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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
HSV-2 replication
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "HSV-2 replication" in MCE Product Catalog:
1
PFM067 (DMHCA) is an orally active cholestenoic acid amide derivative. PFM067 exhibits antiviral activity against HSV‑2, HSV‑1, and HRV‑A1. PFM067 directly binds the ORD domain of human OSBP with a Kd of 3.96 μM. PFM067 blocks late HSV-2 replication, cell-to-cell fusion, syncytium formation, and infectious progeny production, retains glycoproteins in the cis-Golgi, and may block capsid nuclear egress. PFM067 agonizes LXRβ and inhibits DHCR24, restoring membrane fluidity in diabetic CD34 + cells and CAC cells. PFM067 protects retinal vascular/visual function in diabetic mice. PFM067 can be used in research related to herpesvirus infection and type 2 diabetes .
1
Cosalane (NSC 658586) is a CCR7 (IC50 = 2.43 μM) and CXCR2 antagonist (IC50 = 0.66 μM). Cosalane is an inhibitor of HIV replication with a wide range of activity against HIV-1 isolates, HIV-2, Rauscher murine leukemia virus, HSV-1, HSV-2 and human cytomegalovirus. Cosalane inhibits both attachment of gp120 to CD4. Cosalane inhibits human and murine CCR7 in response to both CCL19 and CCL21 agonists. Cosalane can be studied in research for HIV or attenuating acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (HSCT) .
1
1 Cited Publications
Cat. No.: HY-U00124B
CAS No.: 41544-24-5
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .
Synonyms: FIAU; DRG-0098; NSC 678514
Fialuridine (FIAU), a nucleoside analog, is a HSV-1 and HSV-2 inhibitor with Kis of 0.14 μM and 0.95 μM, respectively. Fialuridine shows anti-orthopoxvirus and anti-hepatitis B virus (HBV) activities. Fialuridine inhibits duck HBV DNA replication with IC50 values of 0.075 μM and 156 μM in human hepatoma cells and in chicken liver cells, respectively .
Cat. No.: HY-18944
CAS No.: 1113044-49-7
Target:
연구분야:
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
Cat. No.: HY-170547
CAS No.: 2701561-91-1
Target:
연구분야:
DNA polymerase-IN-6 is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 can be used in research related to viral infections .
Cat. No.: HY-U00124
CAS No.: 53783-83-8
Tromantadine hydrochloride, an Amantadine derivative with antiherpetic activity, inhibits herpes simplex virus type 1 (HSV-1) and HSV-2 replication .
Cat. No.: HY-174252
CAS No.: 3016396-78-1
Target:
연구분야:
HSV-1/HSV-2-IN-3 inhibits the herpes-simplex-virus (HSV) helicase-primase complex, blocking the coordinated DNA-unwinding and primer-synthesis steps required for viral genome replication. HSV-1/HSV-2-IN-3 exhibits an EC50 of 7.0 nM against HSV-2 in a gD-immunofluorescence cell assay containing 2 % FBS and 57.5 nM when 10 % human serum is present. HSV-1/HSV-2-IN-3 achieves an EC50 of 1.1 nM in a qPCR replication assay. HSV-1/HSV-2-IN-3 shows strong selectivity over human carbonic-anhydrase off-targets (IC50 ≈ 2.9 µM for hCA II and > 35 µM for hCA I). HSV-1/HSV-2-IN-3 can be studied in anti-HSV research .
Cat. No.: HY-18944R
CAS No.: 1113044-49-7
Target:
연구분야:
FIT-039 (Standard) is the analytical standard of FIT-039. This product is intended for research and analytical applications. FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
Cat. No.: HY-163546
CAS No.: 3044784-31-5
HSV-1-IN-1 (compound 1b) is a drug candidate for herpes simplex virus HSV-1(IC50=0.5 nM) and HSV-2(IC50=16 nM) infection. HSV-1-IN-1 inhibits the helicase-primase complex to prevent viral replication, thereby inhibiting HSV infection .
Cat. No.: HY-190480
CAS No.: 241139-69-5
PFM067-N-morpholine is an OSBP inhibitor that binds to the ORD domain of the host lipid transfer protein, which is involved in HSV-2 replication. PFM067-N-morpholine has a Kd of 4.93 μM for human OSBP. PFM067-N-morpholine inhibits HSV-2 replication with a selectivity index, with an EC50 of 8 nM in Hela cells. PFM067-N-morpholine can be used for research on HSV-2 infection .
Cat. No.: HY-N19905
CAS No.: 53060-72-3
Cat. No.: HY-170547A
Target:
연구분야:
DNA polymerase-IN-6 formic is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 formic inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 formic exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 formic can be used in research related to viral infections .
Cat. No.: HY-N21911
CAS No.: 115166-32-0
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
