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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
354 Results for "
NMR
" in MedChemExpress (MCE) Product Catalog:
Products (354)
354 Results for "NMR" in MCE Product Catalog:
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Dodecylphosphocholine is a detergent widely utilized in NMR studies of membrane proteins .
Cat. No.: HY-P3566
CAS No.: 494750-52-6
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4-Methylbenzyl cyanide is an organic chemical probe used to study intramolecular rotation properties. 4-Methylbenzyl cyanide is promising for research of NMR spectroscopy and physical chemistry research on molecular dynamics .
Cat. No.: HY-W002068
CAS No.: 1583-58-0
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2,4-Difluorobenzoic acid is a difluorinated aromatic carboxylic acid. 2,4-Difluorobenzoic acid can serve as a crystalline molecular ruler for fluorine-fluorine distance measurements by 19F MAS NMR, as well as a non-radioactive passive water tracer for oilfield applications .
Cat. No.: HY-D1640
CAS No.: 152290-47-6
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5,5'-Difluoro BAPTA tetrapotassium is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA tetrapotassium shows large 19F NMR chemical shifts upon chelating divalent cations. 5,5'-Difluoro BAPTA tetrapotassium has high selectivity for Ca 2+. 5,5'-Difluoro BAPTA tetrapotassium can inhibit the growth of pollen tube .
Cat. No.: HY-W002068S
CAS No.: 1219804-63-3
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2,4-Difluorobenzoic acid-d3 is the deuterated-labeled 2,4-Difluorobenzoic acid (HY-W002068). 2,4-Difluorobenzoic acid is a difluorinated aromatic carboxylic acid. 2,4-Difluorobenzoic acid can serve as a crystalline molecular ruler for fluorine-fluorine distance measurements by 19F MAS NMR, as well as a non-radioactive passive water tracer for oilfield applications .
Cat. No.: HY-116013S1
CAS No.: 861924-55-2
Cat. No.: HY-120410
CAS No.: 1674389-55-9
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DL-4662 is a 3,4-dimethoxy derivative that can be identified using techniques such as, GC-EI-MS, LC-tandem mass spectrometry and NMR spectroscopy .
Cat. No.: HY-W209558
CAS No.: 2020-90-8
Synonyms: 2,4,5-Trimethoxyphenylacetone
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Cat. No.: HY-111333
CAS No.: 105888-54-8
Synonyms: Dioxapyrrolomycin; LL-F42248α; AL-R2081
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Cat. No.: HY-34849
CAS No.: 53531-34-3
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(R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol is utilized as a chiral shift reagent for determining enantiomeric ratios. Additionally, (R)-(-)-1-(9-Anthryl)-2,2,2-trifluoroethanol can be employed for nuclear magnetic resonance (NMR) optical purity determination .
Cat. No.: HY-119387
CAS No.: 1318025-75-0
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Cat. No.: HY-147186
CAS No.: 156027-00-8
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5,5'-Difluoro BAPTA is a difluoro-derivative of BAPTA (HY-100168). 5,5'-Difluoro BAPTA is the most widely used probe for studying cytosolic free Ca 2+ by 19F NMR. 5,5'-Difluoro BAPTA has high selectivity for Ca 2+. 5,5'-Difluoro BAPTA can inhibit the growth of pollen tube .
Cat. No.: HY-118205
CAS No.: 637772-75-9
SCH-538415 is a novel acyl carrier protein synthase inhibitor isolated from an unknown bacterial microorganism. The structural elucidation of compound 1 was completed by analyzing spectral data including UV, MS and 2D-NMR spectra. Compound 1 showed inhibitory activity in the acyl carrier protein synthase (AcpS) test with an IC50 value of 4.19 μM and exhibited antibacterial activity against Staphylococcus aureus in the agar diffusion test.
Cat. No.: HY-122038
CAS No.: 849723-20-2
NU-8165 is an inhibitor of the MDM2-p53 protein-protein interaction with anti-tumor activity. Optimization of NU-8165 was guided by MDM2 NMR titrations, which indicated key binding interaction regions. NU-8165 activated MDM2 and p21 transcription in cell-based assays and showed modest selectivity for wild-type p53 cell lines .
Cat. No.: HY-I1198
CAS No.: 2169998-23-4
Synonyms: Oxo-dapagliflozin
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Dapagliflozin keto impurity (Oxo-dapagliflozin) is an oxo metabolite and related impurity of Dapagliflozin (HY-10450). Dapagliflozin keto impurity can be characterized by 1H NMR, 13C NMR and HRMS, and can be used in studies related to Dapagliflozin impurities and metabolites .
Cat. No.: HY-165134
CAS No.: 223130-52-7
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Cat. No.: HY-L152
5,077 compounds
19F-NMR has proved to be a detection mode in fragment-based drug discovery (FBDD) for studies of protein structure and interactions. 19F shows high sensitivity for NMR detection, and the exquisite sensitivity of 19F chemical shifts and linewidths to ligand binding all make it a valuable approach in FBDD.F (Fluorine) -Fragments can be used for 19F-NMR detection after binding to target proteins, and can be used as an effective 19F-NMR tool for FBDD.
MCE designs a unique collection of 5,077 F-fragments, all of which obey a heuristic rule called the “Rule of Three (RO3)”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This F-fragments library is an important source of lead-like drugs.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
