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Type I allergic

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By Targets:	Bacterial (1) Cholinesterase (ChE) (1) Drug Derivative (1) Glycosidase (1) Histamine Receptor (1) Interleukin Related (1) MMP (1) STAT (1) TNF Receptor (2)
By Research Areas:	Infection (1) Inflammation/Immunology (7) Neurological Disease (1)

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Targets Recommended: C-type Lectin-like Receptors (CTLRs) PCSK9 Scavenger Receptor Class B type I (SR-BI）

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-177456

STAT6 degrader-3	STAT	Inflammation/Immunology
STAT6 degrader-3 (Compound I-1) is a potent and selective STAT6 degrader with a DC₅₀ of <1 nM. STAT6 degrader-3 can be used in the research of Type 2 immune and allergic responses .

HY-N15663

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate EGCG4′′Me	Drug Derivative	Inflammation/Immunology
(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic .

HY-N1151

Thunberginol C	Bacterial Cholinesterase (ChE) MMP TNF Receptor	Infection Neurological Disease Inflammation/Immunology
Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC₅₀ values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety .

HY-N15708

Dichotomine C (R)-(-)-Dichotomine C	Glycosidase TNF Receptor Interleukin Related	Inflammation/Immunology
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

HY-119681

YM 11124	Others	Inflammation/Immunology
YM 11124 is an orally active selective immunosuppressive agent. YM 11124 can inhibit cell-mediated immune responses (type IV allergic reactions, such as delayed-type hypersensitivity and allogenic skin graft rejection) and type III allergic reactions (such as passive Arthus reaction). YM 11124 has no effect on type I, type II allergic reactions or acute inflammation. YM 11124 can be used in research related to organ transplantation and immune hypersensitivity .

HY-N15718

Dichotomine D	Others	Inflammation/Immunology
Dichotomine D is a β-carboline alkaloid found in the roots of Stellaria dichotoma. Dichotomine D acts as an antiallergic agent. Dichotomine D is promising for research of type I allergic reactions .

HY-107062

AA 344	Histamine Receptor	Inflammation/Immunology
AA 344 is an orally active antiallergic agent. AA 344 inhibits the IgE, IgGa, Concanavalin A (HY-P2149), Dextran -mediated release of histamine. AA 344 shows inhibitory effects on the homologous passive cutaneous anaphylaxis and the passive systemic anaphylaxis in guinea pigs. AA 344 selectively suppresses the type I allergic reaction .

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate EGCG4′′Me	Structural Classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Source Classification Theaceae	Drug Derivative
(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic .

Thunberginol C	Structural Classification Hydrangeaceae Coumarins Phenylpropanoids Plants Source Classification	Bacterial Cholinesterase (ChE) MMP TNF Receptor
Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC₅₀ values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety .

Dichotomine C (R)-(-)-Dichotomine C	Alkaloids Stellaria dichotoma L. Plants Caryophyllaceae Indole Alkaloids Source Classification	Glycosidase TNF Receptor Interleukin Related
Dichotomine C ((R)-(-)-Dichotomine C) is a β-carboline-type alkaloid with antiallergic effects. Dichotomine C inhibits the release of β-hexosaminidase in RBL-2H3 cells with an IC₅₀ of 62 μM. Dichotomine C inhibits the releases of antigen-IgE-mediated TNF-α and IL-4 in RBL-2H3 cells with IC₅₀s of 19 μM and 15 μM, respectively. Dichotomine C can be used for the study of type I allergic reactions .

Dichotomine D	Alkaloids Stellaria dichotoma L. Plants Caryophyllaceae Indole Alkaloids Source Classification	Others
Dichotomine D is a β-carboline alkaloid found in the roots of Stellaria dichotoma. Dichotomine D acts as an antiallergic agent. Dichotomine D is promising for research of type I allergic reactions .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Type I allergic

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