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Results for "

VCP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	p97 (16) ADC Linker (3) ADC Payload (1) Adenosine Receptor (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (1) Autophagy (1) Beclin1 (1) Caspase (1) Drug Derivative (1) Drug-Linker Conjugates for ADC (2) EGFR (1) Microtubule/Tubulin (1) p62 (1) Reactive Oxygen Species (ROS) (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (18) Inflammation/Immunology (2) Neurological Disease (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Fluorescent Dye

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: p97

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12861

CB-5083 Maximum Cited Publications 47 Publications Verification	p97	Cancer
CB-5083 is a first-in-class, potent, selective, and orally bioavailable inhibitor of the p97 AAA ATPase/VCP. CB-5083 selectively inhibits p97 through its D2 site with the IC₅₀ of 11 nM .

HY-15713

NMS-873 15+ Cited Publications	p97	Cancer
NMS-873 is a potent, selective allosteric *VCP/p97* inhibitor with an IC₅₀ value of 30 nM.

HY-128870

*Mal-PEG2-VCP-Eribulin*	Drug-Linker Conjugates for ADC	Cancer
Mal-PEG2-VCP-Eribulin consists the ADCs linker (Mal-PEG2-VCP) and Eribulin (HY-13442). Eribulin is a mechanistically unique microtubule inhibitor and Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules. Mal-PEG2-VCP-Eribulin is an Eribulin-based agent for antibody conjugates .

HY-123872

MSC1094308 1 Publications Verification	p97	Cancer
MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC₅₀ values of 0.71 μM and 7.2 μM for VPS4B and p97, respectively . MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer .

HY-130084

*Mal-PEG2-VCP-NB*	ADC Linker	Cancer
Mal-PEG2-VCP-NB is a claevable ADC linker containing a Maleimide group, 2-unit PEG and a VCP NB.

HY-157508

VCP Activator 1 2 Publications Verification	p97	Others
VCP Activator 1 is a *VCP* activator that dose-dependently stimulates VCP ATPase activity. VCP Activator 1 binds an allosteric pocket near the C-terminus. In addition, VCP Activator 1 binding site can also be occupied by a phenylalanine residue in the VCP C-terminal tail .

HY-15714

NMS-859 1 Publications Verification	p97	Cancer
NMS-859 is a potent, covalent VCP (p97) inhibitor, with IC₅₀s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.

HY-168324

UP158	p97	Others
UP158 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 2.57 μM .

HY-138233

KUS121	p97	Neurological Disease Inflammation/Immunology
KUS121, a *valosin-containing protein (VCP, p97)* modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress .

HY-168325

UP12	p97	Others
UP12 is an ATPase activity activator that activates the ATPase activity of valosin-containing protein (VCP), with an EC₅₀ of 1.24 μM. UP12 is applicable to research related to multisystem proteinopathies .

HY-139606

VCP/p97 inhibitor-1	p97	Cancer
VCP/p97 inhibitor-1 is a potent inhibitor of *VCP/p97* (also called Cdc48, CDC-. 48, or Ter94) with an IC₅₀ of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS) .

HY-RS15621

VCP Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VCP Human Pre-designed siRNA Set A contains three designed siRNAs for VCP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VCP Human Pre-designed siRNA Set A VCP Human Pre-designed siRNA Set A

HY-168323

UP163	p97	Others
UP163 enhances the activity of ATPase, and activates valosin-containing protein (VCP) with an EC₅₀ of 9.0 μM. UP163 reduces MG-132 (HY-13259)-induced TDP-43 aggregates .

HY-128871

VCP-Eribulin	Drug-Linker Conjugates for ADC	Cancer
VCP-Eribulin is a bioactive molecule-linker conjugate designed for ADCs (Drug-Linker Conjugates for ADC), formed by conjugating an ADC linker (VCP) with Eribulin (HY-13442). Eribulin is a unique microtubule inhibitor exhibiting antitumor activity. VCP-Eribulin can be utilized for antibody conjugation .

HY-124776

NPD8733	p97	Cancer
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 specifically binds to valosin-containing protein (VCP)/p97, a member of the ATPase-associated with diverse cellular activities (AAA+) protein family. NPD8733 has the potential for the research of cancer diseases .

HY-148122

NW 1028	p97	Cancer
NW 1028 is a potent *VCP/p97* inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with K_d values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells .

HY-174984

VCP/p97 IN-3	p97 Caspase p62	Cancer
VCP/p97 IN-3 is a *VCP/p97* allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC₅₀ of 9 nM and the mutant VCP proteins with IC₅₀ of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma .

