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Results for "

PTPs

" in MedChemExpress (MCE) Product Catalog:

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By Research Areas:	Cancer (71) Cardiovascular Disease (9) Endocrinology (6) Infection (13) Inflammation/Immunology (35) Metabolic Disease (91) Neurological Disease (14)
Oligonucleotides:	Pegylated Lipids (4) Rat Pre-designed siRNA Sets (3) Phospholipids (1) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) Antisense Oligonucleotides (5) siRNAs (11)

211

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
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Recombinant Proteins

Antibodies

Oligonucleotides

Razuprotafib 4 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of *VE-PTP* (vascular endothelial protein tyrosine phosphatase) with an IC₅₀*of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP* versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

NSC-87877 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Others
NSC-87877 is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

PTP inhibitor 1	Phosphatase	Cancer
PTP inhibitor 1 is a *protein tyrosine phosphatase (PTP)* inhibitor, with anti-angiogenic effect .

Bis(maltolato)oxovanadium(IV) BMOV	SHP2 Phosphatase	Metabolic Disease
Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases) inhibitor. Bis(maltolato)oxovanadium(IV) inhibits HCPTPA, *PTP1B, HPTPβ* and SHP2 with IC₅₀s of 126 nM, 109 nM, 26 nM and 201 nM, respectively. Bis(maltolato)oxovanadium(IV) is a potent insulin sensitizer .

PHPS1 5 Publications Verification	SHP2 SHP1 Phosphatase	Cardiovascular Disease Cancer
PHPS1 is a potent and selective Shp2 inhibitor with K_is of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively .

DPM-1001	Phosphatase	Metabolic Disease
DPM-1001 is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 has anti-diabetic property .

SPI-112 1 Publications Verification	SHP2 Phosphatase	Cancer
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC₅₀s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively .

bpV(phen) 3 Publications Verification	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, *PTP-β* and *PTP-1B, respectively. bpV(phen) inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

PTP1B-IN-2 4 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC₅₀ of 50 nM.

PTP1B-IN-1 5 Publications Verification PTP1B inhibitor	Phosphatase NF-κB	Neurological Disease Inflammation/Immunology
PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of *PTP1B* with an IC₅₀ value of 1.6 mM. It is often used as the mother core for derivatives of analogues .

JMS-053 3 Publications Verification	Phosphatase STAT Ras	Cancer
JMS-053 is an efficient and reversible *PTP4A3* inhibitor, with an IC₅₀ value of 18 nM. JMS-053 demonstrates broad *PTP4A* inhibitory activity with IC₅₀s of 50 nM and 53 nM for *PTP4A1* and *PTP4A2, respectively. JMS-053 exhibits IC₅₀* values of 92.6 nM and 207.6 nM for CDC25B and DUSP3, respectively. JMS-053 can effectively inhibit the activity of PTP4A3, inhibit tumor cell proliferation and migration through multiple mechanisms such as interfering with RhoA and STAT3/p38 signaling pathway. JMS-053 can be used for the study of cancers such as ovarian cancer, breast cancer and colon cancer .

PTP1B-IN-4 1 Publications Verification	Phosphatase	Metabolic Disease
PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase *PTP1B, with an IC₅₀* of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes .

TCS 401 2 Publications Verification	Phosphatase	Metabolic Disease
TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

NSC-87877 disodium 3 Publications Verification	SHP2 SHP1 Phosphatase Apoptosis	Cancer
NSC-87877 disodium is a potent inhibitor of Shp2 and Shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1), with IC₅₀ values of 0.318 μM, 0.355 μM shp2 and shp1, respectively . NSC-87877 also inhibits dual-specificity phosphatase 26 (DUSP26) .

MLS-0437605 1 Publications Verification	Phosphatase	Cardiovascular Disease
MLS-0437605 is a selective dual-specificity phosphatase 3 (DUSP3) inhibitor with an IC₅₀ of 3.7 μM. MLS-0437605 is more selective for DUSP3 than DUSP22 and other protein tyrosine phosphatases (PTPs) .

