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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Legumain
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Legumain" in MCE Product Catalog:
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8 Publications Verification
RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .
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3 Cited Publications
Synonyms: Cbz-Ala-Ala-Asn-AMC
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2 Cited Publications
Legumain inhibitor 1 is a potent and selective Legumain inhibitor with an IC50 of 3.6 nM. Legumain inhibitor 1 can be used for cancer research .
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1 Cited Publications
Cat. No.: HY-P70897A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Legumain; Asparaginyl Endopeptidase; Protease Cysteine 1; LGMN; PRSC1
Cat. No.: HY-176806
CAS No.: 606967-53-7
Synonyms: Doxorubicin-LNAA-Boc
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Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC) .
Cat. No.: HY-149102
CAS No.: 1416080-97-1
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LE 28 is a selective and activity-dependent legumain probe. LE 28 becomes fluorescent only upon binding active legumain. LE 28 can be used for research of cancers and inflammatory diseases .
Cat. No.: HY-176869
CAS No.: 1431625-66-9
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EMC-AANL-DOX is a legumain-activated prodrug conjugate of Doxorubicin (DOX) (HY-15142A). EMC-AANL-DOX shows antitumor activity in mouse models of neuroblastoma (NB), breast cancer (4T1), fibrosarcoma (HT1080), and colorectal cancer liver metastases (CT26). EMC-AANL-DOX can be used for cancer research .
Cat. No.: HY-150242A
Purity: 99.54%
Cbz-Ala-Ala-Asn TFA is a peptide that designed based on the sequence of the substrate of legumain. Legumain is a cysteine protease. Cbz-Ala-Ala-Asn TFA can be applied as a scaffold for drug delivery .
Cat. No.: HY-155486
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HCy-AAN-Bio is a tumor-targeted hemicyanine (HCy) probe for Fluorescent/photoacoustic (FL/PA) imaging of legumain in vivo. Legumain can specifically cleave HCy-AAN-Bio with the generation of FL/PA signal. HCy-AAN-Bio is a powerful tool for early diagnosis of associated cancer .
Cat. No.: HY-183119
CAS No.: 1609690-02-9
Legumain-IN-2 is a selective legumain inhibitor with a human legumain IC50 of 0.9 nM. Legumain-IN-2 can be used for the research of breast cancer .
Cat. No.: HY-P4427
CAS No.: 245036-58-2
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Cat. No.: HY-P703851
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: Legumain; Asparaginyl endopeptidase; AEP; Protease; cysteine 1; LGMN
Cat. No.: HY-P70216A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: rMuLegumain/Asparaginyl Endopeptidase, His; Legumain; Lgmn; Asparaginyl endopeptidase; Protease cysteine 1; Prsc1
Cat. No.: HY-185461
CAS No.: 3108288-42-9
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Mc-Asn-Asn-E104 is a conjugate of E104 (HY-156174) and a legumain-cleavable linker, can be used for the synthesis of E104 ISACs.
Cat. No.: HY-185462
CAS No.: 3059867-76-1
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Mc-Asn-Asn is a legumain cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Asn-Asn can be used in the synthesis of ADCs.
Cat. No.: HY-181958
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mAb-AsnAsn-E104 is a conjugate of an ADC drug toxin molecule and a linker, which contains a degradable PEG linker and the toxin molecule E104 (HY-156174) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
