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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
RNF126
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "RNF126" in MCE Product Catalog:
1
1 Cited Publications
Art. -Nr.: HY-175324
CAS. Nr.: 3098773-64-6
Forschungsgebiete:
MG-HuR2 is a molecular glue degrader targeting HuR (ELAVL1) with a Kd of 0.2018 μM. MG-HuR2 recruits the E3 ubiquitin ligase RNF126 and induces proteasome-dependent degradation of HuR. MG-HuR2 exhibits a unique biphasic degradation profile. MG-HuR2 reduces the expression of HuR and its downstream targets Bcl2/FOXQ1, inhibits breast cancer cell proliferation, enhances cytotoxicity and apoptosis (apoptosis), and suppresses the growth of 3D breast cancer tumor spheres. MG-HuR2 can be used in studies related to breast cancer and HuR-targeted protein degradation .
Art. -Nr.: HY-W854844A
CAS. Nr.: 3065021-33-9
Forschungsgebiete:
JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders .
Art. -Nr.: HY-RS12045
Target:
Forschungsgebiete:
RNF126 Human Pre-designed siRNA Set A contains three designed siRNAs for RNF126 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-RS20591
Target:
Forschungsgebiete:
Rnf126 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rnf126 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-170574
CAS. Nr.: 3093767-34-8
Target:
Forschungsgebiete:
CQ627 is a molecular glue degrader of right open reading frame kinase 2 (RIOK2). CQ627 inhibits the ATPase activity of RIOK2 in MOLT-4 cells with an IC50 of 98 nM. By recruiting the E3 ubiquitin ligase RNF126, CQ627 promotes RIOK2 ubiquitination and induces its degradation via the ubiquitin-proteasome system (UPS), while inhibiting RIOK2-dependent mTOR/AKT signaling, suppressing cancer cell proliferation, and inducing G2/M cell cycle arrest and apoptosis. CQ627 can be used in studies related to RIOK2-targeted protein degradation and leukemia .
Art. -Nr.: HY-RS27099
Target:
Forschungsgebiete:
Rnf126 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rnf126 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Art. -Nr.: HY-163639
CAS. Nr.: 3036530-43-2
Forschungsgebiete:
BRD4 degrader-2 (Compound JP-2-197) is a covalent monovalent molecular glue BRD4degrader that induces a ternary complex formation between BRD4 and RNF126. BRD4 degrader-2 targets RNF126 (E3 ligase) and degrades both the long and short isoforms of BRD4 in cells .
Art. -Nr.: HY-W854844B
Forschungsgebiete:
JP-2-196 hydrochloride is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 hydrochloride also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 hydrochloride induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride has potential for cancer research (such as prostate cancer and leukemia) .
Art. -Nr.: HY-177782
Target:
Forschungsgebiete:
SB1349 is a potent Lin28 molecular glues degrader, with DC50 values of 1.594 µM and 0.777 µM for Lin28A and Lin28B, respectively. SB1349 induces proteasome-dependent degradation by directly binding and recruiting the E3 ubiquitin ligase RNF126. SB1349 can be used for the study of neuroblastoma .
Art. -Nr.: HY-177732
Target:
Forschungsgebiete:
MG-Lin2 is a Lin28 molecular glue degrader. It induces the formation of a ternary complex between Lin28 and the E3 ubiquitin ligase RNF126, mediates the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the abundance and function of mature let-7 miRNA. MG-Lin2 can be used in studies of ovarian cancer and choriocarcinoma .
Art. -Nr.: HY-177733
Target:
Forschungsgebiete:
MG-Lin3 is a Lin28 molecular glue degrader. MG-Lin3 recruits the E3 ubiquitin ligase RNF126 to form a ternary complex, induces the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the levels of mature let-7 miRNA. MG-Lin3 can be used in research on ovarian cancer, ovarian teratocarcinoma, and uterine cancer .
Art. -Nr.: HY-187457
CAS. Nr.: 3036531-21-9
Forschungsgebiete:
J594 is a BRD4 molecular glue degrader targeting RNF126, with DC50 values of 0.077 μM (long-form BRD4 in HEK293T cells) and 0.26 μM (short-form BRD4 in HEK293T cells), respectively. J594 induces proteasome- and RNF126-dependent degradation of BRD4 .
Art. -Nr.: HY-187458
CAS. Nr.: 3105892-11-0
Forschungsgebiete:
EST1140 is a covalent molecular glue degrader targeting RNF126 for AR/AR-V7, with DC50 values of 33 μM and 30 μM, respectively, in 22Rv1 cells. EST1140 covalently binds to the E3 ligase RNF126 to achieve targeted protein degradation. EST1140 can be used in the research of androgen-independent prostate cancer .
Art. -Nr.: HY-W854844
CAS. Nr.: 2913587-30-9
Forschungsgebiete:
JP-2-196 is a molecular glue that covalently targets the RING family E3 ligase RNF126. JP-2-196 also binds to RNF40, MID2, RNF219, RNF14, and LRSAM1. JP-2-196 induces the formation of ternary complexes between RNF126 and target proteins (e.g., BRD4, AR-V7), thereby promoting their ubiquitination and proteasomal degradation. JP-2-196 has potential for cancer research (such as prostate cancer and leukemia) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
