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Results for "

FGF19

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Derivative (1) FGFR (2) mRNA (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (3) Inflammation/Immunology (1) Metabolic Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS04895

FGF19 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
FGF19 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

FGF19 Human Pre-designed siRNA Set A FGF19 Human Pre-designed siRNA Set A

HY-RS23234

Fgf19 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Fgf19 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgf19 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Fgf19 Rat Pre-designed siRNA Set A Fgf19 Rat Pre-designed siRNA Set A

HY-147515

FGFR4-IN-11	FGFR	Cancer
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC₅₀ of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity .

HY-174703

*Human FGF19* mRNA**	mRNA	Cancer
Human FGF19 mRNA encodes the human fibroblast growth factor 19 (FGF19) protein, a member of the fibroblast growth factor (FGF) family. FGF19 probably involves in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades.

HY-179381

FGFR4-IN-24	FGFR	Cancer
FGFR4-IN-24 is a selective irreversible covalent FGFR4 inhibitor (IC₅₀ = 1.2 nM). FGFR4-IN-24 shows much weaker activity against the other three FGFR family kinases (FGFR1-3). FGFR4-IN-24 inhibits the FGF19/FGFR4 signaling pathway, effectively suppressing the proliferation of the HuH-7 HCC cell line (GI₅₀ = 17 nM). FGFR4-IN-24 exhibits significant antitumor activity in a HuH-7 mouse xenograft model. FGFR4-IN-24 can be used for the research of hepatocellular carcinoma .

HY-176961

Homocholic acid	Drug Derivative	Metabolic Disease
Homocholic acid is a synthetic steroid analogue. Homocholic acid can be labeled with 75Se and is used for SeHCAT detection (a method for diagnosing bile acid malabsorption) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990414

*Anti-FGF19* Antibody (1A6)**	Inhibitory Antibodies	Inflammation/Immunology
Anti-FGF19 Antibody (1A6) is a CHO-expressed humanized antibody that targets *FGF19. Anti-FGF19* Antibody (1A6) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-FGF19 Antibody (1A6) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Recombinant Proteins Recommended:

FGF-19

Species:	Human (5) Mouse (1)
Tag:	SUMO (1) His (3) Tag Free (1) Fc (1) Flag (1)
Source:	HEK293 (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7172

	FGF-19 Protein, Human rHuFGF-19; FGF19	Human	E. coli
	FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.

HY-P70583

	FGF-19 Protein, Human (His) Fibroblast growth factor 19; FGF-19; FGF19	Human	E. coli
	FGF-19 protein plays a crucial role in regulating bile acid biosynthesis by inhibiting CYP7A1 expression through positive regulation of JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes, dependent on KLB and FGFR4. FGF-19 Protein, Human (His) is the recombinant human-derived FGF-19 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7172A

	FGF-19 Protein, Human (HEK293, Flag) rHuFGF-19; FGF19	Human	HEK293
	FGF-19 Protein, Human could activate a physiologically important, insulin-independent endocrine pathway that regulates hepatic protein and glycogen metabolism.

HY-P70583AF

	*Animal-Free FGF-19* Protein, Human (His)** Fibroblast growth factor 19; FGF-19; FGF19	Human	E. coli
	FGF-19 protein plays a crucial role in regulating bile acid biosynthesis by inhibiting CYP7A1 expression through positive regulation of JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes, dependent on KLB and FGFR4. Animal-Free FGF-19 Protein, Human (His) is the recombinant human-derived animal-FreeFGF-19 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P704607

	FGF-19 Protein, Human (HEK293, Fc) rHuFGF-19; FGF19	Human	HEK293
	FGF-19 protein plays a crucial role in regulating bile acid biosynthesis by inhibiting CYP7A1 expression through positive regulation of JNK and ERK1/2 cascades. It stimulates glucose uptake in adipocytes, dependent on KLB and FGFR4. FGF-19 Protein, Human (HEK293, Fc) is the recombinant human-derived FGF-19 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P71526

	FGF-15 Protein, Mouse (His-SUMO) 1 Publications Verification FGF-15; FGF15; FGF15_MOUSE; FGF19; Fibroblast growth factor 15	Mouse	E. coli
	FGF-15 Protein crucially suppresses bile acid biosynthesis by down-regulating CYP7A1 expression, contributing to intricate bile acid homeostasis control. Interacting with MALRD1 suggests potential involvement in molecular pathways beyond bile acid regulation. The molecular associations and regulatory functions underscore FGF-15's significance in maintaining physiological balance, particularly in bile acid metabolism. FGF-15 Protein, Mouse (His-SUMO) is the recombinant mouse-derived FGF-15 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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HY-P82927

	FGF19 Antibody (YA2672) FGF19; Fibroblast growth factor 19	WB	Human
	FGF19 Antibody (YA2672) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FGF19.

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Cat. No.	Product Name		Classification

HY-RS04895

FGF19 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
FGF19 Human Pre-designed siRNA Set A contains three designed siRNAs for FGF19 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23234

Fgf19 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Fgf19 Rat Pre-designed siRNA Set A contains three designed siRNAs for Fgf19 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174703

*Human FGF19* mRNA**		mRNA
Human FGF19 mRNA encodes the human fibroblast growth factor 19 (FGF19) protein, a member of the fibroblast growth factor (FGF) family. FGF19 probably involves in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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