Search Result

Results for "

Taxane

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Apoptosis (7) Aurora Kinase (1) Autophagy (1) Biochemical Assay Reagents (1) c-Myc (1) Caspase (1) CD276/B7-H3 (1) Drug Derivative (5) Drug Metabolite (1) Endogenous Metabolite (1) Ferroptosis (1) FGFR (1) HIF/HIF Prolyl-Hydroxylase (1) JNK (1) LDLR (1) Microtubule/Tubulin (12) Oct3/4 (1) p38 MAPK (1) Peptide-Drug Conjugates (PDCs) (1) PERK (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2)
By Research Areas:	Cancer (26) Cardiovascular Disease (1) Metabolic Disease (1)

By Targets:

ADC Antibody (1)

Apoptosis (7)

Aurora Kinase (1)

Autophagy (1)

Biochemical Assay Reagents (1)

c-Myc (1)

Caspase (1)

CD276/B7-H3 (1)

Drug Derivative (5)

Drug Metabolite (1)

Endogenous Metabolite (1)

Ferroptosis (1)

FGFR (1)

HIF/HIF Prolyl-Hydroxylase (1)

JNK (1)

LDLR (1)

Microtubule/Tubulin (12)

Oct3/4 (1)

p38 MAPK (1)

Peptide-Drug Conjugates (PDCs) (1)

PERK (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (2)

By Research Areas:

Cancer (26)

Cardiovascular Disease (1)

Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99974

Nab-Paclitaxel 4 Publications Verification Nanoparticle albumin-bound Paclitaxel; Nanoparticle albumin-bound ABI-007	Microtubule/Tubulin Apoptosis Autophagy	Cancer
Nab-Paclitaxel (Nanoparticle albumin-bound Paclitaxel) is an albumin-bound nanoparticle formulation of Paclitaxel (HY-B0015). Nab-Paclitaxel is composed of albumin and the active pharmaceutical ingredient Paclitaxel, in which human albumin is used as an excipient to disperse and stabilize particles and carry the main drug. Nab-Paclitaxel is a solvent-free taxane with higher response rates and improved tolerability. Nab-Paclitaxel displays less toxicity and greater antitumor activity. Nab-Paclitaxel is more readily available for tumor cell uptake in three rhabdomyosarcoma, seven neuroblastoma cell lines, and one ostersarcoma cell line Nab-Paclitaxel can be studied in cancer research for example breast cancer and solid tumors. (The product specifications below only indicate the effective content of Paditaxel, the actual albumin quality depends on the batch; the ratio of each ingredient in this product is Paditaxel: albumin -1:7~1:11) .

HY-P4073

ANG1005 GRN1005; Paclitaxel trevatide	Peptide-Drug Conjugates (PDCs) LDLR	Cancer
ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .

HY-137377

TAS-119 1 Publications Verification	Aurora Kinase	Cancer
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC₅₀ of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC₅₀ of 95 nM). TAS-119 has potent antitumor activites .

HY-P99740

Mirzotamab	CD276/B7-H3 ADC Antibody	Cancer
Mirzotamab is an IgG1κ monoclonal antibody targeting to CD276/B7-H3 with anti-tumor activity. Mirzotamab conjugates with Clezutoclax (HY-137774), a BCL inhibitor to form Mirzotamab clezutoclax (HY-P99741), involving in research with taxane research in relapsed/refractory solid tumors. Mirzotamab clezutoclax (ABBV-155) is a targeted antibody drug conjugate (ADC) .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Microtubule/Tubulin	Cancer
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-16187

EL-102	HIF/HIF Prolyl-Hydroxylase Apoptosis	Cancer
EL-102 is a hypoxia-induced factor 1 (Hif1α) inhibitor. EL-102 induces apoptosis, inhibits tubulin polymerisation and shows activities against prostate cancer. EL-102 can be used for the research of cancer .

HY-125374

Larotaxel XRP9881	Apoptosis	Cancer
Larotaxel (XRP9881) is a taxane analogue with preclinical activity against taxane-resistant breast cancer. Larotaxel (XRP9881) exerts its cytotoxic effect by promoting tubulin assembly and stabilizing microtubules, ultimately leading to cell death by apoptosis. It presents the ability to cross the blood brain barrier and has a much lower affinity for P-glycoprotein 1 than Docetaxel .

HY-121524

DJ101	Microtubule/Tubulin	Cancer
DJ101 is a potent and metabolically stable tubulin inhibitor. DJ101 targets the colchicine binding site and overcomes taxane resistance. DJ101 also inhibits melanoma tumor growth and lung metastasis. DJ101 can be used for prostate cancer research .

HY-133194

Taxinine M	Others	Others
Taxinine M, a tetracyclic taxane, can be isolated from Taxus brevifolia .

