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SRI

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Met/HGFR (1) CDK (1) CFTR (2) HuR (2) MMP (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (2)
By Research Areas:	Cancer (4) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (2)

15

Inhibitors & Agonists

1

Natural
Products

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SRI-37330	Others	Metabolic Disease
SRI-37330 is an orally active TXNIP inhibitor. SRI-37330 decreases glucagon secretion and action and blocks hepatic glucose output. SRI-37330 can be used in the research of obesity and diabetes .

SRI-37240	CFTR	Inflammation/Immunology
SRI-37240 is a potent premature termination codons (PTCs) inhibitor. SRI-37240 suppresses CFTR nonsense mutations. SRI-37240 alters cellular translation termination at PTCs in HEK293T cells. SRI-37240 can also restore CFTR function in primary bronchial epithelial cells when combination with G418 .

SRI-37330 hydrochloride	Others	Metabolic Disease
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research .

SRI-42127	HuR	Others
SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes .

SRI 37892	Others	Cancer
SRI 37892 is a small molecule compound inhibitor of Frizzled protein 7 (Fzd7) with inhibitory activity against cancer cell proliferation (IC₅₀2μM). SRI 37892 significantly blocks Wnt/Fzd7 signaling. SRI 3789 can be used in the research of developing cancer therapeutic agents [1].

SRI-41315	CFTR	Inflammation/Immunology
SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity .

SRI-011381 hydrochloride Maximum Cited Publications 31 Publications Verification	TGF-beta/Smad	Neurological Disease
SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

SRI-011381 Maximum Cited Publications 31 Publications Verification	TGF-beta/Smad	Neurological Disease
SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects .

SRI 31215 TFA	c-Met/HGFR	Cancer
SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC₅₀ values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .

HY-123600

SRI-29329

CDK Others

SRI-29329 is a specific CLK inhibitor, with IC₅₀ values of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively .

SRI-43265	HuR	Cancer
SRI-43265 (compound 40) is an inhibitor of human antigen R protein (HuR) dimerization, and HuR multimers have been implicated in cancer and inflammatory pathogenesis .

SRI 6409-94	Others	Others
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity .

SRI Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SRI Human Pre-designed siRNA Set A contains three designed siRNAs for SRI gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SRI Human Pre-designed siRNA Set A SRI Human Pre-designed siRNA Set A

HY-19956

GI254023X

5+ Cited Publications

GI4023; SRI028594
MMP Cancer

GI254023X is a potent MMP9 and ADAM10 inhibitor with IC₅₀s of 2.5 and 5.3 nM, respectively.

16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid	Others	Others
16R-Hydroxy-3-oxolanosta7,9(11),24-trien-21-oic acid is a lanostanoid that can be found in the Sri Lankan basidiomycete Ganoderma applanatum .

Species:	Human (3)
Tag:	His (1) Tag Free (1) GST (2)
Source:	Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	*Sorcin/SRI* Protein, Human (sf9, His-GST)** 22 kDa protein; CP22; V19	Human	Sf9 insect cells
	Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9, His-GST) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (sf9, His-GST) is 198 a.a., with molecular weight of ~47 kDa.

	*Sorcin/SRI* Protein, Human (sf9)** 22 kDa protein; CP22; V19	Human	Sf9 insect cells
	Sorcin/SRI protein, a calcium-binding modulator, intricately regulates excitation-contraction coupling in the heart and plays a crucial role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI exerts its influence on the activity of RYR2 calcium channels, contributing to the precise control of calcium dynamics in cardiac muscle cells. Its interactions with GCA, RYR2, and ANXA7 underscore its involvement in complex molecular networks, suggesting a multifaceted role in cellular processes related to calcium signaling and homeostasis. In the context of the heart, Sorcin/SRI emerges as a key player in the orchestration of calcium-dependent events, emphasizing its significance in the fine-tuning of excitation-contraction coupling and intracellular calcium regulation. Sorcin/SRI Protein, Human (sf9) is the recombinant human-derived Sorcin/SRI protein, expressed by Sf9 insect cells , with tag free. The total length of Sorcin/SRI Protein, Human (sf9) is 198 a.a., with molecular weight of ~20 kDa.

	*Sorcin/SRI* Protein, Human (E.coli, GST)** 22 kDa protein; CP22; V19	Human	E. coli
	The Sorcin/SRI protein is a calcium-binding regulator that complexly regulates excitation-contraction coupling in the heart and plays a critical role in maintaining calcium homeostasis within the sarcoplasmic reticulum. As a homodimer, Sorcin/SRI affects the activity of the RYR2 calcium channel, helping to precisely control calcium dynamics in cardiomyocytes. Sorcin/SRI Protein, Human (E.coli, GST) is the recombinant human-derived Sorcin/SRI protein, expressed by E. coli , with N-GST labeled tag. The total length of Sorcin/SRI Protein, Human (E.coli, GST) is 198 a.a., with molecular weight of ~48 kDa.

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