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Results for "

TEAD4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) c-Myc (1) IAP (1) Ligands for Target Protein for PROTAC (1) PROTACs (4) Small Interfering RNA (siRNA) (3) SNIPERs (2) YAP (14)
By Research Areas:	Cancer (13) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147136

MYF-03-176 1 Publications Verification	YAP	Cancer
MYF-03-176 is an orally active inhibitor of *TEAD, and suppresses TEAD* transcriptional activity with an IC₅₀ of 11 nM. The IC₅₀ values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model .

HY-125269

TED-347 Maximum Cited Publications 11 Publications Verification	YAP	Cancer
TED-347 is a potent, irreversible, covalent and allosteric inhibitor at *YAP-TEAD* protein-protein interaction with an EC₅₀** of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a K_i of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity .

HY-139330

MGH-CP1 1 Publications Verification	Apoptosis	Cancer
MGH-CP1 is a potent and orally active *TEAD2* and *TEAD4* auto-palmitoylation inhibitor with IC₅₀s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion .

HY-172113

H122	PROTACs YAP c-Myc Apoptosis	Cancer
H122 is a PROTAC degrader for *TEAD* that degrades TEAD1 with a DC₅₀ of 3 nM. H122 exhibits good affinity to *TEAD2, TEAD3, and TEAD4* with K_i values of 2.0, 3.6 and 1.6 nM, respectively. H122 relies on binding to TEAD1 and CRBN, functional E3 ligase activity, and a functional proteasome for degradation.H122 induces degradation of TEAD3 and forms a ternary complex with TEAD4 and CRBN/DDB1 to mediate degradation.H122 downregulates expression of Myc target genes. H122 exhibits antitumor efficacy in MSTO-211H mouse xenograft models.H122 can be used for the research of malignant mesothelioma .

HY-147135

MYF-03-69 1 Publications Verification TEAD-IN-3	YAP Apoptosis	Cancer
MYF-03-69 (TEAD-IN-3) is a covalent and irreversible *TEAD* inhibitor with IC₅₀s of 385, 143, 558 and 173 nM for *TEAD1, TEAD2, TEAD3* and *TEAD4. MYF-03-69 disrupts YAP-TEAD* association, suppresses TEAD transcriptional activity (IC₅₀ = 56 nM) and up-regulates apoptosis gene BMF. MYF-03-69 selectively inhibits mesothelioma cancer cells with defective Hippo signaling. MYF-03-69 can be used for the study of malignant pleural mesothelioma (MPM) .

HY-RS14345

TEAD4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TEAD4 Human Pre-designed siRNA Set A contains three designed siRNAs for TEAD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TEAD4 Human Pre-designed siRNA Set A TEAD4 Human Pre-designed siRNA Set A

HY-RS16870

Tead4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tead4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tead4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tead4 Mouse Pre-designed siRNA Set A Tead4 Mouse Pre-designed siRNA Set A

HY-RS23311

Tead4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Tead4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tead4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tead4 Rat Pre-designed siRNA Set A Tead4 Rat Pre-designed siRNA Set A

HY-172932

TEAD-IN-20	YAP	Cancer
TEAD-IN-20 is a *TEAD* inhibitor. The IC₅₀ values of TEAD-IN-20 in TEAD4 FRET and TEAD4 MCF7-Tead cell lines are 0.021 and 0.044 μM, respectively. TEAD-IN-20 can be used in cancer research .

HY-160657

DC-TEADin04	YAP	Others
DC-TEADin04 has weak inhibitory activity against TEAD4 palmitoylation .

HY-173139

TEAD-IN-19	YAP	Cancer
TEAD-IN-19 (Compound 1l) is a transcriptional inhibitor of *TEAD, exhibiting inhibition rates of 38.5%, 36.2%, 57.8%, and 71.3% against TEAD1, TEAD2, TEAD3, and TEAD4, respectively, at a concentration of 10 μM. TEAD-IN-19 shows potent anti-proliferative and anti-migratory activities in prostate cancer cell lines and significantly reduces the expression of TEAD-regulated downstream genes. TEAD*-IN-19 holds promise for research in the field of cancer therapy .

HY-179706

VS3	YAP	Cancer
VS3 is a *YAP-TEAD* interaction inhibitor. VS3 directly disrupts the interaction between YAP-TEAD by binding to TEAD4 Interface 3 (K_d = 6 μM) on the surface. VS3 exhibits anti-proliferative activity against HT29, HCT116, and A2780. VS3 can be used for research on colorectal adenocarcinoma and ovarian cancer .

HY-183753

LC-TD-05	YAP Apoptosis	Cancer
LC-TD-05 is a non-covalent inhibitor of *TEAD1, TEAD2* and *TEAD4, with IC₅₀* values of 116.6 nM, 168.7 nM and 68.3 nM, respectively; it shows weak activity against *TEAD3, with a human IC₅₀* of 1261.0 nM. LC-TD-05 induces apoptosis in hepatocellular carcinoma cells. LC-TD-05 can be used for the research of hepatocellular carcinoma .

HY-186117

KG-FP-003	YAP PROTACs	Cancer
KG-FP-003 is a highly potent, selective, and durable *TEAD* PROTAC degrader (TEAD1 DC₅₀ = 6 ± 4 nM, TEAD2 DC₅₀ = 68 ± 15 nM, TEAD3 DC₅₀ = 12 ± 5 nM, TEAD4 DC₅₀ = 7 ± 5 nM). KG-FP-003 promotes ubiquitination and degradation of TEAD. KG-FP-003 exhibits anticancer activity against mesothelioma and ovarian cancer .

