MADCAM1

By Targets:	Integrin (6) L-Selectin (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P990203

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) 1 Publications Verification	Integrin	Inflammation/Immunology
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis ^[1] .

HY-P99411

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease ^[1].

HY-P990197

*Anti-Mouse MAdCAM-1* Antibody (MECA-367)**	L-Selectin	Metabolic Disease Inflammation/Immunology
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse *MAdCAM-1* IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes ^[1] .

HY-RS25581

Madcam1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Madcam1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Madcam1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Madcam1 Rat Pre-designed siRNA Set A Madcam1 Rat Pre-designed siRNA Set A

HY-RS07952

MADCAM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MADCAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for MADCAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MADCAM1 Human Pre-designed siRNA Set A MADCAM1 Human Pre-designed siRNA Set A

HY-RS19091

Madcam1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Madcam1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Madcam1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Madcam1 Mouse Pre-designed siRNA Set A Madcam1 Mouse Pre-designed siRNA Set A

HY-P991807

*Anti-Mouse MAdCAM-1* Antibody (MECA-89)**	Integrin	Inflammation/Immunology
Anti-Mouse MAdCAM-1 Antibody (MECA-89) reacts with mouse MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-89) blocks the interaction of MAdCAM-1 with its receptor in vivo and in vitro. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) ^[1].

HY-177961

α4β7 Integrin-IN-1	Integrin	Inflammation/Immunology
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of α4β7 integrin (integrin). Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC₅₀) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease ^[1].

HY-159179

α4 integrin receptor antagonist 3	Integrin	Inflammation/Immunology
α4 integrin receptor antagonist 3 (Compound 11) is an orally active α₄integrin receptor antagonist. α4 integrin receptor antagonist 3 can inhibit the adhesion of K562 cells mediated by the interaction between *α₄β₁/VCAM-1* and *α₄β₇/MAdCAM-1, with IC₅₀* values of 130 nM and 2 nM, respectively. α4 integrin receptor antagonist 3 has the potential to be used in the study of dextran sulfate sodium (DSS) colitis mouse model ^[1].

HY-171216

GW559090	Integrin	Neurological Disease
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a K_d of 0.19 nM for *α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC₅₀* values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC₅₀ = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye ^[1].

Cat. No.	Product Name	Target	Research Area	Image

HY-P990203

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) 1 Publications Verification	Integrin	Inflammation/Immunology
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis ^[1] .

HY-P99411

Ontamalimab SHP647	Integrin	Inflammation/Immunology
Ontamalimab (SHP647) is a fully-human IgG2 monoclonal antibody targeting mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Ontamalimab can be used for the research of Crohn's disease ^[1].

HY-P990197

*Anti-Mouse MAdCAM-1* Antibody (MECA-367)**	L-Selectin	Metabolic Disease Inflammation/Immunology
Anti-Mouse MAdCAM-1 Antibody (MECA-367) is an anti-mouse *MAdCAM-1* IgG2a monoclonal antibody. Anti-Mouse MAdCAM-1 Antibody (MECA-367) significantly inhibits the migration of pig peripheral blood lymphocytes (PBL) by blocking the function of MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-367) selectively inhibits B cell migration to exacerbate inflammation. Anti-Mouse MAdCAM-1 Antibody (MECA-367) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as colitis and diabetes ^[1] .

HY-P991807

*Anti-Mouse MAdCAM-1* Antibody (MECA-89)**	Integrin	Inflammation/Immunology
Anti-Mouse MAdCAM-1 Antibody (MECA-89) reacts with mouse MAdCAM-1. Anti-Mouse MAdCAM-1 Antibody (MECA-89) blocks the interaction of MAdCAM-1 with its receptor in vivo and in vitro. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) ^[1].

Recombinant Proteins Recommended:

MAdCAM-1

Species:	Human (6) Mouse (2) Cynomolgus (1)
Tag:	His (7) Avi (4) Myc (1) Fc (2)
Source:	HEK293 (8) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77748

	MAdCAM1 Protein, Mouse (HEK293, His) MADCAM-1; MADCAM1; MACAM1	Mouse	HEK293
	MAdCAM1 is expressed in mucosal venules and serves as a key cell adhesion leukocyte receptor that guides the influx of lymphocytes into mucosal tissues. It regulates leukocyte passage and retention, effectively binding to integrins α-4/β-7 and L-selectin to achieve comprehensive leukocyte adhesion control. MAdCAM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MAdCAM1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P705263

	MAdCAM1 Protein, Mouse (Biotinylated, HEK293, His-Avi) MADCAM-1; MADCAM1; MACAM1	Mouse	HEK293

HY-P70852

	MAdCAM1 Protein, Human (HEK293, His) hMADCAM-1; MACAM1; MADCAM1; MADCAM-1; mucosal addressin cell adhesion molecule 1	Human	HEK293
	MAdCAM1 Protein is an important cell adhesion molecule and a member of the immunoglobulin superfamily. MAdCAM1 Protein plays a key role in immune system cell migration and mucosal immune responses. MAdCAM1 Protein, Human (HEK293, His) is a recombinant MAdCAM1 protein expressed by HEK293, with a C-6*His tag and glycosylation modification.

