Search Result

Results for "

Euphorbia

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Apoptosis (5) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (1) Caspase (2) CDK (1) Collagen (1) Drug Derivative (3) Endogenous Metabolite (3) ERK (1) Fungal (1) Glutaminase (1) Herbicide (1) HIV (2) IAP (2) JAK (2) MAGL (2) NF-κB (2) OAT (1) P-glycoprotein (1) Parasite (2) PKC (3) Reference Standards (3) RSV (1) Src (1) TGF-beta/Smad (2) TRP Channel (1) VEGFR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (1) Endocrinology (1) Infection (7) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2333

Resiniferatoxin Maximum Cited Publications 10 Publications Verification (+)-Resiniferatoxin	TRP Channel	Cardiovascular Disease Cancer
Resiniferatoxin ((+)-Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period .

HY-B0719

Ingenol Mebutate 5 Publications Verification Ingenol 3-angelate; PEP005	PKC	Inflammation/Immunology Cancer
Ingenol Mebutate is an active ingredient in Euphorbia peplus, acts as a potent PKC modulator, with K_is of 0.3, 0.105, 0.162, 0.376, and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε, respectively, and has antiinflammatory and antitumor activity.

HY-N0732

Jolkinolide B 1 Publications Verification	IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3 and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis .

HY-N0866

20-Deoxyingenol 5 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-N0313

Euphol	MAGL Endogenous Metabolite	Inflammation/Immunology
Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC₅₀=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N5001

Euphorbia Factor L2	Apoptosis	Cancer
Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed (the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. Euphorbia factor L2 shows potent cytotoxicity and induces apoptosis via a mitochondrial pathway .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N0562

5,15-Diacetyl-3-benzoyllathyrol Euphorbia factor L3	Others	Cancer
5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

HY-137242

Ingenol-3-palmitate	HIV	Infection
Ingenol-3-palmitate, an ingenane diterpenoid, is a nature product that could be isolated from the roots of Euphorbia ebracteolata. Ingenol-3-palmitate is a potent HIV-1 (HIV) inhibitor with an IC₅₀ value of 4.1 nM .

HY-N1969

3,3'-Di-O-methylellagic acid 3,8-Di-O-methylellagic acid	Bacterial	Infection
3,3'-Di-O-methylellagic acid obtained from Euphorbia adenochlora selectively inhibits the formation of acid-fastness in mycobacteria without retardation of their growth. 3,3'-di-O-methylellagic acid as a hepatoprotective compound is apparently due to its antioxidative effect .

HY-N12730

Euphoscopin B	Others	Others
Euphoscopin B (compound 5) is a cytotoxic macrocyclic diterpene isolated from Euphorbia helioscopia L .

HY-W123056

Candelilla wax Euphorbia CERIFERA (CANDELILLA) WAX	Biochemical Assay Reagents	Others
Candelilla wax is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N7267

31-Norlanostenol	Others	Endocrinology
31-Norlanostenol is a triterpenic compound isolated from the latex of Euphorbia officinarum. 31-Norlanostenol can act as efficient insect growth regulator on S. frugiperda and Tenebrio molitor .

HY-N8560

3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one	Others	Others
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a Diterpenoids product that can be isolated from the roots of Euphorbia kansui. .

HY-N10990

Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate	Others	Others
Ingol 7,8,12-triacetate 3-(4-methoxyphenyl)acetate is a highly functionalized ingol diterpene that can be isolated from Euphorbia officinarum latex .

HY-133209

Fischeria A	Others	Cancer
Fischeria A is a norditerpene lactone of a new carbon skeleton, can be isolated from Euphorbia fischeriana .

HY-119767

Jolkinolide A	VEGFR Apoptosis	Cancer
Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells .

HY-N0313R

Euphol (Standard)	MAGL Endogenous Metabolite Reference Standards	Inflammation/Immunology
Euphol (Standard) is the analytical standard of Euphol. This product is intended for research and analytical applications. Euphol is a tetracyclic triterpene alcohol isolated from the sap of Euphorbia tirucalli with anti-mutagenic, anti-inflammatory and immunomodulatory effects, orally active. Euphol inhibits the monoacylglycerol lipase (MGL) activity via a reversible mechanism (IC50=315 nM). MGL inhibition in the periphery modulates the endocannabinoid system to block the development of inflammatory pain .

HY-N8118

Euphorbia factor L7b	Others	Others
Euphorbia factor L7b is an isolathyrolditerpene compound .

HY-N7332

Pepluanin A	P-glycoprotein	Cancer
Pepluanin A is a natural compound isolated from Euphorbia peplus L. Pepluanin A shows a very high activity for a jatrophane diterpene, outperforming Cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated Daunomycin (HY-13062A) transport ^[1]

HY-N16121

12-Deoxyphorbol 13-isobutyrate	PKC	Neurological Disease
12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research .

HY-N7893

Ebracteolata cpd B	Others	Others
Ebracteolata cpd B is a natural phenol compound found in Euphorbia ebracteolata .

HY-125114

Jatrophane 4	Endogenous Metabolite	Others
Jatrophane 4 is a secondary metabolite of Euphorbia peplus. Jatrophane 4 is a diterpene .

