ammonium	Biochemical Assay Reagents
16:0 DNP PE (1,2-Dihexadecanoyl-sn-glycero-3-phosphoethanolamine-N-(2,4-dinitrophenyl) (ammonium)) is a kind of biochemical reagent.

Cat. No.	Product Name	Target	Research Area

HY-P4931

*Mca-KPLGL-Dap(Dnp)-AR-NH2* 1 Publications Verification	MMP	Cancer
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 (FS-6) is a fluorescent peptide that is a quenched MMP peptide substrate. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 can be used for real-time quantification of MMP enzymatic activity. Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 is an elongated peptide of MMP substrate (FS-1) and is active against collagenases (MMP-1, MMP-8, MMP-13 ) and MT1-MMP with higher specificity constants than FS-1 . (Ex/Em=325 nm/400 nm)

HY-P5354

FRETS-VWF73 1 Publications Verification	Fluorescent Dye	Cardiovascular Disease
FRETS-VWF73, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). FRETS-VWF73 is a predictive tool for thrombotic thrombocytopenic purpura .

HY-P1883A

*Bacterial Sortase Substrate III, Abz/DNP* TFA**	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP TFA is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP TFA undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P3749

*Mca-(ala7,lys(dnp)9)-bradykinin*	Fluorescent Dye	Others
Mca-(ala7,lys(dnp)9)-bradykinin is a sensitive fluorogenic substrate for ECE-1 (endothelin-converting enzyme-1). The incorporation of a (7-methoxycoumarin-4-yl)acetyl (Mca) fluorescent group and a 2,4-dinitrophenyl (Dnp) quenching group has resulted in a large fluorescence increase upon substrate cleavage .

HY-W040024

*Fmoc-Lys(Dnp)-OH*	Amino Acid Derivatives	Others
Fmoc-Lys(Dnp)-OH is a lysine derivative .

HY-P1853

*Abz-FR-K(Dnp)-P-OH*	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Abz-FR-K(Dnp)-P-OH is an angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay .

HY-P2536

*Mca-Ala-Pro-Lys(Dnp)-OH* 2 Publications Verification	Angiotensin-converting Enzyme (ACE)	Others
Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung .

HY-P2185A

NFF-3 TFA	MMP	Others
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P5354A

FRETS-VWF73 TFA 1 Publications Verification	Fluorescent Dye	Others
FRETS-VWF73 TFA, a 73-amino-acid peptide, is a fluorogenic substrate for ADAMTS13 assay (Ex=340 nm; Em=450 nm) .

HY-P4920

*Mca-SEVNLDAEFK(Dnp)-NH2*	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-P3484

Dnp-PLGLWA-DArg-NH2 TFA	MMP	Cancer
Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm) .

HY-P3792

*Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp)*	Biochemical Assay Reagents	Others
Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) is a FRET substrate of Thimet oligopeptidase. Mca-Pro-Leu-Gly-Pro-D-Lys(Dnp) can be used for the determination of Thimet oligopeptidase activity .

HY-P10172

*Abz-SDK(Dnp)P-OH*	Angiotensin-converting Enzyme (ACE)	Neurological Disease
Abz-SDK(Dnp)P-OH is a fluorescence peptide. Abz-SDK(Dnp)P-OH is the substrate of angiotensin I-converting enzyme (ACE). Abz-SDK(Dnp)P-OH has fluorescent donor-acceptor pair Abz and Dnp (2,4-dinitrophenyl) .

HY-P10173

*Abz-LFK(Dnp)-OH*	Angiotensin-converting Enzyme (ACE)	Others
Abz-LFK(Dnp)-OH is an angiotensin I-converting enzyme (ACE) peptide substrate. Abz-LFK(Dnp)-OH is selective for the C domain of ACE. Abz-LFK(Dnp)-OH can be used to assess ACE activity .

HY-P10174A

ADAM-17 Substrate TFA	Fluorescent Dye MMP	Others
ADAM-17 Substrate is a fluorescent substrate of ADAM .

HY-P2498A

Cathepsin D and E FRET Substrate acetate	Cathepsin	Cancer
Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P1859

*MCA-SEVNLDAEFR-K(Dnp)-RR, amide*	Fluorescent Dye	Others
MCA-SEVNLDAEFR-K(Dnp)-RR, amide is a FRET-based substrate.

HY-P3624

Cenderitide	Guanylate Cyclase	Cardiovascular Disease
Cenderitide is a potent agonist of particulate guanylyl cyclase receptor (pGC). Cenderitide is a natriuretic peptide (NP) composed of C-type natriuretic peptide (CNP) fused to the C-terminus of Dendroaspis natriuretic peptide (DNP). Cenderitide activates both pGC-A and pGC-B, activates the second messenger cGMP, suppresses aldosterone, and preserves GFR without reducing blood pressure. Cenderitide can be used for heart failure research .

