9 Results for "

NPFF-R2

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "NPFF-R2" in MCE Product Catalog:

  • Isoforms Recommended:
Cat. No.: HY-P1248
CAS No.: 99566-27-5
Synonyms: NPFF
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain [2] .
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Cat. No.: HY-124680
CAS No.: 849459-86-5
Pureté:  99.81%
Synonyms: AC-093
Domaines de recherche:  

Inflammation/Immunology

AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research .
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Cat. No.: HY-P10380
Domaines de recherche:  

Neurological Disease Metabolic Disease

palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .
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Cat. No.: HY-P10380A
Domaines de recherche:  

Neurological Disease Metabolic Disease

palm11-PrRP31 TFA is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 TFA is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 TFA is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 TFA can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction .
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Cat. No.: HY-P10379
Domaines de recherche:  

Others Neurological Disease

palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure .
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Cat. No.: HY-RS28417
Domaines de recherche:  

Others

Npffr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cat. No.: HY-186010
CAS No.: 1958076-30-6
Domaines de recherche:  

Neurological Disease

NPFFR2 modulator-1 (compound 11) is a NPFFR2 modulator.
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Cat. No.: HY-RS09482
Domaines de recherche:  

Others

NPFFR2 Human Pre-designed siRNA Set A contains three designed siRNAs for NPFFR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS21900
Domaines de recherche:  

Others

Npffr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npffr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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