HY-RS15623

Vcp Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vcp Rat Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vcp Rat Pre-designed siRNA Set A Vcp Rat Pre-designed siRNA Set A

HY-113608

VCP171	Adenosine Receptor	Neurological Disease
VCP171 is a potent adenosine A1 receptor (A1R) positive allosteric modulator (PAM). VCP171 is effective at decreasing excitatory synaptic currents in Lamina II of neuropathic pain model. VCP171 can be used for researching neuropathic pain .

HY-174847

VCP/p97 IN-2	p97	Cancer
VCP/p97 IN-2 (Compound V13) is a *VCP/p97* inhibitor with IC₅₀ of 32 nM for p97. VCP/p97 IN-2 has excellent antitumor activities and significantly inhibits tumor growth in Molm-13 xenograft mice model. VCP/p97 IN-2 can be used for acute myeloid leukemia (AML) research .

HY-160981

*Mal-PEG4-VCP-NB*	ADC Linker	Cancer
Mal-PEG4-VCP-NB (Compound 17) is a degradable ADC linker containing a maleimide group, 4 PEG units and VCP NB .

HY-177549

*Fmoc-PEG6-VCP-Eribulin*	Drug Derivative ADC Payload Microtubule/Tubulin Apoptosis	Cancer
Fmoc-PEG6-VCP-Eribulin is the derivative of Eribulin (HY-13442). Eribulin (E7389) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules .

HY-177414

BB-1701	Antibody-Drug Conjugates (ADCs) EGFR	Inflammation/Immunology Cancer
BB-1701 is an anti-HER2 antibody-drug conjugate (ADC). BB-1701 is composed of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), a microtubule inhibitor (Eribulin) (HY-13442), and the drug-linker conjugate for ADC is Mal-PEG2-VCP-Eribulin (HY-128870). BB-1701 has a potent cytotoxicity and bystander effects on tumors with heterogeneous target expression. BB-1701 significantly induces immunogenic cell death and the activation of the immune .

HY-160982

*Mal-PEG3-VCP-NB*	ADC Linker	Cancer
Mal-PEG3-VCP-NB (Compund 25c) is a degradable ADC linker containing a maleimide group, 3-unit PEG and VCP NB .

HY-RS15622

Vcp Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vcp Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vcp gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vcp Mouse Pre-designed siRNA Set A Vcp Mouse Pre-designed siRNA Set A

HY-118460

ACJI-99C VCP/p97-IN-PPA	p97	Cancer
ACJI-99C (VCP/p97-IN-PPA) is a selective covalent *p97/VCP* ATPase inhibitor with an IC₅₀ value of 0.6 μM. ACJI-99C binds with p97 active site residues to block ATPase activity. ACJI-99C irreversibly blocks degradation of p97-dependent protein in cells. ACJI-99C inhibits proliferation of cancer cells, including p97 inhibitor-resistant lines. ACJI-99C can be used for the research of colorectal cancer .

HY-183257

ATI-1	Autophagy Beclin1 Reactive Oxygen Species (ROS) p97	Cancer
ATI-1 is an autophagy initiation inhibitor. ATI-1 targets valosin-containing protein (VCP/p97, disrupts its interaction with UFL1, impairs UFMylation homeostasis associated with VCP, promotes polyubiquitination and degradation of Beclin1, and blocks the formation of early autophagosomes. ATI-1 induces synergistic death of autophagy-dependent malignant tumor cells under nutrient deprivation conditions, accompanied by decreased mitochondrial membrane potential, reduced ROS levels and lysosomal stress. ATI-1 exhibits anti-tumor efficacy in a pancreatic adenocarcinoma xenograft mouse model. ATI-1 can be used for the research of pancreatic adenocarcinoma and lung cancer .

Cat. No.	Product Name	Type

HY-177414

BB-1701	Fluorescent Dye
BB-1701 is an anti-HER2 antibody-drug conjugate (ADC). BB-1701 is composed of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), a microtubule inhibitor (Eribulin) (HY-13442), and the drug-linker conjugate for ADC is Mal-PEG2-VCP-Eribulin (HY-128870). BB-1701 has a potent cytotoxicity and bystander effects on tumors with heterogeneous target expression. BB-1701 significantly induces immunogenic cell death and the activation of the immune .

