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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
IDO-IN-1
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "IDO-IN-1" in MCE Product Catalog:
Cat. No.: HY-79531
CAS No.: 914638-30-5
Research Areas:
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.
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Research Areas:
Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor .
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11 Cited Publications
Cat. No.: HY-N0110
CAS No.: 10605-02-4
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Research Areas:
LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1 .
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Research Areas:
PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively [1] .
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Research Areas:
BMS-978587 (IDO-IN-4) is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor, extracted from patent WO2014150677A1, Compound example 1 enantiomer 1.
Research Areas:
TDO-IN-1 is an orally active and selective inhibitor of tryptophan 2,3-dioxygenase (TDO), shows excellent selectivity over indoleamine-2,3-dioxygenase (IDO), with an IC50 value of 0.62 μM (IDO). TDO-IN-1 reverse the local immune tolerance of tumor tissue to inhibit tumor growth in vivo [1].
Synonyms: cis-10-Pentadecenoic acid
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology
10(Z)-Pentadecenoic acid (cis-10-Pentadecenoic acid) is a monounsaturated fatty acid with Z configuration. 10(Z)-Pentadecenoic acid is degraded via two pathways, reductase-isomerase and epimerase. 10(Z)-Pentadecenoic acid is one of the major monounsaturated FAME components evaluated as biodiesel feedstock in Chlorella sp. RCS2. 10(Z)-Pentadecenoic acid weakly inhibits IFN-γ-induced IDO-1 activity and kynurenine production. 10(Z)-Pentadecenoic acid is a non-esterified fatty acid downregulated in adolescent depression and has diagnostic discriminatory potential. 10(Z)-Pentadecenoic acid is used in studies related to depression, inflammation, and lipid metabolism [1] .
Research Areas:
IDO1/2-IN-1 (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 exhibits antitumor activies. Orally active [1].
Research Areas:
Necrostatin-1 (Standard) is the analytical standard of Necrostatin-1. This product is intended for research and analytical applications. Necrostatin-1 (Nec-1) is a potent and cross the blood-brain barrier necroptosis inhibitor with an EC50 of 490 nM in Jurkat cells. Necrostatin-1 inhibits RIP1 kinase (EC50=182 nM). Necrostatin-1 is also an IDO inhibitor .
Cat. No.: HY-145280A
CAS No.: 2310286-60-1
Research Areas:
IDO1/2-IN-1 hydrochloride (compound 4t) is the first potent IDO1/IDO2 dual inhibitor with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively. IDO1/2-IN-1 hydrochloride exhibits antitumor activies. Orally active [1].
Cat. No.: HY-N0110R
CAS No.: 10605-02-4
Cat. No.: HY-160025
CAS No.: 2206797-88-6
Research Areas:
IDO antagonist-1 (compound 163) is an antagonist of IDO . IDO antagonist-1 inhibits pancreatic adenocarcinoma cells growth in C57BL/6 mice [1].
Cat. No.: HY-W834359
CAS No.: 219783-00-3
Research Areas:
(±)-Longamide is a polycyclic bioactive metabolite isolated from sponges that has several bromopyrrole fragments, as well as a weak inhibitor of IDO1 .
Cat. No.: HY-173067
CAS No.: 3048196-74-0
Research Areas:
IDO1 ligand-1 is the target protein ligand of PROTAC NU227326 (HY-173066). NU227326 can be used to degrade IDO1 .
Cat. No.: HY-180770
CAS No.: 958733-17-0
Category:
Carica papaya L. Caricaceae Extract Ketones, Aldehydes, Acids Plants Endogenous metabolite
Target:
Cat. No.: HY-111540R
CAS No.: 2166616-75-5
Synonyms: IDO1-IN-5 (Standard)
Research Areas:
LY-3381916 (Standard) is the analytical standard of LY-3381916 (HY-111540). This product is intended for research and analytical applications. LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacKing heme rather than mature heme-bound IDO1 .
Cat. No.: HY-101111R
CAS No.: 198474-05-4
Synonyms: EOS200271 (Standard)
Research Areas:
PF-06840003 (Standard) is the analytical standard of PF-06840003 (HY-101111). This product is intended for research and analytical applications. PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 μM, 0.59 μM, and 1.5 μM for hIDO-1, dIDO-1, and mIDO-1, respectively [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
