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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
HPR
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "HPR" in MCE Product Catalog:
11
11 Cited Publications
Synonyms: 4-HPR; ISLA-101
Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
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Art. -Nr.: HY-109583
CAS. Nr.: 865536-65-8
Synonyms: 4-Oxo-4-HPR
Forschungsgebiete:
4-Oxofenretinide (4-Oxo-4-HPR) is a metabolite of Fenretinide (HY-15373). 4-Oxofenretinide induces cell growth inhibition in ovarian, breast, and neuroblastoma tumor cell lines. 4-Oxofenretinide causes a marked accumulation of cells in G2-M. 4-Oxofenretinide induces cancer cell apoptosis through caspase-9 .
Art. -Nr.: HY-106827
CAS. Nr.: 74513-62-5
Synonyms: RU 27987
Forschungsgebiete:
Trimegestone (RU 27987) is an orally active, selective progestogen and PR ligand, with an IC50 of 7.6 nM for hPR, 4.4 nM for rabbit PR, and 3.3 nM for rat PR. Trimegestone induces Alkaline phosphatase activity. Trimegestone exhibits antiandrogenic activity (IC50 = 303 nM). Trimegestone can be used in research related to menopausal symptoms and osteoporosis .
Art. -Nr.: HY-W442049
CAS. Nr.: 893412-73-2
Synonyms: HPR
Target:
Forschungsgebiete:
Hydroxypinacolone retinoate (HPR) is a direct-binding agonist of retinoic acid receptor (RAR). Hydroxypinacolone retinoate has low irritation and high stability; when formulated into nanoparticles, its transdermal efficiency is enhanced, allowing it to penetrate deep into the dermis and achieve sustained release. When used in combination with Retinyl propionate, hydroxypinacolone retinoate promotes fibroblast proliferation and upregulates the gene expression of type IV collagen, CRBP-I and RARB. Hydroxypinacolone retinoate can be used in research related to skin wrinkles and skin aging .
Art. -Nr.: HY-RS06343
Target:
Forschungsgebiete:
HPR Human Pre-designed siRNA Set A contains three designed siRNAs for HPR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-15373R
CAS. Nr.: 65646-68-6
Synonyms: 4-HPR (Standard); ISLA-101 (Standard)
Target:
Forschungsgebiete:
Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.
Art. -Nr.: HY-109583S
CAS. Nr.: 2991099-34-2
Synonyms: 4-Oxo-4-HPR-d4
Art. -Nr.: HY-167638
CAS. Nr.: 79982-82-4
Synonyms: 4-HPR-O-glucuronide
Target:
Forschungsgebiete:
Fenretinide glucuronide (4-HPR-O-glucuronide) is a metabolite formed from Fenretinide (HY-15373) through glucuronidation. The formation of Fenretinide glucuronide enhances the water solubility of Fenretinide and facilitates its excretion. Fenretinide glucuronide holds potential for research in the field of cancer .
Art. -Nr.: HY-143957S
CAS. Nr.: 2118244-60-1
Synonyms: 4-HPR-O-glucuronide-d4
Art. -Nr.: HY-189117
CAS. Nr.: 36857-46-2
Target:
Forschungsgebiete:
HPR-611 is a Tiaramide (HY-W838171) derivative. HPR-611 inhibits the release of histamine, i-LTB4, and i-LTC4 in rat peritoneal exudate cells, guinea pig lung fragments, and human lung fragments. HPR-611 can be used for research on bronchial asthma .
Art. -Nr.: HY-189035
CAS. Nr.: 157254-42-7
Target:
Forschungsgebiete:
1,3-PBITU is an eNOS inhibitor (Ki = 9 μM) that inhibits NO Synthase. 1,3-PBITU reduces venular hydraulic conductivity in the frog mesenteric venule model. 1,3-PBITU blocks apoptosis induced by 4‑HPR and by 4‑HPR combined with Trastuzumab (HY-P9907) in HER2-overexpressing breast cancer cells, demonstrating that NO is an essential mediator of this apoptotic pathway. 1,3-PBITU can be used in research related to NOS-mediated diseases .
Art. -Nr.: HY-183518
CAS. Nr.: 179894-84-9
Forschungsgebiete:
LG-120753 is an orally active nonsteroidal progesterone receptor (PR) antagonist, with an IC50 of 38 nM against hPR-B, a Ki of 19 nM against hPR-A, an IC50 of 227 nM against hAR, and IC50 values greater than 1000 nM against hGR, hER and hMR. LG-120753 blocks the action of progesterone, binds to and antagonizes hPR-A, and shows limited cross-reactivity with other steroid receptors. LG-120753 blocks blastocyst implantation, prevents the establishment of pregnancy, exhibits dose-dependent antiprogestogenic activity in vivo, and induces reversible antifertility effects .
Art. -Nr.: HY-119080
CAS. Nr.: 532435-68-0
Target:
Forschungsgebiete:
CP8754 is an orally active, selective human progesterone receptor (hPR) antagonist that blocks progesterone-mediated signaling pathways. CP8754 competitively inhibits the binding of [ 3H]-progesterone to hPR. And in vitro, CP8754 inhibits progesterone-dependent exogenous luciferase and endogenous alkaline phosphatase expression; while in vivo, CP8754 inhibits rabbit endometrial transformation. CP8754 does not significantly bind to human glucocorticoid receptors (hGR), estrogen receptors (hER), or rat androgen receptors (rAR). CP8754 can be used in the study of progesterone-related diseases such as breast cancer, endometriosis, uterine fibroids, and meningioma, as well as hormone-dependent tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