*DU-14 (PTP1B/TC-PTP* PROTAC)**	PROTACs STAT	Cancer
DU-14 (PTP1B/TC-PTP PROTAC) is a potent and selective *PTP1B* and *TC-PTP* dual PROTAC degrader. DU-14 (PTP1B/TC-PTP PROTAC) has the IC₅₀ for *PTP1B* and *TC-PTP* phosphatase activity of 24.2 nM and 30.1 nM, respectively. DU-14 (PTP1B/TC-PTP PROTAC) enhances IFN-γ signaling, promotes T cell activation, and has anti-tumor activity. (Pink: PTP1B/TC-PTP inhibitor (HY-171027); Black: Linker (HY-W340290); Blue: E3 ligand (HY-112078)) .

PTP1B-IN-3	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 has antidiabetic and anticancer effects .

BpV(phen) trihydrate 3 Publications Verification Bisperoxovanadium(phen) trihydrate	PTEN Phosphatase Parasite Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
BpV(phen) trihydrate, a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC₅₀s of 38 nM, 343 nM and 920 nM for PTEN, *PTP-β* and *PTP-1B, respectively. BpV(phen) trihydrate inhibits proliferation of the protozoan parasite Leishmania* in vitro. bpV(phen) trihydrate strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ). BpV(phen) trihydrate can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity .

PTPσ Inhibitor, ISP	Phosphatase	Neurological Disease
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .

Uralenol	Phosphatase	Metabolic Disease
Uralenol is a natural *PTP1B* inhibitor (IC₅₀=21. 5 μM) from Broussonetia papyrifera. PTP1B have been shown to play a major role in the dephosphorylation of the insulin receptor in many cellular and biochemical studies .

Ertiprotafib 2 Publications Verification PTP 112	Phosphatase IKK PPAR	Metabolic Disease
Ertiprotafib is an inhibitor of PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist, with an IC₅₀ of 1.6 μM for PTP1B, 400 nM for IKK-β, an EC₅₀ of ~1 μM for PPARα/PPARβ.

PTP Inhibitor IV	Phosphatase SHP2	Cancer
PTP Inhibitor IV is a protein tyrosine phosphatase (PTP) inhibitor that competitively inhibits DUSP14 phosphatase activity with an ₅₀ of 5.21 μM . PTP Inhibitor IV inhibits SHP-2, PTP1B, PTP-ε, PTP Meg-2, PTP-σ, PTP-β, and PTP-μ with ₅₀s of 1.8 μM, 2.5 μM, 8.4 μM, 13 μM, 20 μM, 6.4 μM, and 6.7 μM, respectively .

PTP1B-IN-24	Phosphatase Insulin Receptor Akt	Metabolic Disease
PTP1B-IN-24 (Compound 9) is a reversible *PTP1B* inhibitor with an IC₅₀ value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of *PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1* and AKT .

DPM-1001 trihydrochloride	Phosphatase	Metabolic Disease
DPM-1001 trihydrochloride is a potent, specific, orally active and non-competitive inhibitor of protein-tyrosine phosphatase (PTP1B) with an IC₅₀ of 100 nM. DPM-1001 trihydrochloride is an analog of the specific PTP1B inhibitor MSI-1436. DPM-1001 trihydrochloride has anti-diabetic property .

CN009543V	EGFR p38 MAPK ERK Phosphatase	Cancer
CN009543V is an epidermal growth factor receptor (EGFR) agonist. CN009543V enhances tyrosine phosphorylation of EGFR at Tyr1068 and Tyr1173, thereby activating the MAPK/ERK cascade. CN009543V inhibits the activity of *PTP-1B* in MDA MB468 cells. CN009543V can be used in cancer research .

3,5-Difluoro-L-tyrosine	Phosphatase	Others
3,5-Difluoro-L-tyrosine is a functional, tyrosinase-resistant mimetic of tyrosine. 3,5-Difluoro-L-tyrosine can be used to analyze the substrate specificity of protein tyrosine phosphatases (PTPs) .

*PROTAC PTP1B degrader 1*	PROTACs Phosphatase	Metabolic Disease
PROTAC PTP1B degrader 1 (compound 75) is a CRBN-based *PTP1B* PROTAC degrader, with DC₅₀ values of 0.2 μM (48 h) and 0.05 μM (72 h) (Red: PTP1B ligand Oleanolic acid (HY-N0156); Black: linker; Blue: CRBN ligand) .