HY-P5529

*2Abz-GLQRALEI-Lys(Dnp)-NH2*	Peptides	Others
2Abz-GLQRALEI-Lys(Dnp)-NH2 is a biological active peptide. (C4 P4-P4′ substrate)

HY-P2616A

*Mca-YVADAP-Lys(Dnp)-OH TFA*	Cholinesterase (ChE) Caspase	Others
Mca-YVADAP-Lys(Dnp)-OH TFA is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P3120

*Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2*	MMP Fluorescent Dye	Others
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 is a fluorogenic substrate for matrix metalloproteinase-14 (MMP-14). Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2, upon cleavage by MMP-14, releases 7-methoxycoumarin-4-acetyl (Mca) (Ex/Em = 328/420 nm).

HY-P3123A

Dnp-RPLALWRS TFA	Fluorescent Dye	Others
Dnp-RPLALWRS TFA is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS TFA at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS TFA provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Endogenous Metabolite	Metabolic Disease
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-P5419A

WAAG-3R TFA	Biochemical Assay Reagents	Others
WAAG-3R TFA is a biological active peptide. (Aggrecanases belong to the ADAMTS (A disintegrin and metalloprotease with thrombospondin motif) family of proteases. Aggrecanases cleave aggrecan, the major structural component of cartilage. Aggrecanase-1 (ADAMTS-4) is a major aggrecanase in human osteoarthritic cartilage. This FRET peptide was used in an ADAMTS-4 (Aggrecanase-1) and ADAMTS-5 (Aggrecanase-2) assay . (Ex/Em = 340/420 nm)

HY-P1883

Bacterial Sortase Substrate III, Abz/DNP	Fluorescent Dye	Infection
Bacterial Sortase Substrate III, Abz/DNP is a fluorescent peptide substrate. Bacterial Sortase Substrate III, Abz/DNP undergoes cleavage catalyzed by Staphylococcus aureus sortase A (SrtAΔN24) and Streptococcus pyogenes sortase A (SrtAΔN81), and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of the cell wall cross-bridge. Cleavage of this substrate can be detected at Ex/Em=320 nm/420 nm .

HY-P4931A

*Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA*	Fluorescent Dye	Others
Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA is a fluorogenic substrate for matrix metalloproteinases (MMPs). 7-methoxycoumarin-4 acetyl (Mac) is released and its fluorescence can be used to quantify MMP activity. Mac displays Ex/Em of 328/420 nm .

HY-P2689

DNP-PLGMWSR	Peptides	Others
DNP-PLGMWSR is a? fluorogenic substrate for MMP-2 and MMP-9 .

HY-P2616

*Mca-YVADAP-Lys(Dnp)-OH*	Caspase Angiotensin-converting Enzyme (ACE)	Others
Mca-YVADAP-Lys(Dnp)-OH is a fluorogenic substrate for caspase-1 and angiotensin-converting enzyme 2 (ACE2) .

HY-P3477

*Mca-PLA-Nva-Dap(Dnp)-AR-NH2*	Fluorescent Dye	Others
Mca-PLA-Nva-Dap(Dnp)-AR-NH2 is a fluorogenic substrate for matrix metalloproteinase-2 (MMP-2) .

HY-P10870

*Pep1-DNP* conjugate 9**	Peptide-Drug Conjugates (PDCs) FGFR Apoptosis	Cancer
Pep1-DNP conjugate 9 is a functionalized peptide which is composed of the DNP-Hapten and the FGFR1 binding peptide. Pep1-DNP conjugate 9 exhibits good affinity to FGFR1 with K_D of 5.01 μM. Pep1-DNP conjugate 9 recruits anti-DNP antibodies to the surface of FGFR1-positive cells, inhibits the FGF2-induced proliferation in rat skeletal myoblast cells, and induces apoptosis. Pep1-DNP conjugate 9 exhibits antitumor efficacy in mouse models .

HY-P2185

NFF-3	MMP	Others
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocyte growth factor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .

HY-P10923

KYS-1	Cathepsin	Others
KYS-1 is a selective substrate for cathepsin E with a K_m value of 1.9 μM. KYS-1 was incubated with cathepsin E (1.0 ng) with the pH optimum of approximately pH 4.0 .

HY-P2498

Cathepsin D and E FRET Substrate	Cathepsin	Others
Cathepsin D and E FRET Substrate is a fluorogenic substrate for cathepsins D and E and not for B, H or L. The cleavage occurs at the Phe-Phe amide bond resul. Cathepsin D and E FRET Substrate is a valuable tool for routine assays and for mechanistic studies on cathepsins E and D .

