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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
Pyrin
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "Pyrin" in MCE Product Catalog:
13
13 Publications Verification
Cat. No.: HY-P80246
Synonyms: C1orf7, CIAS1, NALP3, PYPAF1, NLRP3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, Cold-induced autoinflammatory syndrome 1 protein, CryoPyrin, Pyrin-containing APAF1-like protein 1, CLR1.1
6
1
1 Cited Publications
Cat. No.: HY-P71598
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NLRP3; AII; Prev. CIAS1; Cold-Induced Autoinflammatory Syndrome 1 Protein; Prev. C1orf7; Pyrin-Containing APAF1-Like Protein 1; Prev. DFNA34; Deafness, Autosomal Dominant 34; CLR1.1; Caterpiller Protein 1.1; PYPAF1; NACHT Domain-, Leucine-Rich Repeat-, An
Species:
Mouse
Source:
E. coli
1
1 Cited Publications
Cat. No.: HY-P790108
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NLRP3; AII; Prev. CIAS1; Cold-Induced Autoinflammatory Syndrome 1 Protein; Prev. C1orf7; Pyrin-Containing APAF1-Like Protein 1; Prev. DFNA34; Deafness, Autosomal Dominant 34; CLR1.1; Caterpiller Protein 1.1; PYPAF1; NACHT Domain-, Leucine-Rich Repeat-, An
Species:
Human
Source:
E. coli
Target:
Research Areas:
BAA473 is a bile acid analog and is a potent activator of the pyrin inflammasome that induces the secretion of interleukin 18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial cells .
Target:
Research Areas:
Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
NLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and numerous other autoinflammatory diseases .
Cat. No.: HY-161727
CAS No.: 2728291-29-8
Target:
Research Areas:
P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis .
Cat. No.: HY-157555
CAS No.: 2198483-40-6
Target:
Research Areas:
NLRP3-IN-29(Compound 5M) is an inhibitor of NLR family pyrin domain containing 3 (NLRP3). NLRP3-IN-29 has the potential for blood-brain barrier permeability and inflammation inhibition both in vivo and in vitro. NLRP3-IN-29 can be used for research on Alzheimer's disease .
Cat. No.: HY-113224R
CAS No.: 313-04-2
Cat. No.: HY-RS27287
Target:
Research Areas:
Mefv Rat Pre-designed siRNA Set A contains three designed siRNAs for Mefv gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS20773
Target:
Research Areas:
Mefv Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mefv gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701994
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PYHIN1; Interferon-Inducible Protein X; Pyrin And HIN Domain Family Member 1; MGC23885; IFIX; Pyrin And HIN Domain Family, Member 1; Pyrin And HIN Domain-Containing Protein 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P701995
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PYHIN1; Interferon-Inducible Protein X; Pyrin And HIN Domain Family Member 1; MGC23885; IFIX; Pyrin And HIN Domain Family, Member 1; Pyrin And HIN Domain-Containing Protein 1
Species:
Human
Source:
E. coli
Cat. No.: HY-P703389
Synonyms: NLRP4; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 4; Prev. NALP4; NACHT, LRR And PYD Domains-Containing Protein 4; PYPAF4; Pyrin-Containing APAF1-Like Protein 4; PAN2; Pyrin And NACHT-Containing Protein 2; R
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703410
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NLRP9; Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 9; Prev. NALP9; NACHT, Leucine Rich Repeat And PYD Containing 9; PAN12; NACHT, LRR And PYD Domains-Containing Protein 9; NOD6; Pyrin And NACHT-Containing Pro
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703337
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: NLRP2; Pyrin Domain And NACHT Domain-Containing Protein 1; Prev. NALP2; NACHT, LRR And PYD Domains-Containing Protein 2; PYPAF2; Pyrin-Containing APAF1-Like Protein 2; NBS1; Nucleotide-Binding Site Protein 1; PAN1; FLJ20510; CLR19.9; OZEMA18; Nucleotide-B
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P703399
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: NLRP7; NACHT, Leucine Rich Repeat And PYD Containing 7; Prev. NALP7; NACHT, LRR And PYD Containing Protein 7; PYPAF3; Pyrin-Containing Apaf1-Like Protein 3; NOD12; Pyrin-Containing APAF1-Like Protein 3; CLR19.4; NLRP7 Protein; PAN7; OZEMA25; Nucleotide-Bi
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-L175
178 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.
MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
