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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
124 Results for "
Ma
" in MedChemExpress (MCE) Product Catalog:
Products (124)
124 Results for "Ma" in MCE Product Catalog:
1354
Target:
114
114 Cited Publications
Synonyms: BIBW 2992Ma2
Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFR wt, EGFR L858R, EGFR L858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer .
5
Research Areas:
Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
2
2 Cited Publications
Cat. No.: HY-P71076
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: S100A8; MRP-8; Prev. CAGA; Urinary Stone Protein Band A; Prev. CFAG; Protein S100-A8; MRP8; Calgranulin A; P8; S100 Calcium-Binding Protein A8; Migration Inhibitory Factor-Related Protein 8; Calgranulin-A; Leukocyte L1 Complex Light Chain; CP-10; Calprotectin L1L Subunit; Ma387; Cystic Fibrosis Antigen; L1Ag; S100-A8; NIF; 60B8AG; S100 Calcium Binding Protein A8; CGLA; S100A9; 60B8AG; Prev. CAGB; CGLB; Prev. CFAG; MIF; MRP-14; NIF; MRP14; Protein S100-A9; P14; Calgranulin B; Migration Inhibitory Factor-Related Protein 14; S100 Calcium-Binding Protein A9 (Calgranulin B); Leukocyte L1 Complex Heavy Chain; S100 Calcium-Binding Protein A9; Calprotectin L1H Subunit; Calgranulin-B; S100-A9; L1AG; MaC387; S100 Calcium Binding Protein A9; LIAG
Species:
Human
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-112816
CAS No.: 1049704-18-8
MA242 is a specific dual inhibitor of MDM2 and NFAT1. MA242 directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 induces apoptosis in pancreatic cancer cell lines regardless of p53 status .
1
1 Cited Publications
Cat. No.: HY-172158
CAS No.: 140481-05-6
Research Areas:
ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m 6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia .
Cat. No.: HY-163385
Target:
Research Areas:
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA .
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JZP-MA-11 is a brain-penetrant positron emission tomography (PET) ligand targeting the brain endocannabinoid α/β-hydrolase domain 6 (ABHD6) enzyme. JZP-MA-11 selectively inhibits ABHD6 with an IC50 value of 126 nM. [18F]JZP-MA-11 has the potential for preclinical evaluation targeting the brain ABHD6 in mice and nonhuman primate (NHP) .
Cat. No.: HY-W105423
CAS No.: 38862-25-8
Synonyms: NHS-Ma
Cat. No.: HY-17631A
CAS No.: 519187-97-4
Synonyms: T-817 Maleate; T-817Ma
Target:
Research Areas:
Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ).
Cat. No.: HY-157465
Purity: 99.84%
Target:
Research Areas:
MA-PEG4-VC-PAB-DMEA-duocarmycin DM is a drug-linker conjugate for ADC by using the DNA minor-groove alkylator Duocarmycin DM (HY-130978), linked via MA-PEG4-vc-PAB-DMEA (HY-126668).
Synonyms: ASP0367; Ma-0211
Target:
Research Areas:
Bocidelpar (ASP0367; MA-0211) is a selective, orally active PPARδ modulator. Bocidelpar activates the PPARδ downstream signaling pathway, upregulates the expression of target genes such as ABCA1 and ACAA2. Bocidelpar then promotes fatty acid oxidation (FAO) and mitochondrial biogenesis, and improves mitochondrial dysfunction. Bocidelpar can improve mitochondrial biogenesis and function in muscle cells. Bocidelpar is mainly used in the study of mitochondrial dysfunction diseases such as primary mitochondrial myopathy (PMM) and Duchenne muscular dystrophy (DMD) .
Cat. No.: HY-160207
CAS No.: 2156649-32-8
Synonyms: Ma-JD21; ABX-002
Research Areas:
Elunetirom (MA-JD21) is an orally active, blood-brain barrier-permeable prodrug of LL-340001. Elunetirom employs fatty acid amide hydrolase (FAAH)-dependent prodrug technology to enhance the brain delivery of LL-340001, a potent thyroid hormone receptor agonist with 15-fold higher selectivity for TRβ over TRα. Elunetirom induces T3-regulated gene expression, including that of ABCD2. Elunetirom drives neuroplasticity and bioenergetic changes, and induces neurogenesis, neuritogenesis, and synaptogenesis. Elunetirom is applicable to research related to major depressive disorder and X-linked adrenoleukodystrophy .
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MA-2029 is a selective, orally active, and competitive motilin receptor antagonist (IC50=4.9 nM). MA-2029 is selective for the motilin receptor over various other receptors and ion channels. MA-2029 may be useful for gastrointestinal disorders associated with disturbed gastrointestinal motility .
Cat. No.: HY-N15643
CAS No.: 23040-84-8
Synonyms: α-Ma (C80)
Category:
Target:
Cat. No.: HY-158998
Purity: 99.16%
Target:
Research Areas:
ALKBH1-IN-2 (Compound 16) is a derivative of ALKBH1-IN-1 (HY-163385). ALKBH1-IN-2 is an ALKBH1 inhibitor. ALKBH1-IN-2 can modulate the 6mA levels .
Cat. No.: HY-158225
Synonyms: Col1Ma
Application: cell culture, biological 3D printing, tissue engineering, etc.
Cat. No.: HY-164190
Target:
Research Areas:
m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium is a Biotin-labled cap analogue that can be used for mRNA synthesis. The efficiency of mRNA delivery can be determined by the detection of Biotin by flow cytometry, which can be used to track mRNA in cells and in living animals and to screen delivery lipid ratios.
Cat. No.: HY-19312S
CAS No.: 110953-39-4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
