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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
ILK
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "ILK" in MCE Product Catalog:
12
12 Publications Verification
Referencia número: HY-18676
No. CAS: 2070015-22-2
OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain) . OSU-T315 abrogates AKT activation by impeding AKT localization in lipid rafts and triggers caspase-dependent apoptosis in an ILK-independent manner . OSU-T315 causes cell death through apoptosis and autophagy .
2
2 Cited Publications
Target:
Áreas de investigación:
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
The product specifications provided below refer solely to the active content of 12-HETE.
The product specifications provided below refer solely to the active content of 12-HETE.
2
2 Cited Publications
Target:
Áreas de investigación:
12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway .12-HETE has both anti-thrombotic and pro-thrombotic effects . 12-HETE is a neuromodulator .
The product specifications provided below refer solely to the active content of 12-HETE-d8.
The product specifications provided below refer solely to the active content of 12-HETE-d8.
Referencia número: HY-18676B
No. CAS: 1333146-24-9
Synonyms: OSU-T315 analog
ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models .
Referencia número: HY-P4866
No. CAS: 1361235-89-3
Áreas de investigación:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Referencia número: HY-RS06787
Target:
Áreas de investigación:
ILK Human Pre-designed siRNA Set A contains three designed siRNAs for ILK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS23195
Target:
Áreas de investigación:
Ilk Rat Pre-designed siRNA Set A contains three designed siRNAs for Ilk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-177912
No. CAS: 1333146-87-4
Target:
Áreas de investigación:
ILK-IN-4 (compound 49) is an integrin-linked kinase (ILK) inhibitor. ILK-IN-4 can be used for cancer research .
Referencia número: HY-RS16756
Target:
Áreas de investigación:
Ilk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ilk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-184113
Synonyms: DHP
Target:
Áreas de investigación:
Dihydropelitinib (DHP) is a ILK ligand with a Kd value of 252 nM. Dihydropelitinib acts as a cytoskeleton modulator that induces actin (Actin) cytoskeleton rearrangement. Dihydropelitinib exhibits anticancer activity against liver cancer and lung adenocarcinoma. Dihydropelitinib can be used in studies related to liver cancer and lung adenocarcinoma .
Referencia número: HY-P76438
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ILKAP; ILKAP2; ILK Associated Serine/Threonine Phosphatase; ILKAP3; Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2C; Truncated Integrin-Linked Kinase-Associated Serine/Threonine Phosphatase 2C; PPM1O; Integrin-Linked Kinase-Associated Se
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