JTT 551	Phosphatase	Metabolic Disease
JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with K_is of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus.

S-15176	Mitochondrial Metabolism	Cardiovascular Disease
S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP). S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC₅₀ value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD(P)H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury .

PTP1B-IN-22	Phosphatase	Metabolic Disease
PTP1B-IN-22, a ZINC02765569 derivative, is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor. PTP1B-IN-22 has PTP1B inhibition and glucose uptake in skeletal muscle L6 myotubes .

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

PTP1B-IN-25	Phosphatase Fungal HIV Bacterial	Infection Metabolic Disease
PTP1B-IN-25 (Compound 19) is a *PTP1B* inhibitor with remarkable antiviral, antibacterial, and antidiabetic activities. PTP1B-IN-25 has IC₅₀ values of 0.37 μM, 8.6 μM, 3.7 μM, and 29 μM against *PTP1B, HIV, α-Glucosidase, and methicillin-resistant Staphylococcus aureus* (MRSA) respectively .

*IONIS PTP1BRx* ISIS 404173	Phosphatase	Metabolic Disease
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

DPM-1003	Phosphatase	Inflammation/Immunology
DPM-1003 is a *PTP1B* conformational inhibitor that targets the non-catalytic, disordered segment at the C-terminus of the *PTP1B* protein, showing improvement in lung inflammation in mice .

Anticancer agent 144	Phosphatase	Cancer
Anticancer agent 144 (compound 444) is a dual *PTPN2/PTP1B* inhibitor with IC₅₀ values <2.5 nM. Anticancer agent 144 can be used in cancer research .

PTS Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTS Human Pre-designed siRNA Set A contains three designed siRNAs for PTS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTP1B/TC-PTP IN-1	Ligands for Target Protein for PROTAC	Cancer
PTP1B/TC-PTP IN-1 is a *PTP1B* and *TC-PTP* dual inhibitor. PTP1B/TC-PTP IN-1 can be used as a target protein ligand for the synthesis of DU-14 (PTP1B/TC-PTP PROTAC) (HY-164864) .

PTP1B-IN-26	Phosphatase Amyloid-β	Metabolic Disease
PTP1B-IN-26 (Compound 7a) is a derivative of phenylthiosemicarbazide‐phenoxy‐1,2,3‐triazole‐N‐phenylacetamide. PTP1B-IN-26 is an inhibitor of protein tyrosine phosphatase 1B (PTP-1B). PTP1B-IN-26 is a competitive inhibitor. PTP1B-IN-26 can be used to research in type 2 diabetes .

PTP1B-IN-32	Phosphatase	Metabolic Disease
PTP1B-IN-32 (Compound 5G) is an uncompetitive *PTP1B* inhibitor, with a K_i value of 0.72 μM. PTP1B-IN-32 enhances insulin sensitivity. PTP1B-IN-32 can be used in the research of diabetes .

PTP1B-IN-3 diammonium	Phosphatase	Metabolic Disease Cancer
PTP1B-IN-3 diammonium is a potent and orally active *PTP1B* inhibitor with IC₅₀s of 120 nM for both *PTP1B* and TCPTP. PTP1B-IN-3 diammonium has antidiabetic and anticancer effects .

*TC-PTP-IN-1*	Phosphatase	Cancer
TC-PTP-IN-1 (compound 8) is a potent *TC-PTP* inhibitor with an IC₅₀ value of 9.2 nM, K_i values of 4.3, 34 nM for TC-PTP, PTP1B, respectively. TC-PTP-IN-1 increases the protein expression of pSre416 . TC-PTP-IN-1 (compound 3) is the TC-PTP Ligand of TP1L (HY-160151) .

PTP1B-IN-31	Phosphatase	Inflammation/Immunology Cancer
PTP1B-IN-31 (Compound (S,S)-3ak) is a *PTP1B* inhibitor with an IC₅₀ of 0.81 μM. PTP1B-IN-31 can inhibit the growth of tumor cells in synergy with the cytokine IFNγ. PTP1B-IN-31 can be used in cancer research .

