FGFR4-IN-11
FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2396664-85-8
- 分子式: C29H29N5O5
- 分子量:527.57
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
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FGFR4 2.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | IC50 |
26 nM
Compound: 30
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Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
Inhibition of cell proliferation in human Huh-7 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
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[PMID: 35549181] |
| MDA-MB-453 | IC50 |
6.3 nM
Compound: 30
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Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
Inhibition of cell proliferation in human MDA-MB-453 cells incubated for 72 hrs by Cell Titer-Glo luminescent assay
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[PMID: 35549181] |
化学情報
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CAS 番号 2396664-85-8
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分子量 527.57
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分子式 C29H29N5O5
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SMILES
COC1=CC(C(C2=CNC3=NC(NC4=C(C=C(C=C4)N5CCOCC5)NC(C=C)=O)=CC=C32)=O)=CC(OC)=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FGFR4-IN-11 関連分類
HY-147515 関連分類
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