HY-P4926

*Mca-SEVKMDAEFRK(Dnp)RR-NH2*	Amyloid-β	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-P10344

*MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2*	Fluorescent Dye	Infection
MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 is a fluorescent substrate used for fluorescence resonance energy transfer (FRET) protease assays. This substrate is employed to measure the activity of SARS-CoV-2 3CLpro .

HY-P4404

*Abz-GIVRAK(Dnp)*	Cathepsin	Others
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal .

HY-P3098

*Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2*	MMP	Others
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-26. Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 can be used to quantify MMP-1, MMP-3 and MMP-26 activity .

HY-P4737

*FITC-YVADAPK(Dnp)*	Fluorescent Dye	Others
FITC-YVADAPK(Dnp) is a fluorogenic substrate .

HY-P4919

*Mca-SEVNLDAEFK(Dnp)*	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-P10452

*Ac-LEVDGWK(Dnp)-NH2*	Caspase	Others
Ac-LEVDGWK(Dnp)-NH2 is a substrate for Caspase-3, and can be used to detect Caspase-3 activity .

HY-P5528

*2Abz-SLGRKIQIK(Dnp)-NH2*	Peptides	Others
2Abz-SLGRKIQIK(Dnp)-NH2 is a biological active peptide. (This peptide is a second complement component (C2), the physiological substrate for the proenzyme Cls, first complement component. The complement system is a central component of host defense but can also contribute to the inflammation seen in pathological conditions. The C1s protease of the C1 complex initiates the host defense pathway. This peptide employs 2Abz/Dnp FRET pair for quantitation of complement enzyme activity.)

HY-P5530

*2Abz-SVARTLLV-Lys(Dnp)-NH2*	Peptides	Others
2Abz-SVARTLLV-Lys(Dnp)-NH2 is a biological active peptide. (C1-inhibitor P4-P4′ substrate)

HY-P2716

*Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2*	MMP	Others
Mca-Arg-Pro-Lys-Pro-Tyr-Ala-Nva-Trp-Met-Lys(Dnp)-NH2 is a biological active peptide. (MMP substrate)

HY-P5996

*MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2*	Fluorescent Dye	Others
MCA-Gly-Asp-Ala-Glu-pTyr-Ala-Ala-Lys(DNP)-Arg-NH2 is a protein tyrosine phosphatase fluorogenic substrate that can be detected at 393 nm (with excitation at 325 nm) .

HY-P2089

Dnp-PYAYWMR	MMP	Others
Dnp-PYAYWMR is a peptide substrate that selectively targets MMP3. Dnp-PYAYWMR is cleaved by MMP3 to produce Dnp-PYA (nonfluorescent) and YWMR (fluorophore detectable at 360 nm). After incubation of MMP3 with Dnp-PYAYWMR for 2 h, MMP3 fluorescence intensity was measured. Ex/Em=328/350 nm .

HY-P3123

Dnp-RPLALWRS	Fluorescent Dye	Others
Dnp-RPLALWRS is a fluorescent peptide substrate designed for human matrilysin (MMP-7). After enzymatic cleavage of Dnp-RPLALWRS at the alanine-leucine bond, the release of the Dnp group alleviates fluorescence quenching, thereby enabling real-time quantitative analysis of MMP-7 activity by increasing tryptophan emission. Dnp-RPLALWRS provides a sensitive and efficient detection method for kinetic studies and inhibitor screenin .

HY-P4227A

*WRVYEKC(dnp)ALK tetraTFA*	Peptides	Metabolic Disease
WRVYEKC(dnp)ALK tetraTFA contains tryptophan that can be liberated from the dinitrophenol (DNP) quencher by aminopeptidase activity. WRVYEKC(dnp)ALK tetraTFA can be used as a hydrolysis reaction decapeptide substrate .

HY-P4905

*Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2*	MMP	Cancer
Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 is highly selective substrate for matrix metalloproteases 12 (MMP12) substrate with a kcat/Km value of 1.8510 ⁵ M ^-1s ^-1, and poor substrate of other MMPs with the exception of MMP13* (kcat/Km = 0.5310 ⁵ M ^-1s ^-1) and MMP9* (0.33*10 ⁵ M ^-1s ^-1) .

HY-P10139

Dnp-PLGLWAr-NH2	MMP	Others
Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples .

HY-P3476

*Mca-VDQVDGW-Lys(Dnp)-NH2*	Fluorescent Dye Caspase	Cancer
Mca-VDQVDGW-Lys(Dnp)-NH2 is a fluorogenic substrate of caspase-7. Mca-VDQVDGW-K(Dnp)-NH2 can be used to quantify caspase-7 activity.

Cat. No.	Product Name	Target	Research Area	Image

HY-P992344

DNP002	Transmembrane Glycoprotein	Cancer
DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001) .

