Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
42 Results for "
PCNA
" in MedChemExpress (MCE) Product Catalog:
Products (42)
42 Results for "PCNA" in MCE Product Catalog:
2
2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
2
2 Cited Publications
Target:
Research Areas:
T2AA is a monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibitor that prevents DNA repair, increases double-strand break (DSB) formation and promotes necroptosis and cell cycle arrest in G1 phase .
2
2 Cited Publications
Cat. No.: HY-N0095
CAS No.: 19685-09-7
Synonyms: 10-HCPT; 10-Hydroxycamptothecin
Category:
Pyrrole Alkaloids Quinoline Alkaloids Camptotheca acuminata Decne. Plants Nyssaceae Alkaloids Monophenols Phenols Disease Research Fields Cancer
Target:
1
1 Cited Publications
Target:
Research Areas:
AOH1160 is a potent oral small molecule proliferating cell nuclear antigen (PCNA) inhibitor that interferes with DNA replication, blocks homologous recombination-mediated DNA repair, leads to cell cycle arrest and induces apoptosis .
1
1 Cited Publications
Cat. No.: HY-P4322
CAS No.: 131167-89-0
Research Areas:
1
Research Areas:
Linuron is a phenylurea herbicide widely used to control the growth of grasses and weeds in various crops and orchards. Linuron acts as a photosystem II inhibitor. It also functions as a competitive androgen receptor (AR) antagonist, with an EC50 of 200 μM and a Ki of 100 μM against rat AR, and an EC50 of 20 μM against human AR. Linuron exhibits reproductive toxicity in animals and acts as an endocrine disruptor .\n
1
1 Cited Publications
Cat. No.: HY-NP199
1
1 Cited Publications
Cat. No.: HY-P73729
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Proliferating cell nuclear antigen; PCNA; Cyclin
Species:
Source:
Target:
Research Areas:
PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen (PCNA) with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure (Kd=0.14-0.41μM), reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors .
Cat. No.: HY-160700
CAS No.: 2839740-79-1
Target:
Research Areas:
TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) .
Cat. No.: HY-125576
CAS No.: 26034-16-2
Target:
Research Areas:
I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells .
Research Areas:
Meptyldinocap (2,4-DNOPC) is a fungicide and cytotoxic agent that acts against powdery mildew. Meptyldinocap upregulates the phosphorylation levels of ERK1/2, JNK and p38. Meptyldinocap induces apoptosis and endoplasmic reticulum stress, disrupts calcium homeostasis, inhibits cell proliferation and migration, downregulates the expression of proliferation- and pregnancy-related genes, and triggers mitochondrial dysfunction. Meptyldinocap can be used in studies related to powdery mildew and implantation failure .
Target:
Research Areas:
Mabuterol is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .
Cat. No.: HY-200129
CAS No.: 1417653-45-2
Target:
Research Areas:
PCNA-IN-1 (Compound 11) is a PCNA/PIP-box interaction inhibitor, with IC50 of >50 μM. PCNA-IN-1 can be used in research of cancer .
Cat. No.: HY-RS10159
Target:
Research Areas:
PCNA Human Pre-designed siRNA Set A contains three designed siRNAs for PCNA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23107
Target:
Research Areas:
Pcna Rat Pre-designed siRNA Set A contains three designed siRNAs for Pcna gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10825
Target:
Research Areas:
Cat. No.: HY-W755295
CAS No.: 54240-36-7
Target:
Research Areas:
Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