BB-1701

Fluorescent Dye

BB-1701 is an anti-HER2 antibody-drug conjugate (ADC). BB-1701 is composed of a humanized anti-HER2 antibody (Trastuzumab) (HY-P9907), a linker (Mal-PEG2-VCP), a microtubule inhibitor (Eribulin) (HY-13442), and the drug-linker conjugate for ADC is Mal-PEG2-VCP-Eribulin (HY-128870). BB-1701 has a potent cytotoxicity and bystander effects on tumors with heterogeneous target expression. BB-1701 significantly induces immunogenic cell death and the activation of the immune .

Species:	Human (4)
Tag:	His (2) Tag Free (1) GST (1)
Source:	HEK293 (1) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705508

	VCP Protein, Human (sf9, GST) Transitional Endoplasmic Reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 Subunit; Valosin-Containing Protein; VCP	Human	Sf9 insect cells
	VCP proteins are indispensable for Golgi stack dynamics, coordinating fragmentation during mitosis and postmitotic reorganization. It actively promotes the formation of the transitional endoplasmic reticulum (tER), enables ATP-dependent vesicle budding, and enables membrane transfer to the Golgi apparatus. VCP Protein, Human (sf9, GST) is the recombinant human-derived VCP protein, expressed by Sf9 insect cells , with N-GST labeled tag.

HY-P7818

	CPVL Protein, Human (HEK293, His) rHuProbable serine carboxypeptidase CPVL, His; Probable serine carboxypeptidase CPVL; Carboxypeptidase vitellogenic-like; Vitellogenic carboxypeptidase-like protein; VCP-like protein; CPVL	Human	HEK293
	CPVL protein, a serine carboxypeptidase, may be involved in the digestion of phagocytic granules in lysosomes and in the inflammatory protease cascade. CPVL protein, a potential biomarker, may promote glioma progression by inhibiting STAT1 phosphorylation. CPVL Protein, Human (HEK293, His) is the recombinant human-derived CPVL protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701436

	VCPIP1 Protein, Human (sf9) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (sf9) is the recombinant human-derived VCPIP1 protein, expressed by sf9 insect cells , with tag free.

HY-P701435

	VCPIP1 Protein, Human (sf9, His) VCPIP1; Deubiquitinating protein VCPIP1; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCP/p47 complex-interacting 135-kDa protein	Human	Sf9 insect cells
	The VCPIP1 protein is a multifunctional deubiquitinating enzyme that plays a crucial role in a variety of cellular processes. It is an integral component of DNA repair and postmitotic Golgi and endoplasmic reticulum reassembly, promoting VCP-mediated Golgi stacking and tER formation. VCPIP1 Protein, Human (sf9, His) is the recombinant human-derived VCPIP1 protein, expressed by sf9 insect cells , with C-8*His labeled tag.

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Host:	Mouse (2) Rabbit (3)
Reactivity:	Human (5) Rat (2) Mouse (4)
Application:	IHC-P (3) ICC/IF (4) IP (2) IHC-F (2) WB (5) FC (2) ELISA (2)
Isotype:	IgG (3) IgG1 (2)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82630

	VCP Antibody (YA2375) 15S Mg(2+) ATPase p97 subunit; ALS14; ATPase p97; CDC48; IBMPFD; p97; TER ATPase; TERA; VCP; Yeast Cdc48p homolog	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	VCP Antibody (YA2375) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VCP.

HY-P82630A

	VCP Antibody (YA2375)(PBS only) 15S Mg(2+) ATPase p97 subunit; ALS14; ATPase p97; CDC48; IBMPFD; p97; TER ATPase; TERA; VCP; Yeast Cdc48p homolog	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	VCP Antibody (YA2375) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to VCP.

HY-P84401

	VCP Antibody (YA4098) p97; TERA; CDC48; FTDALS6	WB, ICC/IF, FC, ELISA	Human, Mouse
	VCP Antibody (YA4098) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VCP.

HY-P84401A

	VCP Antibody (YA4098)(PBS only) p97; TERA; CDC48; FTDALS6	WB, ICC/IF, FC, ELISA	Human, Mouse
	VCP Antibody (YA4098) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to VCP.

HY-P86298

	CPVL Antibody (YA5990) CPVL; VLP; PSEC0124; UNQ197/PRO223; Probable serine carboxypeptidase CPVL ; Carboxypeptidase, vitellogenic-like; Vitellogenic carboxypeptidase-like protein; VCP-like protein; hVLP;	WB, IHC-P	Human
	CPVL Antibody (YA5990) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CPVL.

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VCP Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VCP Human Pre-designed siRNA Set A contains three designed siRNAs for VCP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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