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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
Phase-2
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "Phase-2" in MCE Product Catalog:
Cat. No.: HY-P991127
CAS No.: 2922766-89-8
Synonyms: DNTH103
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Cat. No.: HY-N7335
CAS No.: 199331-35-6
Category:
Neurological Disease Leguminosae Extract Plants Flavonoids Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Isoflavones
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Cat. No.: HY-B0615AS
CAS No.: 2300178-76-9
Synonyms: EN 313-d8; Ethmozin-d8; Moracizine-d8
Cat. No.: HY-W975966
CAS No.: 14085-33-7
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CPDT is an orally active and highly potent inducer of phase 2 enzymes and an activator of Nrf2. The activities of key phase 2 enzymes, including glutathione S-transferase, NAD(P)H:quinone:oxidoreductase 1 and glutamate cysteine synthetase, and levels of glutathione were elevated by CPDT in rat bladder in vivo and in cultured bladder cells in vitro [1][2].
Cat. No.: HY-15882
CAS No.: 1200127-66-7
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GNE-783 is a selective CHK1 inhibitor that enhances the activity of gemcitabine. GNE-783 improves the efficacy of anti-metabolite DNA damage drugs by inactivating S-phase and G2-phase cell cycle checkpoints following DNA damage. GNE-783 selectively enhances the chemical synergy of certain drugs in different tumor types, for example, enhancing the activity of temozolomide only in melanoma cell lines .
Cat. No.: HY-B0615A
CAS No.: 29560-58-5
Synonyms: EN 313; Ethmozin; Moracizine
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Moricizine Hydrochloride (EN 313) is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .
Cat. No.: HY-117688
CAS No.: 1620054-84-3
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WJ35435 is a dual-targeted anticancer hybrid that induces anti-HDAC (in particular HDAC1 and HDAC6) and anti-topoisomerase I activities that causes DNA damage associated with a low DNA repair capability and induces cell cycle arrest at G1- and G2-phase to apoptosis. WJ35435 induces histone H3 acetylation and phosphorylation, α-tubulin acetylation and γ-H2AX formation to achieve anti-HDAC effect. WJ35435 is promising for research of cancer .
Cat. No.: HY-187506
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ZSL-M028 is an orally active and selective Polo-like kinase 4 (PLK4) inhibitor with an IC50 value of 1.1 nM. ZSL-M028 exhibits anti-tumor activity against TRIM37-amplified neuroblastoma, downregulates SAS6, upregulates FBXW5, induces G2-phase cell cycle arrest and apoptosis, activates the p53 signaling pathway, and inhibits tumor cell colony formation and migration. ZSL-M028 shows significant tumor growth inhibitory activity in the IMR-32 neuroblastoma xenograft model. ZSL-M028 can be used in neuroblastoma-related research .
Cat. No.: HY-177543
CAS No.: 65490-84-8
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5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione is a Phase 2 enzyme inducer. 5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione induces the activity of NAD (P) H:quinone oxidoreductase (QR; NQO1) in hepatoma cells. 5-(4-Methoxyphenol)-4-methyl-3H-1,2-dithiole-3-thione enhances growth hormone production in plasmid-transfected hepatoma cells .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
