53 Results for "

Nrf2-HO-1 antioxidant pathway

" in MedChemExpress (MCE) Product Catalog:
Products (53)

53 Results for "Nrf2-HO-1 antioxidant pathway" in MCE Product Catalog:

12
Sophocarpine
Sophocarpine
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12 Publications Verification
Cat. No.: HY-N0103
CAS No.: 6483-15-4
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Plants Sophora flavescens Aiton Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK PTEN

Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
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12
Sophocarpine monohydrate
Sophocarpine monohydrate
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12 Publications Verification
Cat. No.: HY-N0103A
CAS No.: 145572-44-7
Category:  

Infection Alkaloids Piperidine Alkaloids Leguminosae Sophora japonica L. Plants Disease Research Fields Inflammation/Immunology

Target:  

Autophagy Apoptosis NF-κB PI3K Akt MEK ERK

Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine monohydrate can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine monohydrate has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .
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10
Forsythiaside A
Forsythiaside A
0 Images
10 Cited Publications
Cat. No.: HY-N0028
CAS No.: 79916-77-1
Category:  

Oleaceae Simple Phenylpropanols Phenols Polyphenols Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields Inflammation/Immunology

Target:  

Others

Forsythiaside A is an orally active phenylethanoid glycoside isolated from the dried fruits of Forsythia suspensa. Forsythiaside A is also an inhibitor of COX-2 and has anti-inflammatory, antioxidant and neuroprotective effects. Forsythiaside A prevents neuroinflammation and apoptosis caused by Aβ25-35 damage and may be used in Alzheimer's disease (AD) research. Forsythiaside A also activates the Nrf2/HO-1 signaling pathway and inhibits OVA-induced asthma in mice. Forsythiaside A inhibits the interaction between KLRB1 and CLEC2D .
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9
Danshensu
Danshensu
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9 Cited Publications
Cat. No.: HY-N1913
CAS No.: 76822-21-4
Synonyms: Dan shen suan A; Salvianic acid A
Category:  

Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .
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9
Danshensu sodium
Danshensu sodium
0 Images
9 Cited Publications
Cat. No.: HY-N1913A
CAS No.: 81075-52-7
Synonyms: Dan shen suan A sodium; Salvianic acid A sodium
Category:  

Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants

Target:  

Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .
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8
Pyridoxine
Pyridoxine
0 Images
8 Cited Publications
Cat. No.: HY-B1328
CAS No.: 65-23-6
Synonyms: Pyridoxol
Category:  

Natural Products Microorganisms Disease markers Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder

Target:  

Environmental Pollutants Endogenous Metabolite Keap1-Nrf2

Pyridoxine (Pyridoxol) is one of the components of vitamin B6. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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8
Pyridoxine hydrochloride
Pyridoxine hydrochloride
0 Images
8 Cited Publications
Cat. No.: HY-N0682
CAS No.: 58-56-0
Synonyms: Vitamin B6 hydrochloride
Category:  

Alkaloids Pyridine Alkaloids Endogenous metabolite

Target:  

Environmental Pollutants Endogenous Metabolite Keap1-Nrf2

Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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7
Loganin
Loganin
0 Images
7 Cited Publications
Cat. No.: HY-N0512
CAS No.: 18524-94-2
Synonyms: Loganoside
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Plants Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related

Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .
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3
Phosphocreatine
Phosphocreatine
0 Images
3 Cited Publications
Cat. No.: HY-D0885
CAS No.: 67-07-2
Synonyms: Creatine pHOsphate; CreatinepHOspHOric acid
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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3
Phosphocreatine disodium
Phosphocreatine disodium
0 Images
3 Cited Publications
Cat. No.: HY-D0885B
CAS No.: 922-32-7
Synonyms: Disodium creatine pHOsphate
Category:  

Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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3
Gomisin J
Gomisin J
0 Images
3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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3
Phosphocreatine disodium hydrate
Phosphocreatine disodium hydrate
0 Images
3 Cited Publications
Cat. No.: HY-D0885D
CAS No.: 19333-65-4
Category:  

Animals Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase

Phosphocreatine (disodium hydrate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine (disodium hydrate) enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine (disodium hydrate) normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine (disodium hydrate) Phosphocreatine (disodium hydrate) provides renal protection by suppressing Apoptosis and ROS (Reactive Oxygen Species) generation through ERK mediated mediated Nrf-2/HO-1 pathway. .
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2
Dihydrolipoic Acid
Dihydrolipoic Acid
0 Images
2 Cited Publications
Cat. No.: HY-116807
CAS No.: 462-20-4
Purity:  99.95%
Synonyms: DHLA
Category:  

Microorganisms Ketones, Aldehydes, Acids

Target:  

Reactive Oxygen Species (ROS)

Dihydrolipoic Acid (DHLA) is an excellent antioxidant capable of scavenging almost any oxygen-centered radical . Dihydrolipoic acid exhibits anti-inflammatory properties in various diseases. Dihydrolipoic Acid exerts a preventive effect via ERK/Nrf2/HO-1/ROS/NLRP3 pathway in LPS-induced sickness behavior rats. Dihydrolipoic Acid can be used for the reaserch of depression .
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1
Swertiamarin
Swertiamarin
0 Images
1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:  

other families Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Cancer

Target:  

MMP NF-κB JAK Keap1-Nrf2

Swertiamarin is an orally active natural product with hypoglycemic, lipid-lowering, anti-rheumatic, and antioxidant activities. Swertiamarin can regulate the levels of pro-inflammatory cytokines, MMP, and NF-κB, and promote osteoblast proliferation. Swertiamarin has antioxidant and hepatoprotective effects against carbon tetrachloride induced rat liver toxicity through the Nrf2/HO-1 pathway. Swertiamarin can attenuate inflammatory mediators by regulating JAK2/STAT3 transcription factors in adjuvant induced arthritis rats. Swertiamarin can be used in the research of diabetes and arthritis .
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1
Picein
Picein
0 Images
1 Cited Publications
Cat. No.: HY-N8698
CAS No.: 530-14-3
Category:  