HY-165606

SB-T-1214	Oct3/4 c-Myc Apoptosis	Cancer
SB-T-1214 (SBT) is a taxane. SB-T-1214 efficiently inhibits expression of stem cell-related genes (Oct4, Sox2, and c-Myc) and induces apoptosis of colon cancer spheroids with drug resistant tumorigenic CD133 ⁺/CD44 ⁺ cells. SB-T-1214 strongly represses tumor growth in Pgp+ DLD-1 human colon tumor xenografts mice model. SB-T-1214 can be used for antitumor research, especially against tumors with drug resistance, such as colon, pancreatic and renal cancers .

HY-106159

SB-T-101141	Reactive Oxygen Species (ROS) p38 MAPK JNK PERK Ferroptosis	Cancer
SB-T-101141 is a novel taxane. SB-T-101141 effectively induces a noncanonical ferroptosis to overcome Paclitaxel (HY-B0015) resistance of breast cancer. SB-T-101141 facilitates the production of iron and ferrous ions and ROS. SB-T-101141 stably binds to KHSRP to inhibit the iron-dependent expression of CISD1 related to iron homeostasis. SB-T-101141 synergistically enhances the iron-dependent activation of JNK and PERK pathways via KHSRP. SB-T-101141 suppresses breast tumor growth in MCF-7(PR)/MDA-MB-231(PR) or KHSRP knock-down MCF-7 xenograft mice model .

HY-16491

Tesetaxel DJ-927	Microtubule/Tubulin	Cancer
Tesetaxel (DJ-927) is an orally active and brain-penetrant taxane tubulin inhibitor. Tesetaxel inhibits tubulin depolymerization with an IC₅₀ of 0.44 μM. Tesetaxel inhibits cancer cells proliferation and shows potent antitumor activity against P-glycoprotein-positive cancer cells. Tesetaxel can be used for the research of cancer, such as solid tumors, liver metastasis, and advanced breast cancer .

HY-175555

Tubulin-IN-54	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-54 is a tubulin inhibitor. Tubulin-IN-54 exhibits anti-proliferative activity against various cancer cells. Tubulin-IN-54 inhibits tubulin polymerization, disrupts microtubule networks, induces G2/M cell cycle arrest, and promotes cancer cell apoptosis. Tubulin-IN-54 demonstrates significant anti-tumor efficacy in mice bearing PC-3/TxR xenografts. Tubulin-IN-54 can be used for the study of taxane-resistant cancers (prostate cancer, melanoma) .

HY-N8266

10-Deacetylcephalomannine 10-Deacetyltaxol B	Others	Others
10-Deacetylcephalomannine is a taxane that can be isolated from the bark of Taxus baccata L. .

HY-N8070

13-O-Cinnamoylbaccatin III Baccatin III 13-cinnamate	Drug Derivative	Others
13-O-Cinnamoylbaccatin III (Baccatin III 13-cinnamate) is a taxane that can be found in the twigs of Taxus mairei .

HY-N7483

1-Dehydroxybaccatin IV	Others	Metabolic Disease
1-Dehydroxybaccatin IV is a taxane diterpene. 1-Dehydroxybaccatin IV shows concentration-dependent NO inhibition, with an IC₅₀ of 32.2 μM .

HY-W778562

10-Deacetyl-13-oxobaccatin III	Others	Cancer
10-Deacetyl-13-oxobaccatin III is an taxane that can be isolated from Taxus sumatrana. 10-Deacetyl-13-oxobaccatin III (30 μg/mL) shows cytotoxicity against A498, NCI-H226, A549, PC-3 cells, with inhibition a rate of 29.7%, 49.2%, 43.9%, 65.3% .

HY-111251

4SC-207	Microtubule/Tubulin Apoptosis	Cancer
4SC-207 is a potent, orally active microtubule inhibitor. 4SC-207 inhibits microtubule growth to inhibit tumor cell proliferation in vitro and in vivo, and promotes a mitotic delay/arrest, followed by apoptosis or aberrant divisions. 4SC-207 inhibits tumor growth in taxane resistant xenograft mouse models. 4SC-207 can be used for cancer research, such as colon adenocarcinoma and other malignancies .

HY-N7366

Taxachitriene A	Others	Others
Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .

HY-126655

Yunnanxane	Others	Others
Yunnanxane (compound 1) is a taxane diterpenoid that can be found in Taxus chinensis var. .

HY-N9043

Tasumatrol L	Others	Others
Tasumatrol L (compound 5) is a 21-carbon taxane ester that can be found in Taxus sumatrana .

HY-119214

TL-310	Drug Derivative	Cancer
TL-310 is a novel, orally active Taxane analogue. TL-310 can be used in the research of solid tumors .

HY-125374A

Larotaxel dihydrate XRP9881 dihydrate	Microtubule/Tubulin	Cancer
Larotaxel (dihydrate) (XRP9881 (dihydrate)), a new taxane compound prepared by partial synthesis from 10-deacetyl baccatin III, is active against tumors .