HY-181594

*PROTAC TEAD/IAP degrader-1*	PROTACs SNIPERs YAP	Cancer
PROTAC TEAD/IAP degrader-1 is a *TEAD/IAP* PROTAC degrader. PROTAC TEAD/IAP degrader-1 is also a specific and Nongenetic inhibitor of apoptosis protein (IAP)-dependent protein eraser (SNIPERs). PROTAC TEAD/IAP degrader-1 recruits cIAP1 to form ternary complexes, induces ubiquitination, proteasomal *TEAD1, TEAD4* degradation. PROTAC TEAD/IAP degrader-1 inhibits TEAD transcriptional activity, reduces CTGF expression, and reduces cell proliferation. PROTAC TEAD/IAP degrader-1 can be used for the research of mesothelioma .

HY-147209

*DC-TEAD3in03*	YAP	Metabolic Disease
DC-TEAD3in03 is a subtype-selective and covalent *TEAD3* inhibitor with an IC₅₀ of 0.16 μM. DC-TEAD3in03 exhibits the inhibitory activity on TEAD1/2/4 reduced by more than 100 times. DC-TEAD3in03 has the IC₅₀ for TEAD3 of 1.15 μM in the GAL4-TEAD reporter gene experiment in cells, and it does not interfere with the β-catenin pathway. DC-TEAD3in03 reduces the growth rate of the zebrafish tail fin. DC-TEAD3in03 can be used to study the proportional growth of appendages in vertebrates .

HY-181534

*PROTAC TEAD1/IAP degrader-1*	PROTACs YAP IAP SNIPERs	Cancer
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

HY-186118

TEAD ligand 6	Ligands for Target Protein for PROTAC YAP	Neurological Disease Cancer
TEAD ligand 6 is a *TEAD* ligand. TEAD ligand 6 serves as a ligand for target protein for PROTAC (Ligands for Target Protein for PROTAC) and is used to develop and design PROTAC-based TEAD degraders, such as KG-FP-003 (HY-186117). TEAD ligand 6 applies to glioblastoma research .

Species:	Human (1) Mouse (2)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71535

	TEAD4 Protein, Human (His) EFTR 2; EFTR2; hRTEF 1B; hRTEF1B; TEAD 4; TEAD-4; TEAD4; TEAD4_HUMAN; TEF 3; TEF3; TEFR 1; TEFR1; Transcription factor 13 (SV40 transcriptional enhancer factor) like 1; Transcription factor 13 like 1; Transcription factor 13-like 1; Transcription factor RTEF 1; Transcription factor RTEF-1; Transcription factor RTEF1; Transcriptional enhancer factor 1 related; Transcriptional enhancer factor 3	Human	E. coli
	TEAD4 protein is a transcription factor that plays a key role in the Hippo signaling pathway and is essential for organ size control and tumor suppression. It coordinates proliferation inhibition and apoptosis promotion through a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1. TEAD4 Protein, Human (His) is the recombinant human-derived TEAD4 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P71575

	*ETFR-2/TEAD-4* Protein, Mouse** 2 Publications Verification ETF-related factor 2; ETFR-2; TEA domain family member 4; TEAD-4; TEF-1-related factor 1; TEF-1-related factor FR-19; RTEF-1	Mouse	E. coli
	ETFR-2/TEAD-4 protein is a key transcription factor that tightly regulates the Hippo signaling pathway and is an integral component of organ size control and tumor suppression. In this pathway, it mediates a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1, leading to the inactivation of YAP1 and WWTR1/TAZ. ETFR-2/TEAD-4 Protein, Mouse is the recombinant mouse-derived ETFR-2/TEAD-4 protein, expressed by E. coli , with tag free.

HY-P705510

	*ETFR-2/TEAD-4* Protein, Mouse (His)** ETF-related factor 2; ETFR-2; TEA domain family member 4; TEAD-4; TEF-1-related factor 1; TEF-1-related factor FR-19; RTEF-1	Mouse	E. coli
	ETFR-2/TEAD-4 protein is a key transcription factor that tightly regulates the Hippo signaling pathway and is an integral component of organ size control and tumor suppression. In this pathway, it mediates a kinase cascade involving MST1/MST2, SAV1, LATS1/2, and MOB1, leading to the inactivation of YAP1 and WWTR1/TAZ. ETFR-2/TEAD-4 Protein, Mouse is the recombinant mouse-derived ETFR-2/TEAD-4 protein, expressed by E. coli , with His tag.

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HY-P82377

	*TEF1/TEAD-1 Antibody (YA2122)* DTEF 1; NTEF 1; TCF13; TEAD1; TEAD2; TEAD3; TEAD4; TEAD5; TEF1; TEF4; TEF5	WB	Human
	TEF1/TEAD-1 Antibody (YA2122) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TEF1/TEAD-1.

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HY-181534

*PROTAC TEAD1/IAP degrader-1*		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and cIAP1 PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the *TEAD*-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma .

TEAD4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TEAD4 Human Pre-designed siRNA Set A contains three designed siRNAs for TEAD4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tead4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tead4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tead4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tead4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Tead4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Tead4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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