DSPE-PEG5000-Mal-Cys-KTLLPTP	Liposome	Cancer
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

DSPE-PEG1000-Mal-Cys-KTLLPTP	Liposome	Cancer
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

DSPE-PEG2000-Mal-Cys-KTLLPTP	Liposome	Cancer
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

PTP1B-IN-18	Phosphatase	Metabolic Disease
PTP1B-IN-18 is an orally active complete mixed type protein tyrosine phosphatase 1B (PTP1B) inhibitor with a K_i of 35.2 μM. PTP1B-IN-18 can be used for type 2 diabetes research .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library

174 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 174 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Type

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE	Biochemical Assay Reagents
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and *PTP1B* activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

HY-172270D

DSPE-PEG5000-Mal-Cys-KTLLPTP	Biochemical Assay Reagents
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-172270

DSPE-PEG1000-Mal-Cys-KTLLPTP	Biochemical Assay Reagents
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-172270A

DSPE-PEG2000-Mal-Cys-KTLLPTP	Biochemical Assay Reagents
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-172270C

DSPE-PEG3400-Mal-Cys-KTLLPTP	Biochemical Assay Reagents
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

Cat. No.	Product Name	Target	Research Area

HY-P5247

Palmitoyl tetrapeptide-20 PTP20	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce H₂O₂ accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying .

HY-P5982

PTPσ Inhibitor, ISP	Phosphatase	Neurological Disease
PTPσ Inhibitor, ISP can bind to recombinant human PTPs and inhibits PTPσ signaling. PTPσ Inhibitor, ISP can penetrate the membrane and relieves the chondroitin sulfate proteoglycan (CSPG)-mediated axonal sprouting inhibition in spinal cord injury model. PTPσ Inhibitor, ISP enhances remyelination in LPC-induced demyelinated spinal cord. PTPσ Inhibitor, ISP also promotes oligodendrocyte progenitor cells (OPCs) migration, maturation, remyelination, and functional recovery in animal models of Multiple Sclerosis (MS) .

HY-P5247A

Palmitoyl tetrapeptide-20 TFA PTP20 TFA	Melanocortin Receptor Sirtuin	Metabolic Disease Inflammation/Immunology
Palmitoyl tetrapeptide-20 (PTP20) TFA is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 TFA promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC₅₀: 0.16 nM), enhancing catalase activity to reduce H₂O₂ accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 TFA can be used in research on preventing hair loss and improving hair graying .

HY-P3599

P-T-P-S-NH2	Peptides	Others
P-T-P-S-NH2 is a short-chain peptide with an N-terminal proline .

HY-P0320B

EGF Receptor Substrate 2 (Phospho-Tyr5) acetate	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P0320A

EGF Receptor Substrate 2 (Phospho-Tyr5) TFA	Phosphatase Biochemical Assay Reagents	Others
EGF Receptor Substrate 2 (Phospho-Tyr5) acetate, a biologically active peptide, is a tyrosine phosphate substrate. EGF Receptor Substrate 2 (Phospho-Tyr5) acetate can be used to detect protein tyrosine phosphatases activity .

HY-P1799

[pTyr5] EGFR (988-993)	Phosphatase	Others
[pTyr5] EGFR (988-993) is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P1799A

[pTyr5] EGFR (988-993) TFA	Phosphatase	Others
[pTyr5] EGFR (988-993) TFA is derived from the autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR 988-993). [pTyr5] EGFR (988-993) TFA is often complexed with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B) .

HY-P4528

Ala-Phe-Pro-βNA	Ser/Thr Protease	Others
Ala-Phe-Pro-βNA is the subsrate of prolyl tripeptidyl aminopeptidase, which is from Porphyromonas gingivalis. Ala-Phe-Pro-βNA binds to H-Ala-Ile-pyrrolidin-2-yl boronic acid for PTP39 and the E636A mutant with K_i values of 88.1 nM and 48.8 nM, respectivley .