HY-P992058

Leukotuximab ART-140; Dnp-001; EGX-040	Transmembrane Glycoprotein	Cancer
Leukotuximab (ART-140; EGX-040) is an anti-JL1 mAb and an anti-leukemic agent. Leukotuximab targets the JL1 epitope of CD43 and exerts cytotoxic effects on JL1-positive leukemia cells. Except for thymocytes and some bone marrow mononuclear cells, Leukotuximab causes no damage to most normal tissues. Leukotuximab can be used in the research of acute myeloid leukemia, acute lymphoblastic leukemia, and myelodysplastic syndrome .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2252

Licarin A (+)-Licarin A	Monophenols Saururaceae Neurological Disease Classification of Application Fields Simple Phenylpropanols Saururus chinensis (Lour.) Baill. Phenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields Source Classification	TNF Receptor Prostaglandin Receptor COX
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .

HY-N6711

Equisetin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	HIV Integrase Bacterial Antibiotic Reactive Oxygen Species (ROS) STAT AMPK 11β-HSD
Equisetin is an N-methylserine-derived acyl tetramic acid, quorum sensing inhibitor (QSI), herbicides and antibiotics. Equisetin specifically inhibits the anionic carriers of substrates in the inner mitochondrial membrane. Equisetin inhibits the activity of HIV-1 integrase, 11β-HSD1, and 2,4-dinitrophenol (Dnp)-stimulated ATPase (IC₅₀ = ~8 nmol per mg of protein). Equisetin exhibits growth inhibition of bacteria, anti-inflammatory, amelioration of lipid-associated disorders, and cytotoxic effects .

HY-137330

S-(2,4-Dinitrophenyl)glutathione	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an K_i value of 30 µM .

HY-N15882

*16:0 DNP* Cap PE monoammonium**	Lipid	Biochemical Assay Reagents
16:0 DNP Cap PE monoammonium is an antigenic lipid that plays a role in promoting antigen presentation on lipid bilayers .

HY-N15876

*18:1-6:0 DNP-C11 BODIPY 505/515 TG*	Lipid	Fluorescent Dye
18:1-6:0 DNP-C11 BODIPY 505/515 TG is a fluorescently-labeled triglyceride that can be used to study the effects of phosphoinositides (Ex/Em = 495/503 nm) .

HY-N11725

Phlorofucofuroeckol A	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Fc Receptor (FcR)
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .

Cat. No.	Product Name	Chemical Structure

HY-136433S

N,N'-Dinitrosopiperazine-d8
N,N'-Dinitrosopiperazine-d₈ is the deuterium labeled N,N'-Dinitrosopiperazine . N,N'-Dinitrosopiperazine (1,4-Dinitrosopiperazine;DNP) is a carcinogen with specificity for nasopharyngeal epithelium and facilitates NPC metastasis. N,N'-Dinitrosopiperazine regulates multiple signaling pathways through protein phosphorylation, including LYRIC at serine 568 .

Cat. No.	Product Name		Classification

HY-140619

DNP-PEG4-DBCO		DBCO PROTAC Synthesis
DNP-PEG4-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-140617

DNP-PEG3-azide		PROTAC Synthesis Azide
DNP-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DNP-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-157182

DNP-PEG2-NHCO-C2-DBCO		DBCO
DNP-PEG2-NHCO-C2-DBCO is a clickable hapten that bears a dinitrophenyl (DNP) moiety as the antibody‐recruiting motif at one end, a polyethylene glycol chain as a spacer and a dibenzocyclooctene at the other end for the SPAAC chemistry .

Cat. No.	Product Name		Classification

HY-162543

18:1 Liss Rhod PE 18:1 Lissamine rhodamine PE		Phospholipids
18:1 Liss Rhod (18:1 Lissamine rhodamine) PE is a fluorescent phospholipid and fluorescent probe.18:1 Liss Rhod PE admixes into phospholipid inks for large-scale monitoring of dip-pen nanolithography-generated lithographic structures via fluorescence microscopy.18:1 Liss Rhod PE undergoes phase separation or self-quenching under certain conditions in thin lipid membrane stacks .

HY-132141

5-PA-dUTP 5-Propargylamino-dUTP		Nucleotide Analogs
5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery . 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-177237

Dnp-Teg Cep		Phosphoramidites Other Phosphoramidite
Dnp-Teg Cep is a phosphoramidite that can be used in the synthesis of oligonucleotides.

HY-179761

*16:0 C4-BODIPY 505/515 DNP* Cap PE ammonium**		Fluorescent Lipids
16:0 C4-BODIPY 505/515 DNP Cap PE ammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

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Dnp

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Screening Libraries

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