HY-N11269

Epi-β-amyrin	Drug Derivative	Others
Epi-β-amyrin is a chemical component that can be extracted from Euphorbia pulcherrima. Epi-β-amyrin is a steroid compound .

HY-125648

Euphorbadienol alpha-Euphorbol	Parasite	Infection
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-N9280

ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide	Others	Others
ent-11α-Hydroxyabieta-8(14),13(15)-dien-16,12α-olide (compound 12) is a natural bioactive diterpenoid found in the roots of Euphorbia fischeriana .

HY-W744699

Larixol (+)-Larixol	Src ERK Akt	Inflammation/Immunology
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-N8119

Euphorbia factor L8	Others	Others
Euphorbia factor L(8) is a diterpenoid from the seeds of Euphorbia lathyris .

HY-N8121

Euphorbia factor L7a	Others	Others
Euphorbia factor L7a, a diterpenoid compound, can be isolated from the seeds of Euphorbia lathyris .

HY-N10875

Euphebracteolatin B	Others	Others
Euphebracteolatin B is a nature product that could be isolated from Euphorbia fischeriana .

HY-N1645

2,16-Kauranediol Kaurane-2β,16-diol	Others	Others
2,16-Kauranediol, a diterpene compound, is a natural product that can be isolated from the aerial part of Euphorbia hirta .

HY-138142

Euphol acetate	OAT	Metabolic Disease
Euphol acetate is a triterpene that can be isolated from Euphorbia broteri. Euphol acetate is an inhibitor of hepatic transport proteins organic anion-transporting polypeptide 1/3 (OATP1B1/3) .

HY-N7464

Jolkinolide E	Others	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N10839

Yuexiandajisu E	Others	Cancer
Yuexiandajisu E is a diterpenoid that can be found in Euphorbia ebracteolata .

HY-N9207

Germanicol acetate	Others	Others
Germanicol acetate can be extracted from Euphorbia heterophylla L. and has phytotoxic activity .

HY-N0868

20-O-Acetylingenol-3-angelate Euphorbia factor Pe1	Others	Others
20-O-Acetylingenol-3-angelate is a natural compound.

HY-N7304

Jatrophane I	Others	Others
Jatrophane I is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .

HY-N7306

Jatrophane VI	Others	Others
Jatrophane VI is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .

HY-N11060

(Rac)-Dehydrovomifoliol PBI 344	Others	Others
(Rac)-Dehydrovomifoliol (PBI 344) is a bisnorsesquiterpene compound that can be found in Euphorbia peplus .

HY-N8959

9-O-Ethyldeacetylorientalide	Others	Others
9-O-Ethyldeacetylorientalide is a Sesquiterpenoids product that can be isolated from the herbs of Euphorbia pekinensis .

HY-N11025

Kansenone	Others	Others
Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui .

HY-N7823

Phorbol 13-acetate	Others	Others
Phorbol 13-acetate is a Diterpenoids product that can be isolated from the roots of Euphorbia pekinensis Rupr. .

HY-137037

Ingenol 20-palmitate	HIV	Cancer
Ingenol 20-palmitate (compound 2) is a diterpene that can be found in Euphorbia lath yris .

HY-N8555

ent-Kaurane-16β,19,20-triol	Others	Others
ent-Kaurane-16β,19,20-triol is a Diterpenoids product that can be isolated from the herbs of Euphorbia ehracteolata .

HY-N1596

Ent-16α,17-dihydroxykauran-3-one Ent-3-oxokaurane-16α,17-diol	Others	Others
Ent-16α,17-dihydroxykauran-3-one is a diterpenoid, which can be isolated from the roots of Euphorbia ebracteolata .

HY-N12434

Euphorblin R EOF2	Others	Metabolic Disease
Euphorblin R (EOF2) is a rhamnyl diterpenoid isolated from Euphorbia resinifera. Euphorblin R may promote lysosomal biogenesis and has the potential to be used in the study of lysosome-related diseases.

HY-N9189

5,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane	Others	Others
5,8,9,14-Tetraacetoxy-3-benzoyloxy-10,15-dihydroxypepluane is a Diterpenoids product that can be isolated from the herbs of Euphorbia peplus .

HY-N3970

Gopherenediol	Others	Neurological Disease
Gopherenediol is a diterpenoid with putative antifeedant activity against Mammalian herbivores. Gopherenediol is the active compound in to form deterrent effect, protects gopherweed, Euphorbia lathyris (Euphorbiaceae) from feeding by Mammalian herbivores .

HY-N13116

3-O-(2",3"-Dimethylbutanoyl)-13-O-decanoylingenol	Parasite	Others
3-O-(2",3"-Dimethylbutanoyl)-13-O-decanoylingenol (compound 2) is a diterpenoid with antinematode activity, which can be isolated from Euphorbia kansui .

HY-N11027

5-O-Benzoyl-20-deoxyingenol	Others	Others
5-O-Benzoyl-20-deoxyingenol is a diterpene that can be isolated from the roots of Euphorbia kansui. 5-O-Benzoyl-20-deoxyingenol inhibits cell proliferation .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Euphorbia

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
Products