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Results for "

KARS

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Inhibitory Antibodies

1

Natural
Products

1

Recombinant Proteins

2

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W451275
    HG106
    2 Publications Verification

    		 Apoptosis Cancer
    HG106 is an effective SLC7A11 inhibitor. HG106 mediates apoptosis by increasing oxidative stress and endoplasmic reticulum stress, and it has antitumor activity .
    HG106
  • HY-101124
    Rodatristat ethyl

    KAR5585

    		 Tryptophan Hydroxylase 5-HT Receptor Cardiovascular Disease
    Rodatristat ethyl (KAR5585) is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH) .
    Rodatristat ethyl
  • HY-129086
    BPAM344

    		iGluR Neurological Disease
    BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM) .
    BPAM344
  • HY-120083
    Rodatristat

    KAR5417

    		 5-HT Receptor Tryptophan Hydroxylase Cardiovascular Disease
    Rodatristat (KAR5417) is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice .
    Rodatristat
  • HY-168432
    KK181N1

    		Phytohormone Others
    KK181N1 is a potent inhibitor of karrikin (KAR) receptor KAI2. KK181N1 binds to the catalytic pockets of KAI2 in a non-covalent binding manner. KK181N1 selectively depress the KAR-induced phenotypes in Arabidopsis .
    KK181N1
  • HY-RS07071
    KARS1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    KARS1 Human Pre-designed siRNA Set A contains three designed siRNAs for KARS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    KARS1 Human Pre-designed siRNA Set A
    KARS1 Human Pre-designed siRNA Set A
  • HY-P991156
    Rapaprutug

    		Ras Inflammation/Immunology
    Rapaprutug is a monoclonal antibody targeting human KARS1 (lysyl-tRNA synthetase 1). Rapaprutug blocks the relevant inflammatory signaling pathways in which KARS1 is involved, reducing the production and release of inflammatory factors. Rapaprutug is promising for research of inflammatory diseases .
    Rapaprutug
  • HY-116552
    KAR425

    		Parasite Infection
    KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC50 values of 62 nM, 55 nM, and 60 nM, respectively .
    KAR425
  • HY-N2369B
    (-)-Chelidonine

    		Others Others
    (-)-Chelidonine is a Alkaloids product that can be isolated from the herbs of Glaucium squamigerum KAR. et KIR. .
    (-)-Chelidonine
  • HY-180562
    KARS-IN-1

    		Ras Cancer
    KARS-IN-1 (152) is a AKR1C3 dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. KARS-IN-1 shows anti-proliferative activity in H460 (NRF2 pathway mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild type cell line with low AKR1C3 expression), with AC50 values ??of 21 nM and 16 nM, respectively. KARS-IN-1 can be used for the study of non-small cell lung cancer (NSCLC) .
    KARS-IN-1
  • HY-117759
    Deacetoxyvinzolidine

    KAR-2

    		 Microtubule/Tubulin Cancer
    Deacetoxyvinzolidine (KAR-2) is a bis-indol derivative with high anti-microtubular and anti-tumour activities. Deacetoxyvinzolidine exhibits high affinity for bovine purified brain tubulin (Kd of 3 μM) and inhibits microtubule assembly at a concentration of 10 nM. Deacetoxyvinzolidine does not possess anti-calmodulin activity. Deacetoxyvinzolidine can be used for the study of leukaemia .
    Deacetoxyvinzolidine
  • HY-119781
    Kaitocephalin

    PF1191

    		 iGluR Neurological Disease
    Kaitocephalin (PF1191) is an ionotropic glutamate receptor (NMDAR) antagonist with Ki values of 7.8, 590, and 14000 nM for NMDAR, AMPAR, and KAR, respectively. Kaitocephalin protects neurons by inhibiting excitotoxicity, exhibiting neuroprotective effects. Kaitocephalin can be used in research on neurological diseases such as Alzheimer's disease .
    Kaitocephalin

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