16 Results for "

RFamide

" in MedChemExpress (MCE) Product Catalog:
Products (16)

16 Results for "RFamide" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P1103
CAS No.: 1030384-98-5
Target:  

CXCR

Research Areas:  

Cancer

CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .
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Cat. No.: HY-P4070
CAS No.: 1188379-43-2
Target:  

Insulin Receptor

Research Areas:  

Metabolic Disease

Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .
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Cat. No.: HY-P1248
CAS No.: 99566-27-5
Synonyms: NPFF
Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, is a NPFF1 and NPFF2 receptors agonist with Ki values of 2.82 nM and 0.21 nM, respectively. Neuropeptide FF induces abstinence syndrome, exerts antiopioid and analgesic effects, releases via calcium-dependent mechanisms from rat spinal cord, regulates memory, autonomic function, and neuroendocrine function, modulates pain and opioid antinociception, reduces food intake, stimulates water intake, alters cardiovascular parameters, and shows differential activity in hypothalamic paraventricular nucleus neurons. Neuropeptide FF is present in mammalian central nervous system and periphery, with NPFF-immunoreactivity increases in rat cerebrospinal fluid during opiate tolerance, and its NPFF gene and NPFF-R2 gene are up-regulated in rat spinal cord and dorsal root ganglia during peripheral inflammation. Neuropeptide FF can be used for the research of opioid tolerance, morphine-induced analgesia, abstinence syndrome, pain, hypertension, nociception, inflammatory pain, and neuropathic pain .
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Cat. No.: HY-P3843
CAS No.: 99588-52-0
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC50 of ~60 nM) and MrgprC11 (EC50 of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC50 of ~25-325 nM) and NPFF2 (EC50 of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .
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Cat. No.: HY-P2655
CAS No.: 107535-01-3
Target:  

Peptides

Research Areas:  

Others

Antho-RFamide is a neuropeptide isolated from the sea anemone (Anthopleura elegantissima). Antho-RFamide contains a specific carboxyl-terminal sequence, Arg-Phe-NH2, that plays an important role in neural signaling. Antho-RFamide can be used to study the function of neuropeptides in the nervous system of the simplest animals .
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Cat. No.: HY-P1103A
Target:  

CXCR

Research Areas:  

Cancer

CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .
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Cat. No.: HY-P11293
CAS No.: 1309855-53-5
Target:  

Melanocortin Receptor

Research Areas:  

Cancer

DOTA-GGNle-CycMSHhex is a melanocortin-1 receptor (MC1R)-targeting peptide that can be radionuclide-labeled for melanoma imaging .
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Cat. No.: HY-P4757
CAS No.: 108081-77-2
Target:  

Parasite

Research Areas:  

Others

N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .
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Cat. No.: HY-123028
CAS No.: 34388-59-5
Synonyms: Arginylphenylalaninamide
Target:  

Others

Research Areas:  

Others

RFamide (Arginylphenylalaninamide) is a neuropeptide that has contraction-inducing activity in gastropod muscles. Its contractile effect is additive with acetylcholine and is regulated by 5-hydroxytryptamine. It can also mobilize intracellular calcium to maintain tension.
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Cat. No.: HY-P1321
CAS No.: 158859-98-4
Synonyms: 1229U91; GW1229
Research Areas:  

Neurological Disease

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8) .
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Cat. No.: HY-P3593
CAS No.: 88280-21-1
LPLRF-NH2 is a member of RFamide peptide with anorexigenic effect. LPLRF-NH2 increases arterial blood pressure and modulates the electrical activity of brainstem neurons .
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Cat. No.: HY-P1915
CAS No.: 600171-68-4
Research Areas:  

Metabolic Disease

26Rfa, Hypothalamic Peptide, human is a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity . 26RFa is an orexigenic neuropeptide identified as the endogenous ligand of the orphan G protein-coupled receptor GPR103 .
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Cat. No.: HY-P2472
CAS No.: 600171-70-8
Synonyms: 26RFa (mouse, rat)
Research Areas:  

Metabolic Disease

Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27 .
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Cat. No.: HY-P3945
CAS No.: 209466-90-0
Research Areas:  

Neurological Disease

Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP). PrRP is RF-amide peptides expressed in brain areas involved in pain modulation. Prolactin-Releasing Peptide (12-31), bovine can be used for the research of nervous system disease .
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Cat. No.: HY-P1321A
Synonyms: 1229U91 TFA; GW1229 TFA
Research Areas:  

Neurological Disease

GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pKi= 8.8) .
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Cat. No.: HY-P11480
CAS No.: 3105660-96-3
Target:  

Trk Receptor

Research Areas:  

Neurological Disease

TrkA/NGF-IN-1 (Peptide 19) is an inhibitor of protein-protein interactions between TrkA and NGF (IC50: 21 nM for human TrkA in PathHunter assay). TrkA/NGF-IN-1 shows an analgesic effect in a rat incisional pain model .
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