HY-162594

Antitumor agent-164	Microtubule/Tubulin	Cancer
Antitumor agent-164 (compound 60c) is a colchicine-binding site inhibitor (CBSI) with potency against taxane-sensitive TNBC. Antitumor agent-164 is a next-generation derivative of VERU-111 .

HY-13684

Milataxel MAC-321	Drug Derivative Microtubule/Tubulin	Cancer
Milataxel (MAC-321) is an orally active taxane analog of Docetaxel (HY-B0011). Milataxel enhances the rate of tubulin polymerization. Milataxel can be used in the research of colorectal cancer and non-small cell lung cancer .

HY-N12004

19-Hydroxy-10-deacetylbaccatin III	Others	Cancer
19-Hydroxy-10-deacetylbaccatin III (compound 13) is a taxane with potential antitumor activity. 19-Hydroxy-10-deacetylbaccatin III has weak cytotoxicity against A498 and NCI-H226 cell lines. The study found that the inhibition rates of 30 μg/mL 19-Hydroxy-10-deacetylbaccatin III on A498, NCI-H226 and PC-3 were 16.6% and 32% respectively .

HY-N1391R

10-Deacetyltaxol (Standard) 10-Deacetylpaclitaxel (Standard)	Reference Standards Microtubule/Tubulin	Cancer
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N0060AR

Ferulic acid sodium (Standard) Coniferic acid sodium (Standard)	Reference Standards FGFR Endogenous Metabolite Reactive Oxygen Species (ROS)	Cardiovascular Disease Cancer
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-175981

Paclitaxel-bromothiophene	Drug Derivative	Cancer
Paclitaxel-bromothiophene is a semisynthetic taxane analogue of Paclitaxel (HY-B0015). Paclitaxel-bromothiophene exhibits potent antiproliferative activity against 4-T1 breast cancer cells, with an IC₅₀ value of 15.18 nM. Paclitaxel-bromothiophene shows high binding affinity to C5aR1 (K_d = 19.4 μM). Paclitaxel-bromothiophene demonstrates excellent anti-tumor efficacy in 4-T1 breast cancer-bearing mice. Paclitaxel-bromothiophene can be used for the study of breast cancer .

HY-N1173

Taxayuntin Taxayunnansin A; 13-Decinnamoyltaxchinin B	Others	Others
Taxayuntin (Taxayunnansin A; 13-Decinnamoyltaxchinin B) is a taxane diterpenoid isolated from Taxus yunnanensis .

HY-120120

DZ-2384	Microtubule/Tubulin	Cancer
DZ-2384 is a potent microtubule-targeting agent. DZ-2384 increases the rescue frequency and preserves the microtubule network in nonmitotic cells and primary neurons. DZ-2384 acts synergistically with anti-CTLA-4 immunotherapy in Taxane-sensitive and Taxane-resistant xenograft murine models of triple-negative breast cancer (TNBC). DZ-2384 exhibits potent antitumor activity in adult acute lymphocytic leukemia (ALL) models. DZ-2384 can be used for cancer research, such as TNBC and ALL ^[1][2].

HY-16457

Simotaxel MST 997	Microtubule/Tubulin Caspase Apoptosis	Cancer
Simotaxel (MST 997) is an orally active derivative of the taxane class. Simotaxel binds to β-tubulin and promotes tubulin polymerization (EC₅₀ = 0.9 μM), inhibits tubulin depolymerization, and causes cell cycle arrest at the G₂-M phase. Simotaxel disrupts the formation of the mitotic spindle and triggers the caspase-dependent apoptotic pathway (apoptosis). Simotaxel has inhibitory effects on Paclitaxel (HY-B0015) sensitive cell lines and overcomes drug resistance. Simotaxel can be used to study Paclitaxel / Docetaxel (HY-B0011) resistant solid tumors .

HY-106185

BMS-188797	Drug Derivative	Cancer
BMS-188797 is a novel Taxane analog. BMS-188797 enhances the efficacy of radiotherapy against lung cancer .

HY-E71178

10-Hydroxytaxane O-acetyltransferase	Biochemical Assay Reagents	Others
10-Hydroxytaxane O-acetyltransferase (EC 2.3.1.163) acts on a number of related taxane diterpenoids with a free 10β-hydroxy group.

HY-185226

γ-Linolenic acid NHS ester	Drug Metabolite	Cancer
γ-Linolenic acid NHS ester is a lipid metabolite of γ-Linolenic acid (GLA) (HY-N7140), which can serve as a synthetic intermediate or probe labeling reagent for the preparation of GLA conjugates. In practical applications, γ-Linolenic acid NHS ester can be conjugated with *taxanes* and polysaccharides to form dual-type conjugates for drug delivery purposes .

Cat. No.	Product Name	Target	Research Area