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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
GPR109B
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "GPR109B" in MCE Product Catalog:
1
Research Areas:
Acifran (AY 25712) is an orally active, full GPR109A and GPR109B agonist and hypolipidemic agent. Acifran reduces Forskolin (HY-15371)-induced cAMP elevation, triggers ERK1/ERK2 phosphorylation, and inhibits lipolysis in adipose tissue through Gi-coupled GPCR activation. Acifran is used for research on atherosclerosis, hyperlipidemia, and type 2 diabetes .
Cat. No.: HY-W014502
CAS No.: 13441-51-5
Category:
Microorganisms Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields
Target:
Target:
Research Areas:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GPR109 receptor agonist-1 is a highly selective agonist of the human orphan G protein-coupled receptor GPR109b, and does not activate the mouse homologous receptor PUMA-G. GPR109 receptor agonist-1 functionally modulates the human GPR109b receptor via the cAMP signaling pathway, with an EC50 of 400 nM. GPR109 receptor agonist-1 inhibits isoproterenol (HY-B0468)-stimulated lipolysis in human subcutaneous adipocytes, with efficacy comparable to that of Niacin (HY-B0143), and does not act on β-adrenergic receptors. GPR109 receptor agonist-1 can be used in studies related to dyslipidemia and atherosclerosis .
Cat. No.: HY-47823
CAS No.: 291528-35-3
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GPCR agonist-2 (Compound 5j) is a GPCR GPR109b (HM74) agonist, with a pEC50 value of 6.51. GPCR agonist-2 can be used for research of lipid disorders .
Cat. No.: HY-W014502R
CAS No.: 13441-51-5
Cat. No.: HY-107579R
CAS No.: 72420-38-3
Synonyms: AY 25712 (Standard)
Target:
Cat. No.: HY-187109
CAS No.: 960060-89-3
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Research Areas:
6-(Cyclobutylamino)-3-pyridinecarboxylic acid is a highly selective GPR109b agonist (pEC50 = 7.14) that reverses the Forskolin (HY-15371)-induced elevation of cAMP in stably transfected mammalian cells. 6-(Cyclobutylamino)-3-pyridinecarboxylic acid can be used for the research of dyslipidemia .
Cat. No.: HY-189101
CAS No.: 853260-98-7
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GPR109 receptor agonist-4 is a high-affinity GPR109a and low-affinity GPR109b niacin receptor agonist with EC50 values of 24 μM and 4.8 μM, respectively. GPR109 receptor agonist-4 acts through Gi-coupled receptors to reduce intracellular cAMP, which in turn negatively regulates hormone-sensitive lipase activity and inhibits lipolysis. GPR109 receptor agonist-4 can be used in the study of atherosclerosis .
Cat. No.: HY-RS06041
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HCAR3 Human Pre-designed siRNA Set A contains three designed siRNAs for HCAR3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06039
Target:
Research Areas:
Hcar2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Hcar2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS06040
Target:
Research Areas:
Hcar2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Hcar2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
