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![(2S,2'S)-2,2'-(1,3,6,8-Tetraoxobenzo[lmn][3,8]phenanthroline-2,7(1H,3H,6H,8H)-diyl)dipropanoic acid](https://file.medchemexpress.com/product_pic/hy-w456337.gif "Click to View (2S,2'S)-2,2'-(1,3,6,8-Tetraoxobenzo[lmn][3,8]phenanthroline-2,7(1H,3H,6H,8H)-diyl)dipropanoic acid Product Detail")
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
H8
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "H8" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N2411
CAS No.: 60314-89-8
Target:
1
Research Areas:
H-8 dihydrochloride is a selective Cyclic nucleotide-dependent protein kinase inhibitor. H-8 dihydrochloride potently inhibits cGMP- and cAMP-dependent protein phosphorylation. H-8 dihydrochloride enhances the vasodilatory effect induced by 8-bromo-cAMP (HY-12306A). H-8 dihydrochloride fails to attenuate the vasodilatory effects induced by 8-bromo-cGMP (HY-101379A), atrial natriuretic peptide II, or Sodium nitroprusside (HY-B0564) in rat aorta .
Cat. No.: HY-P99620
CAS No.: 1443004-15-6
Synonyms: CT-P22; CT120
Target:
Research Areas:
Cat. No.: HY-117093
CAS No.: 423731-10-6
H8-A5 is a novel human histone deacetylase 8 (HDAC8) inhibitor. A highly specific ZBG-based pharmacophore model was developed by incorporating a custom zinc-binding group (ZBG) feature. Pharmacophore-based virtual screening identified three novel HDAC8 inhibitors with low micromolar IC50 values (1.8-1.9 μM). Further studies showed that H8-A5 was more selective for HDAC8 than HDAC1/4 and exhibited antiproliferative activity in MDA-MB-231 cancer cells. Molecular docking and molecular dynamics studies showed that H8-A5 could bind to HDAC8, providing a good starting point for the development of HDAC8 inhibitors for cancer treatment.
Cat. No.: HY-RS15996
Target:
Research Areas:
ZC3H8 Human Pre-designed siRNA Set A contains three designed siRNAs for ZC3H8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-164123
CAS No.: 2001602-07-7
Antibiofilm agent-9 (Compound 4) is a pyrrolomycin derivative with antibacterial activity. Antibiofilm agent-9 inhibits Bacillus anthracis with MIC of 0.031 μg/mL. Antibiofilm agent-9 exhibits antibiofilm activity with 84% biofilm inhibition (24 h, 8.0 μg/mL). Antibiofilm agent-9 exhibits a good pharmacokinetic characters in mouse model .
Cat. No.: HY-N16910
CAS No.: 61755-75-7
Target:
Cat. No.: HY-W456337
CAS No.: 429692-85-3
(2S,2'S)-2,2'-(1,3,6,8-Tetraoxobenzo[lmn][3,8]phenanthroline-2,7(1H,3H,6H,8H)-diyl)dipropanoic acid is a metal-organic framework (MOF).
Cat. No.: HY-P77033
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Influenza A H8N4 (A/pintail duck/Alberta/114/1979) Hemagglutinin / HA Protein (His)
Species:
Source:
Cat. No.: HY-P88967A
Synonyms: Fliz1; ZC3HDC8
Cat. No.: HY-180922
CAS No.: 3081622-35-4
EGFR kinase-IN-8 (Compound H8b) is an EGFR inhibitor. EGFR kinase-IN-8 potently inhibits both triple-mutated EGFR L858R/T790M/C797S (IC50 = 3.86 nM) and double-mutated EGFR L858R/T790M (IC50 = 1.23 nM). EGFR kinase-IN-8 suppresses EGFR phosphorylation and downstream AKT, STAT3, and MAPK signaling. EGFR kinase-IN-8 exhibits anticancer activity against non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