Cat. No.	Product Name

HY-K0022

Phosphatase Inhibitor Cocktail Ⅱ (100× in ddH₂O) 455+ Cited Publications
Phosphatase Inhibitor Cocktail Ⅱ (100× in ddH₂O) is a blend of 5 phosphatase inhibitors that can broadly inhibit acid phosphatases, alkaline phosphatases, and protein tyrosine phosphatases (PTPs).The 1 mL volume is defined as the base specification. All larger sizes correspond to incremental volumes of this base.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991852

Anti-CD45RO Antibody (UCHL-1)	Phosphatase	Cancer
Anti-CD45RO Antibody (UCHL-1) reacts with the human CD45RO. CD45 is a glycoprotein member of the protein tyrosine phosphatase (PTP) family known for its involvement in regulating a variety of cellular processes. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73684

	PTS Protein, Human (His) 6-pyruvoyl tetrahydrobiopterin synthase; PTP synthase; PTPs; PTS	Human	E. coli
	PTS proteins are critical in the biosynthesis of tetrahydrobiopterin, an important cofactor for aromatic amino acid hydroxylase. It catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin, a key step in the biosynthetic pathway. PTS Protein, Human (His) is the recombinant human-derived PTS protein, expressed by E. coli , with N-His labeled tag.

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Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2) IP (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Phosphorylated (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82891

	Phospho-PTS (Ser19) Antibody (YA2636) PTPs	WB, IHC-P, IP	Human
	Phospho-PTS (Ser19) Antibody (YA2636) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTS (Ser19).

HY-P82891A

	Phospho-PTS (Ser19) Antibody (YA2636)(PBS only) PTPs	WB, IHC-P, IP	Human
	Phospho-PTS (Ser19) Antibody (YA2636) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-PTS (Ser19).

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Cat. No.	Product Name		Classification

HY-157673

1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 16:1 PE		Phospholipids
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance PP2A and *PTP1B* activities in malignant pleural mesothelioma cells. 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis of NCI-H28 malignant pleural mesothelioma cells .

HY-159694

*IONIS PTP1BRx* ISIS 404173		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-RS11455

PTS Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTS Human Pre-designed siRNA Set A contains three designed siRNAs for PTS gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172270D

DSPE-PEG5000-Mal-Cys-KTLLPTP		Pegylated Lipids
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-172270

DSPE-PEG1000-Mal-Cys-KTLLPTP		Pegylated Lipids
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-172270A

DSPE-PEG2000-Mal-Cys-KTLLPTP		Pegylated Lipids
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-159694A

*IONIS PTP1BRx sodium* ISIS 404173 sodium		Antisense Oligonucleotides
IONIS PTP1BRx (ISIS 404173) sodium is an antisense inhibitor of protein tyrosine phosphatase 1B (PTP-1B). IONIS PTP1BRx sodium shows antidiabetic activity, and can be used for the study of insulin resistance and type 2 diabetes mellitus associated with obesity .

HY-RS26696

Ptp4a2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ptp4a2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11409

PTP4A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTP4A1 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11410

PTP4A2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTP4A2 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26303

Ptp4a3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ptp4a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11411

PTP4A3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTP4A3 Human Pre-designed siRNA Set A contains three designed siRNAs for PTP4A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20244

Pts Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Pts Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pts gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-172270C

DSPE-PEG3400-Mal-Cys-KTLLPTP		Pegylated Lipids
DSPE-PEG1000-PTP is synthesised by conjugating the amino group of plectin-1 peptide (PTP) with DSPE-PEG-NHS ester via amide bonds. DSPE-PEG1000-PTP can be used to construct drug delivery vectors .

HY-159694C

*FAM labled IONIS PTP1BRx sodium*		Antisense Oligonucleotides
FAM labled IONIS PTP1BRx sodiumis a FAM labled IONIS PTP1BRx sodium.

HY-159694D

*Cy3 labled IONIS PTP1BRx sodium*		Antisense Oligonucleotides
Cy3 labled IONIS PTP1BRx sodium is a Cy3 labled IONIS PTP1BRx sodium.

HY-159694B

*IONIS PTP1BRx sodium scrambled negative control*		Antisense Oligonucleotides
IONIS PTP1BRx sodium scrambled negative control is the sequence scrambled negative control of IONIS PTP1BRx sodium.

HY-RS19807

Ptp4a3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptp4a3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS26302

Ptp4a1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ptp4a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20192

Ptp4a2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptp4a2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19806

Ptp4a1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptp4a1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptp4a1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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