HY-P704773

	MAdCAM1 Protein, Human (HEK293, Fc) hMADCAM-1; MACAM1; MADCAM1; MADCAM-1; mucosal addressin cell adhesion molecule 1	Human	HEK293
	MAdCAM1 is a cell adhesion leukocyte receptor expressed primarily by mucosal venules and plays a critical role in coordinating lymphocyte trafficking into mucosal tissues, particularly Peyer's patches and intestinal lamina propria. This protein exhibits the ability to bind integrins α-4/β-7 and L-selectin, thereby regulating the passage and retention of leukocytes in the mucosal environment. MAdCAM1 Protein, Human (HEK293, Fc) is the recombinant human-derived MAdCAM1 protein, expressed by HEK293, with C-hFc labeled tag and with N-terminal M.

HY-P705058

	MAdCAM1 Protein, Human (Biotinylated, HEK293, Fc-Avi) hMADCAM-1; MACAM1; MADCAM1; MADCAM-1; mucosal addressin cell adhesion molecule 1	Human	HEK293

HY-P705198

	MAdCAM1 Protein, Cynomolgus (Biotinylated, HEK293, His-Avi) hMADCAM-1; MACAM1; MADCAM1; MADCAM-1; mucosal addressin cell adhesion molecule 1	Cynomolgus	HEK293

HY-P72397

	MAdCAM1 Protein, Human (Biotinylated, HEK293, Avi-His) hMADCAM-1; MACAM1; MADCAM1; MADCAM-1; mucosal addressin cell adhesion molecule 1	Human	HEK293
	MAdCAM1 is a cell adhesion leukocyte receptor expressed primarily by mucosal venules and plays a critical role in coordinating lymphocyte trafficking into mucosal tissues, particularly Peyer's patches and intestinal lamina propria. This protein exhibits the ability to bind integrins α-4/β-7 and L-selectin, thereby regulating the passage and retention of leukocytes in the mucosal environment. MAdCAM1 Protein, Human (Biotinylated, HEK293, Avi-His) is the recombinant human-derived MAdCAM1 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P71818

	MAdCAM1 Protein, Human (P.pastoris, His-Myc) Addressin mucosal; hMADCAM 1 ; hMADCAM-1; MACAM1	Human	P. pastoris
	MAdCAM1 is a cell adhesion leukocyte receptor expressed primarily by mucosal venules and plays a critical role in coordinating lymphocyte trafficking into mucosal tissues, particularly Peyer's patches and intestinal lamina propria. This protein exhibits the ability to bind integrins α-4/β-7 and L-selectin, thereby regulating the passage and retention of leukocytes in the mucosal environment. MAdCAM1 Protein, Human (P.pastoris, His-Myc) is the recombinant human-derived MAdCAM1 protein, expressed by P. pastoris , with C-His, C-Myc labeled tag.

HY-P704774

	MAdCAM1 Protein, Human (299a.a, HEK293, His) Addressin mucosal; hMADCAM 1 ; hMADCAM-1; MACAM1	Human	HEK293
	MAdCAM1 is a cell adhesion leukocyte receptor expressed primarily by mucosal venules and plays a critical role in coordinating lymphocyte trafficking into mucosal tissues, particularly Peyer's patches and intestinal lamina propria. This protein exhibits the ability to bind integrins α-4/β-7 and L-selectin, thereby regulating the passage and retention of leukocytes in the mucosal environment. MAdCAM1 Protein, Human (299a.a, HEK293, His) is the recombinant human-derived MAdCAM1 protein, expressed by HEK293, with C-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82999

	MADCAM1 Antibody (YA2744) MACAM1; MADCAM1	WB	Human
	MADCAM1 Antibody (YA2744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MADCAM1.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS25581

Madcam1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Madcam1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Madcam1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07952

MADCAM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MADCAM1 Human Pre-designed siRNA Set A contains three designed siRNAs for MADCAM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19091

Madcam1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Madcam1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Madcam1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Name
Email *

	Sorry, but the email address you supplied was invalid.