22 Results for "

OSBP

" in MedChemExpress (MCE) Product Catalog:
Products (22)

22 Results for "OSBP" in MCE Product Catalog:

24
24 Publications Verification
Cat. No.: HY-17514
CAS No.: 84625-61-6
Synonyms: R51211
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
loading...
    loading...
5
5 Cited Publications
Cat. No.: HY-101213
CAS No.: 145075-81-6
Purity:  98.84%
OSW-1, isolated from Ornithogalum caudatum, is a specific antagonist of ooxysterol binding protein (OSBP) and OSBP-related protein 4 (ORP4) with GI50s in the nanomolar range in human cancer lines.
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-124806
CAS No.: 950225-08-8
Purity:  99.90%
Research Areas:  

Infection

TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP) .
loading...
    loading...
Cat. No.: HY-148391
CAS No.: 790224-37-2
Synonyms: SBF-1
Target:  

DNA/RNA Synthesis

Research Areas:  

Cancer

23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity .
loading...
    loading...
Cat. No.: HY-17514S1
CAS No.: 1217512-35-0
Synonyms: R51211-d3
Itraconazole-d3 (R51211-d3) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
loading...
    loading...
Cat. No.: HY-17514R
CAS No.: 84625-61-6
Synonyms: R51211 (Standard)
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
loading...
    loading...
Cat. No.: HY-178035
CAS No.: 2890760-73-1
OSBP ligand-1 (Compound 2) is an Oxysterol-binding protein (OSBP) inhibitor. OSBP ligand-1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .
loading...
    loading...
Cat. No.: HY-178046
OSBP ligand-Linker Conjugate 1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for OSBP (HY-178035) and a PROTAC linker, which recruits E3 ligases. OSBP ligand-Linker Conjugate 1 can be used for synthesis of PROTAC OSBP Degrader-1 (HY-178034) .
loading...
    loading...
Cat. No.: HY-156275
CAS No.: 2890760-43-5
Target:  

Others

Research Areas:  

Cancer

OSBP-IN-1(compound 12) is a Schweinfurthins analogues targeted of oxysterol-binding protein (OSBP). OSBP-IN-1 has antitumor activity .
loading...
    loading...
Cat. No.: HY-17514S2
CAS No.: 1309272-50-1
Synonyms: R51211-d9
Itraconazole-d9 is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .
loading...
    loading...
Cat. No.: HY-178034
PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC50 of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells . Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker
loading...
    loading...
Cat. No.: HY-RS09835
Research Areas:  

Others

OSBP Human Pre-designed siRNA Set A contains three designed siRNAs for OSBP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS26430
Research Areas:  

Others

Osbp Rat Pre-designed siRNA Set A contains three designed siRNAs for Osbp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS09836
Research Areas:  

Others

OSBP2 Human Pre-designed siRNA Set A contains three designed siRNAs for OSBP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-163891
CAS No.: 2684411-12-7
Target:  

Fungal

Research Areas:  

Infection

Antifungal agent 107 (compound b24) is an OSBP inhibitor with antifungal activity. Antifungal agent 107 can be used to control cucumber downy mildew and potato late blight in greenhouse .
loading...
    loading...
Cat. No.: HY-RS19928
Research Areas:  

Others

Osbp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Osbp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-P88527
Synonyms: OSBP1

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P88527A
Synonyms: OSBP1

Host:  

Mouse

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P88549
Synonyms: ORP-11; ORP11; OSBP12; TCCCIA00292

Host:  

Mouse

Application:  

ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

loading...
    loading...
Cat. No.: HY-P81732
Synonyms: ORP1; OSBP8; OSBPL1; OSBPL1B

Host:  

Rabbit

Application:  

WB, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

loading...
    loading...