Plants Nyssaceae Saccharides

Target:  

SOD Ferroptosis Keap1-Nrf2 Heme Oxygenase (HO) Glutathione Peroxidase

Picein is an antioxidant and anti-inflammatory agent. Picein can be isolated from the leaves of Picrorhiza kurroa. Picein reduces MDA levels and increases the levels of SOD, GPX and TAC. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defects by inhibiting Ferroptosis (via activation of the Nrf2/HO-1/GPX4 pathway). Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats. Picein can be used in research related to osteoporotic bone defects and Alzheimer's disease .
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1
Coniferaldehyde
Coniferaldehyde
0 Images
1 Cited Publications
Cat. No.: HY-N2535
CAS No.: 458-36-6
Synonyms: 4-Hydroxy-3-metHOxycinnamaldehyde
Category:  

other families Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Plants Disease Research Fields Inflammation/Immunology

Target:  

Keap1-Nrf2 Apoptosis

Coniferaldehyde (4-Hydroxy-3-methoxycinnamaldehyde) is an effective inducer of heme oxygenase-1 (HO-1). Coniferaldehyde inhibits LPS-induced apoptosis through the PKCα/β II/Nrf-2/HO-1 dependent pathway in RAW264.7 macrophage cells. Coniferaldehyde has antioxidant and anti-inflammatory activities .
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1
Carveol
Carveol
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1 Cited Publications
Cat. No.: HY-W017370
CAS No.: 99-48-9
Category:  

Natural Products other families Metabolic Disease Plants Endogenous metabolite Disease Research Fields

Target:  

Bcl-2 Family Caspase TNF Receptor Interleukin Related Keap1-Nrf2 Heme Oxygenase (HO) NF-κB Apoptosis α-synuclein Amylases

Carveol is an orally active monoterpenoid alcohol with neuroprotective, antioxidant, anti-inflammatory, anticonvulsant, antidiabetic, hypolipidemic and hepatoprotective activities. Carveol upregulates the expression of Bcl2, downregulates the expression of caspase-3, TNF-α, IL1β and IL6, activates the Nrf2/HO-1 antioxidant signaling pathway, inhibits the RAGE/NF-κB signaling pathway, and suppresses neuroinflammation and neuronal apoptosis. Carveol inhibits α-synuclein aggregation, improves cognitive ability, and inhibits α-amylase activity. Carveol exerts neuroprotective effects in a rat model of Parkinson's disease. Carveol exhibits antidiabetic effects in alloxan-induced diabetic rats. Carveol alleviates PTZ-induced seizures in rats. Carveol can be used in research related to Parkinson's disease, epilepsy, diabetes and ischemic stroke .
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Pyridoxine-13C4 hydrochloride
Pyridoxine-13C4 hydrochloride
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Cat. No.: HY-N0682S3
Synonyms: Pyridoxol-13C4 hydrochloride; Vitamin B6-13C4 hydrochloride
Pyridoxine- 13C4 (hydrochloride) is the 13C-labeled Pyridoxine (hydrochloride). Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
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CMIT/MIT (14.5% in water)
CMIT/MIT (14.5% in water)
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Cat. No.: HY-W017982
CAS No.: 55965-84-9
Synonyms: CMI/MI
Target:  

ERK JNK Bcl-2 Family Keap1-Nrf2 Apoptosis Interleukin Related

Research Areas:  

Inflammation/Immunology

CMIT/MIT (14.5% in water) (CMI/MI) is a mixture of CMIT and MIT, and is also a preservative and skin sensitizer. CMIT/MIT (14.5% in water) increases the levels of phosphorylated ERK1/2, p38, JNK1/2, p53, p21 and Bax, decreases the level of Bcl-2, and activates the Nrf-2/HO-1 signaling pathway. CMIT/MIT (14.5% in water) increases LDH release and lipid peroxidation levels, impairs antioxidant defense capacity, promotes pro-inflammatory cytokine release, induces apoptosis, triggers cell cycle arrest, exhibits neurotoxicity in neuroblastoma cells, and causes dysregulation of Th2/Th17 immune responses. CMIT/MIT (14.5% in water) can be used in studies related to allergy, atopic dermatitis and lung injury .
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Aloin (mixture of A&B)
Aloin (mixture of A&B)
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Cat. No.: HY-N6013
CAS No.: 8015-61-0
Category:  

Infection Liliaceae Ketones, Aldehydes, Acids Aloe vera (L.) Burm. f. Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology

Target:  

MMP Proteasome Keap1-Nrf2 TGF-beta/Smad Interleukin Related SOD Bacterial Fungal

Aloin (mixture of A&B) is an orally active anthraquinone derivative isolated from Aloe vera. Aloin (mixture of A&B) mitigates airway impairment and exerts neuroprotective, anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral and antitumor effects. Aloin (mixture of A&B) inhibits Clostridium histolyticum collagenase, granulocyte matrix metalloproteinases and human 20S proteasome. Aloin (mixture of A&B) upregulates the Nrf2/HO-1 pathway, suppresses the TGF-β/Smad2/3 pathway. Aloin (mixture of A&B) reduces IL-4/IL-5/IL-13 levels, and reverses oxidative stress markers (MDA, SOD, GSH). Aloin (mixture of A&B) can be used for research on chronic ulcers, burns, wounds, inflammatory and degenerative disorders, asthma and neuroblastoma .
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